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Moths and tree bark: How the Novavax Covid vaccine works
Nebraksa Medicine ^ | 08/11/2021

Posted on 08/11/2021 3:08:21 PM PDT by SeekAndFind

Novavax has created a fourth COVID-19 vaccine using moth cells and tree bark. Instead of an mRNA vaccine (Pfizer, Moderna) or a viral vector vaccine (Johnson & Johnson), Novavax is a subunit protein vaccine.

Infectious diseases expert Diana Florescu, MD, led the phase 3 clinical trial of the Novavax vaccine at the University of Nebraska Medical Center (UNMC). "Diversity in vaccine production helps increase the number of patients vaccinated," says Dr. Florescu. "Some might not accept mRNA vaccines, while others may be allergic to certain ingredients."

For example, some are allergic to polyethylene glycol (PEG), an ingredient in the mRNA (Pfizer and Moderna) vaccines. There's no polyethylene glycol (PEG) in Novavax.

How does the Novavax vaccine work?

The Novavax COVID-19 vaccine contains a protein (made using moth cells) plus an adjuvant (made from tree bark). An adjuvant is an ingredient added to boost a person's immune response, creating higher levels of antibodies.

The Novavax vaccine uses a telltale piece of the coronavirus: the notorious spike protein. All alone, the spike protein is harmless and can't cause COVID-19. When your immune system encounters the lonely spike protein, it produces antibodies against it. This gives you protection against future COVID-19 infection.

"Unlike mRNA vaccines, the spike protein is already premade in the Novavax vaccine. It's a shortcut," explains Dr. Florescu. "All the synthesis happens outside the body and we just give the end product: the spike protein."

Like other COVID-19 vaccines, Novavax does not cause COVID-19 infection. It can't get you sick. This vaccine doesn't contain either live or inactivated virus.

How did they get the spike protein?

The Novavax method uses moth cells to make spike proteins:

  1. Researchers select the desired genes that create certain SARS-CoV-2 antigens (spike protein).
  2. Researchers put the genes into a baculovirus, an insect virus.
  3. The baculovirus infects moth cells and replicates inside them.
  4. These moth cells create lots of spike proteins.
  5. Researchers extract and purify the spike proteins.

"The Novavax vaccine has no genetic material, only proteins," says Dr. Florescu. "The vaccine technology is more traditional, and it's very similar to a protein-based influenza vaccine."

Influenza vaccines have also used this moth cell factory method.

What does the adjuvant (soapbark tree extract) do?

Adjuvants increase the immune response to a vaccine. In this vaccine, soapbark tree extract adjuvant makes achieving immunity possible with a smaller dose of the spike protein.

Matrix-M is the adjuvant used by Novavax. It is based on a saponin extracted from the soapbark tree (Quillaja saponaria). The soapbark extract encourages immune cells to activate, generating a more potent immune response.

Saponins are found naturally in various plant species like beans and green peas. They're used in agriculture, animal feeds, veterinary vaccines and human food. Saponins can boost immune responses to proteins. Using the Matrix-M adjuvant, a smaller dose of spike protein achieves the desired immune response.

See how well the Novavax vaccine performed in phase 3 clinical trials here.


TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid19; novavax; vaccine
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To: packagingguy

The Novavax uses the very same tech as the Rubella vaccine of MMR fame.

Every kid in America has had it.

It’s a conventional vaccine.


21 posted on 08/11/2021 3:58:36 PM PDT by Mariner (War criminal #18)
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To: SeekAndFind

Aborted fetuses; anyone know? And Tree bark - sounds like HydroXychloroquine in a syringe.


22 posted on 08/11/2021 3:58:44 PM PDT by Chauncey Gardiner
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To: All

Contact me in 3 years after emergency use authorization...by then we’ll be on the Omega or Zoolander Variant.


23 posted on 08/11/2021 4:01:07 PM PDT by DHerion
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To: Jewbacca; packagingguy

Warfarin, the most widely used oral coagulant in America is made of rat poison.

We know warfarin, by the brand names Coumadin® and Jantoven® and as its generic name, warfarin. Warfarin is part of a group of plant-based compounds called coumarins.


24 posted on 08/11/2021 4:02:26 PM PDT by SeekAndFind
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To: scouter
Does anyone know if it was developed or tested using cell lines from aborted human fetuses or embryos?

I have not seen Novavax associated with either in it's development. I have not heard it claimed that they were employed in testing.

25 posted on 08/11/2021 4:03:03 PM PDT by the_Watchman
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To: wgmalabama
This would be a more acceptable vaccine to me. If I needed a vaccine.

I agree. Everyone in my family is trying to wait it out until Novavax is available. At that time, if we have to get vaccinated or it appears to be the prudent course of action, then this would be our vaccine of choice.

Unfortunately, the FDA seems to be dragging its feet.

