Posted on 09/07/2021 9:15:21 PM PDT by ConservativeMind
Researchers have shown that damage to the lining of the gut plays an important role in the development of rheumatoid arthritis, paving the way for a new approach to treating the disease.
In the pre-clinical study, the research team propose that restoration of the gut-barrier could offer a new therapeutic approach to reducing the severity of Rheumatoid arthritis (RA).
Professor Claudia Mauri said: "We wanted to know what was happening in the gut and whether changes to the intestinal lining—which usually acts as a barrier to protect the body from bacteria—are a feature of the disease and contribute to its development."
Using pre-clinical mouse models and patient samples, the team found that blood markers of gut damage were raised compared to healthy people even at the earliest stages of arthritis, and that these markers of damage got higher the more the disease progressed; and, unexpectedly, there were distinct signs of inflammation, as might be seen in inflammatory bowel disease. The team also showed that the lining of the gut became 'leaky,' potentially allowing the passage of bacteria to cross the gut lining into the body, enhancing inflammation both in the gut and potentially in the joints.
"Our findings suggest that the intestinal lining is a therapeutic target. Importantly, we found that using existing drugs that restore the gut-barrier integrity i.e., prevent the gut from becoming leaky or inhibit inflammatory cells from moving to and from to the gut, could reduce the severity of arthritis in pre-clinical models," says Professor Mauri.
"Current treatments for rheumatoid arthritis don't appear to correct the problems in the gut and so may leave the patient susceptible to reactivation of disease from the continuing inflammation in that area. Going forward, we need to evaluate the therapeutic impact of treating the intestinal lining of rheumatoid arthritis patients…”
(Excerpt) Read more at medicalxpress.com ...
There is definitely some validity to this: I know because Vol II of my book is entirely about the gut. It’s a deep dive.
That stated, I had zero issues with health after restoring my gut following a <30 year parasite issue...until the virus.
Before much was known about the virus and its effects, I was experiencing gut upset for WEEKS after my symptoms abated.
I strongly suspected that the virus was responsible for the gut issues. Then came some odd joint issues in my hands, which I later pegged as RA. I’d read the accounts of those who got the jabs and said lingering effects of the virus were relieved, but I was dubious about getting the jab for reasons irrelevant here.
I’ve seriously considered a multi-pronged approach to work out a theory about my body still harboring some virus.
Joe Rogan’s rapid recovery buoys my confidence that I may be able to implement a simple/effective eradication regimen.
I believe the virus triggered this mild RA, but I fail to understand how it’s persistent after a year. I’m in perfect health save for this irritating RA in 5 fingers (it comes & goes) and the only thing I haven’t done is a thorough body cleanse combined with antivirals.
I’m rather opinionated on matters of the gut (for good reason) but not going into it beyond that stated.
A friend of mind use to swear by Acidolphlus tablets and Blue-Green Algae.
The release of zonulin in the small intestine is the lynchpin of most autoimmune disease. Zonulin opens the “tight junctions” between the cells lining the small intestine, causing leaky gut.
No more chili dogs.
My daily regimen at the lunch hour is 5 grams of glutamine and 10 mg melatonin. 10 minutes later, I add 500 mg flush niacin and 500 mg NAC. My resting heart rate has been steady 64/65 for the last 4 weeks. The morning "vitamins" include 1 gram vitamin C, 10000IU D3. Evening included 50 mg zinc and 500 mg quercetin. The standard stuff to keep the bug at bay.
I love my probiotics. I make my fermented pickled ‘stuff’ weekly. CDB is also a decent anti-inflammatory with minimal impact on the organs like NSAIDS.
Just don’t dare say the badorangman drug...
Long story short...her diet was strictly controlled and most of the drugs she was one became unnecessary. She left the hospital and resumed life with her family. She even enjoyed riding 4 wheelers again in the dirt. Some months passed and a trip to a fast food restaurant allowed a "slip". She ate some cheese. She was "loopy" inside of 20 minutes. Confirmation of the cheese/loopy association. She resumed her strict diet and hasn't had problems since.
People who abuse alcohol commonly experience significant changes in their intestinal function. These changes can potentially support the onset of leaky gut syndrome, or worsen its effects once it appears.
Also, watch your alcohol consumption.
One small problem with your “theory”: there is no virus. It is entirely a social-political construction by media.
Go search for Claus Kohnlein, MD, Virus Mania. Some of his stuff is in German.
Here is an interview link
The key is inducing the goblet cells that line the gut to produce mucous. Normally a bacteria , Akermancia Municinphilia, (sp) feeds on the mucous and stimulates the goblet cells to produce mucous. That bacteria may be missing in those with autoimmune diseases.
“One small problem with your “theory”: there is no virus. It is entirely a social-political construction by media.”
Preaching to the choir, my FRiend. There is, however, definitely a blood toxin at work: Spike protein.
I’ve been through similar travails. The cure is near miraculous, but I’m left with a tremor. We both cited the bloodstream as a delivery vehicle, but there is another. Surrounding the small intestine is actually lymph fluid. The digestive system is operated by the vagus nerve with tendrils through these lymph channels. The vagus nerve enters the brain at the fourth ventricle. The fourth ventricle is the only part of the brain not protected by the multi-faceted blood-brain barrier. Studies have shown that antigen attacks can render nerves porous, creating channels. These channels become highways for food antigens to flow through. It provides direct access to the lower brain.
The zonulin response is unique to humans, and is age related. It’s not uncommon to see healthy people develop reactions to food antigens. Humans develop the zonulin response as a “viral marketing” technique, evolution’s attempt to find people who can survive epidemics. That says that nature’s strongest method of infecting people is through the digestive system.
Agree. One or two beers a year. Even so, it often results in bad acid indigestion. Sam Adams Oktoberfest on tap at Applebee's is usually my allowance.
Thanks for posting. I’m gonna look in to this......
Probiotics are great, but they represent such a small portion of the good bacteria in the gut. I recently read of a stool transplant that cured three MS patients; restoring their ability to walk.
BTTT.
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