Posted on 09/10/2021 10:31:40 AM PDT by Qiviut
Abstract
Importance: Research is needed to demonstrate the efficacy of nasal povidone-iodine (PVP-I) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Objective: To evaluate the in vitro efficacy of PVP-I nasal antiseptic for the inactivation of SARS-CoV-2 at clinically significant contact times of 15 and 30 seconds.
Interventions: The SARS-CoV-2, USA-WA1/2020 strain, virus stock was tested against nasal antiseptic solutions consisting of aqueous PVP-I as the sole active ingredient. Povidone-iodine was tested at diluted concentrations of 0.5%, 1.25%, and 2.5% and compared with controls. The test solutions and virus were incubated at mean (SD) room temperature of 22 (2) °C for time periods of 15 and 30 seconds.
Design and setting: This controlled in vitro laboratory research study used 3 different concentrations of study solution and ethanol, 70%, as a positive control on test media infected with SARS-CoV-2. Test media without virus were added to 2 tubes of the compounds to serve as toxicity and neutralization controls. Ethanol, 70%, was tested in parallel as a positive control and water only as a negative control.
Main outcomes and measures: The primary study outcome measurement was the log reduction value after 15 seconds and 30 seconds of given treatment. Surviving virus from each sample was quantified by standard end point dilution assay, and the log reduction value of each compound was compared with the negative (water) control.
Results: Povidone-iodine nasal antiseptics at concentrations (0.5%, 1.25%, and 2.5%) completely inactivated SARS-CoV-2 within 15 seconds of contact as measured by log reduction value of greater than 3 log10 of the 50% cell culture infectious dose of the virus. The ethanol, 70%, positive control did not completely inactivate SARS-CoV-2 after 15 seconds of contact. The nasal antiseptics tested performed better than the standard positive control routinely used for in vitro assessment of anti-SARS-CoV-2 agents at a contact time of 15 seconds. No cytotoxic effects on cells were observed after contact with each of the nasal antiseptics tested.
Conclusions and relevance: Povidone-iodine nasal antiseptic solutions at concentrations as low as 0.5% rapidly inactivate SARS-CoV-2 at contact times as short as 15 seconds. Intranasal use of PVP-I has demonstrated safety at concentrations of 1.25% and below and may play an adjunctive role in mitigating viral transmission beyond personal protective equipment.
I posted this technical article, but there is a less technical article at this link ....
Gargling With Iodine Beats COVID
https://drsircus.com/general/gargling-with-iodine-beats-covid/
Selected excerpts from link:
A small randomized controlled trial suggesting that gargling with povidone-iodine clears the virus from the nose and throat within four days. This result comes as no surprise because, for a century, doctors have known that iodine is effective, not only for bacterial and fungal infections but for viruses as well.
On day 4, 100% of those in the povidone-iodine group had cleared the virus.
On May 26, another study was released, providing the first direct evidence that povidone-iodine, a widely used antiseptic, is capable of killing SARS-CoV-2, the coronavirus that causes COVID-19. As little as 0.5% povidone-iodine completely inactivated the virus in 60 seconds, comparable to 70% alcohol. Greater concentrations were equally effective but provided no additional benefit.
This second was an in vitro study, testing the ability to inactivate the virus when infecting isolated cells from the kidneys of African green monkeys. Povidone-iodine is traditionally used topically. This study does not provide any basis to suggest it should be swallowed orally, which might cause diarrhea or worse in large amounts because Povidone-iodine is not for oral consumption, but Lugols and Nascent Iodine are.
This suggests that 0.5% povidone-iodine solutions (which can be made by diluting 10% solutions) can be used inside the nose with a sterile swab, nasal irrigation system, or nasal spray that they can be swished in the mouth for 60 seconds to kill the virus.
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I went shopping today ... got povidone-iodine & used it as a mouthwash/rinse & nasal swab after I got home.
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Have had the stuff here for ages,
What rate for mouthwash gargle,couldnt determine from the article.
Wondering about 3% peroxide too
I can imagine the faces of co-workers who happen to see the results of you blowing your nose.
Egads - we have a gusher!
Dr. McM said put a couple of drops in a glass ... that is what I did.
You’ll have to scrounge around to find more exact measurements.
Hydrogen peroxide also makes a mouthwash, but I don’t know if it’s as good at knocking out SARS-CoV-2. Dr. Mercola likes to use a nebulized (food grade) hydrogen peroxide. When he mentioned it to Dr. Zelenko in regards to COVID, Dr. Z didn’t respond in a way that would lead you to believe he’s a ‘fan’.
Here’s a link to an article - it appears Dr. Mercola uses it as a treatment & you can also use it as a preventive after an exposure:
https://agrdailynews.com/2021/02/15/dr-mercola-nebulized-peroxide-my-favorite-treatment-choice/
I have chronic severe sinusitis with enduring psuedomonas infection and have tried every conceivable antimicrobial up my nose to no avail.
Anosmic for 20 years and just recently are there others who understand what it is to lose 1.5 of your 5 senses.
You have to dilute it. A couple of drops in water results in NONE of what you described.
As was explained to you, by OP, this is a DILUTED solution.
Geez....did you even bother to read the article?
We have store bought and homemade nasal spray solutions, with these ingredients.
Have used the drops (DILUTED, of course), for years, for mouth wash/rinse, as well.
Trust me I use it 50/50 in my water pic.
My dentist said whatever your dong at home keep it up.
It’s easy to do the math to dilute, unless you went to Public School.
👍😀
😂 Yep.
Did you buy the 10% solution and dilute it or were you able to find something more in this recommended dose?
Guess I ll keep my old saline nasal bottles on the ready for both solutions
CVS bottle I have had here for years is 10%
From Dr. Thomas E. Levy’s website.
I use hydrogen peroxide in my waterpik a couple times a week alternating with a good tartar control antiseptic mouthwash.
I went to public school sucked at math still do so Einsten,what is the rate for the 10% solution us dummies have access too ?
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