26 posted on 08/11/2021 4:06:32 PM PDT by the_Watchman
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To: Chauncey Gardiner

RE: Aborted fetuses

Source: https://www.christianitytoday.com/ct/2021/january-web-only/covid-19-vaccine-christian-ethical-questions-fetal-cells.html

[Key excerpt]

Two other vaccine candidates, Novavax and Sanofi Pasteur, are still in trials but will likely be used as well. They do not use the fetal cell lines in development. Both of these are “protein subunit” vaccines, which use a protein from the virus to trigger an immune response.


27 posted on 08/11/2021 4:09:52 PM PDT by SeekAndFind
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To: TomGuy

And eat clothing.


28 posted on 08/11/2021 4:10:29 PM PDT by kaktuskid
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To: SeekAndFind
"All alone, the spike protein is harmless

Stopped reading at the first outright lie.

29 posted on 08/11/2021 4:13:14 PM PDT by jpsb
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To: Mariner

I pretty much thought saponins were GRAS. That’s why I was surprised at what was on drugs.com. Sea foam is from saponins and doesn’t kill you.


30 posted on 08/11/2021 4:15:00 PM PDT by packagingguy (Kit)
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Dr Euell Gibbons, paging Dr Euell Gibbons ...


31 posted on 08/11/2021 4:15:48 PM PDT by Gene Eric (Don't be a statist!)
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To: datura

But does this vaccine deliver instructions to your RNA to produce spike proteins? That seems to be a major cock up with the other choices.


32 posted on 08/11/2021 4:18:14 PM PDT by silverleaf (In a time of universal deceit, telling the truth is a revolutionary act)
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To: Varsity Flight

I recall stories that mention Gates’ desire to hunt down the faith genetics.


33 posted on 08/11/2021 4:18:28 PM PDT by Gene Eric (Don't be a statist!)
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To: the_Watchman

Same here. Waiting for Novavax.


34 posted on 08/11/2021 4:26:03 PM PDT by Tuxedo (My Social Credit Score is Zero Point Zero)
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To: TomGuy

LOL!


35 posted on 08/11/2021 4:34:38 PM PDT by Not A Snowbird (I do not recognize Biden’s authority.)
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To: the_Watchman

Yeah. It’s almost like Novavax didn’t get the memo.


36 posted on 08/11/2021 4:45:19 PM PDT by wgmalabama (We will find out if the Vac or virus risk was the correct choice - can we put truth above narrative)
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To: SeekAndFind

It’s not MRNA. It didn’t use aborted fetal tissue in development, but does in testing.

If I was forced to get a vaccine I would get Novavax. However it looks like their application for USA approval is very much delayed or might not ever happen. They have too much vaccine already paid for in USA, but there is huge demand in other countries.


37 posted on 08/11/2021 5:18:17 PM PDT by Mount Athos
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To: Governor Dinwiddie
This should have lots of appeal to the Earthy Crunchies.

It's "natural". But then so are rattlesnake venom and curare.

38 posted on 08/11/2021 5:34:54 PM PDT by AZLiberty (Awaiting the return of the king -- and I don't mean Elvis.)
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To: silverleaf

Actually, if you watch the video link I posted, the pathologist giving the lecture states quite clearly that the spike protein is the toxin - without any virus present. He wonders why we are injecting a very toxic substance into our bodies.


39 posted on 08/11/2021 5:55:29 PM PDT by datura (The voice that brought you peace has nothing left to say.)
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To: SeekAndFind
"For example, some are allergic to polyethylene glycol (PEG), an ingredient in the mRNA (Pfizer and Moderna) vaccines. There's no polyethylene glycol (PEG) in Novavax. "

Just what is this dangerous inactive ingredient? Polyethylene Glycol, otherwise known as PEG, Macrogol, Carbowax and many other names when combined with other substances, is not a household word unless your house holds biochemists. It is classified as biologically inert by our FDA. It is the “Gold Standard” for use in many medications to increase the blood clearance time, or in other words, the time it remains in one’s system, thereby enhancing drug effect. It is also used in drug manufacturing as an excipient for long term stabilization, bulking, and other therapeutic enhancements. It is used as a coating to prevent bacterial adhesion on orthopedic screws and sutures. In addition to medical uses, PEG is also used in cosmetics, foods, industrial applications, and other health and beauty products such as soaps, shampoos, toothpastes. It is also used as an e-cigarette liquid. PEG is everywhere in our environment, which is what many have surmised has led to a high percentage of the US population developing anti-PEG antibodies. Scientific studies to quantify the seriousness of the problem estimate that approximately 72% of the US population has acquired anti PEG antibodies... More: https://childrenshealthdefense.org/news/a-dangerous-inactive-ingredient/

40 posted on 08/11/2021 6:16:24 PM PDT by daniel1212 ( Turn to the Lord Jesus as a damned+destitute sinner, trust Him to save + be baptized + follow Him!)
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