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Long-lasting immune abnormalities detected in recovered COVID-19 patients
https://newatlas.com ^ | August 09, 2021 | By Rich Haridy & University of Adelaide

Posted on 08/10/2021 12:06:49 PM PDT by Red Badger

After six months, researchers detected immune system dysfunction in most recovered COVID-19 patients, regardless of initial disease severityPISHEVroman/Depositphotos

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New Australian research is offering a thorough look at the lasting impact of COVID-19 on immune system activity. Tracking a wide variety of biomarkers the research found immune abnormalities persisting at least six months after patients recover from acute disease.

Eighteen months into this global pandemic researchers are increasingly investigating the long-lasting effects of a SARS-CoV-2 infection. Dubbed "long COVID", growing numbers of patients are reporting persistent symptoms lingering for months following the acute disease.

The Australian research is following 69 recovered COVID-19 patients, the majority of whom (47) only suffered from mild disease. Because of Australia’s unique position in the world, having temporarily eliminated the virus from certain regions, the ongoing project can track long-term immune responses to an infection without worrying about re-infection or vaccination status.

This new study, not yet peer-reviewed or published in a journal, outlines the effects of an infection on the peripheral immune system in the six months after initial recovery. Blood samples were taken from each subject at three points in the six-month study.

The researchers investigated levels of around 130 different immune cells, as well as tracking antibody responses and measuring the expression of thousands of different genes relating to immune functions. The findings strikingly show persistent inflammatory responses and immune dysregulation up to six months after recovery.

“The study found substantial dysregulation of immune cell numbers that was strongest at 12-weeks post infection but was still evident in most cases for up to six months and potentially even longer,” explains David Lynn, one of the lead investigators on the project.

A number of genes linked to inflammation were found to be upregulated six months after infection. This indicates these dysfunctional immune mechanisms could be part of the long COVID mystery, however, Lynn is clear further research is needed to verify this hypothesis.

“One could logically infer that this dysregulation is linked to the physical symptoms of long COVID, however, further research is needed to prove this,” adds Lynn.

The new research is part of a growing body of evidence implicating immune system abnormalities in the pathology of long COVID. A UK study published in April detected persistent immune alterations in hospitalized COVID-19 patients six months after discharge.

This Australian research, however, focused on a variety of COVID-19 cases, ranging from mild to severe. And one of the biggest surprises in the new findings was the lack of any correlation between acute disease severity and the degree of post-infection immune dysfunction.

“We’ve seen a very broad spectrum in the rate of recovery and we still don’t understand why some people are recovering so much quicker than others,” says Lynn. “The level of disease severity doesn’t translate directly to the level of immune dysregulation and we haven’t been able to find any patterns indicating that an individual’s age or sex is a differentiating factor governing differences in recovery.”

One limitation in the Australian research is there is no data tracking long COVID symptoms in the cohort, so these findings cannot be directly linked with long COVID cases. But the immune dysfunction/long COVID hypothesis is becoming increasingly plausible.

Danny Altmann, an immunologist from Imperial College London, is part of a larger ongoing UK project investigating long COVID. He says there is precedent for viral infections triggering long-term chronic health conditions, glandular fever being a perfect example. And those chronic conditions can be linked to lingering immune dysfunction following an acute infection.

“I describe it as a bit like somebody throwing a hand grenade into our immune system, that all the populations [of immune cells] are completely topsy turvy and unsettled for years,” Altmann explained in a recent interview. “And, that's a guess, but we've got the technology to look at that in quite a lot of detail.”

Branka Grubor-Bauk, an Australian researcher working on the new study, suggests there is an urgent need for a better understanding of long COVID, particularly as it looks like the virus is not going away.

“At present there are no treatments for long COVID sufferers and as the world slowly transitions to living with COVID, we will need to find answers and better solutions to prevent and treat long COVID in the years to come” says Grubor-Bauk.

The new research is yet to be peer-reviewed or published but it has been posted on medRxiv.

Source: University of Adelaide


TOPICS: Business/Economy; Education; Health/Medicine; Society
KEYWORDS: abnormalimmune; covid; immunesystem; longcovid; sideeffects; vaers
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1 posted on 08/10/2021 12:06:49 PM PDT by Red Badger
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To: Red Badger

So, now they’re saying you can’t catch COVID *at all*, even if no symptoms and you end up with antibodies for it? If so, f*ck this world.


2 posted on 08/10/2021 12:10:23 PM PDT by CatOwner (Don't expect anyone, even conservatives, to have your back when the SHTF in 2021)
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To: ransomnote

PING!.................


3 posted on 08/10/2021 12:12:32 PM PDT by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

The Chicoms engineered this thing quite well.


4 posted on 08/10/2021 12:12:49 PM PDT by gitmo (If your theology doesn't become your biography, what good is it?)
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To: Red Badger

What could possibly go wrong?


5 posted on 08/10/2021 12:14:30 PM PDT by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: Red Badger

There is no mention in the FR article whether these covid infected people were vaccinated or not. Or whether it is their first or second infection. -Tom


6 posted on 08/10/2021 12:17:27 PM PDT by Capt. Tom (.It's COVID 2021 - The Events, not us, are still in charge -Tom)
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To: Red Badger

Junk science.

Notice how they determined an a priori conclusion and seek corroborating data.

That’s not science.

I’m sure their assays and tests were fine all three of them - lol) but this experimental design tells very little.

But they claim broad detailed conclusions.


7 posted on 08/10/2021 12:18:18 PM PDT by ifinnegan ( Democrats kill babies and harvest their organs to sell)
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To: Red Badger

FLCCC has a protocol for treating “long haul Covid” .... some people’s symptoms have resolved almost immediately or in a matter of days. It is also a treatment for post-vaccine inflammatory syndrome (if you know anyone having issues post-vax).

https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/

“Given the lack of available treatment recommendations in the setting of large numbers of patients suffering with this disorder globally, the FLCCC developed the I-RECOVER protocol in collaboration with a number of expert clinicians including Dr. Mobeen Syed, Dr. Ram Yogendra, Dr. Bruce Patterson, and Dr. Tina Peers. Although our varied yet often overlapping treatment approaches were initially empiric, while based on both preliminary investigations into and prevailing theoretical pathophysiologic mechanisms of LHCS, the consistently positive clinical responses observed, often profound and sustained, led the collaboration to form the consensus protocol below. As with all FLCCC protocols, we must emphasize that multiple aspects of the protocol may change as scientific data and clinical experience in this condition evolve, thus it is important to check back frequently or join the FLCCC Alliance to receive notification of any protocol changes.”


8 posted on 08/10/2021 12:20:04 PM PDT by Qiviut (Faith is the antidote to fear. Mindset: be a victor, not a victim.)
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To: Red Badger
1) World population is aging

2) Old people buy less crap

3) Greed

4) Get old people to spend more money on health care

Problem solved!

9 posted on 08/10/2021 12:30:51 PM PDT by who_would_fardels_bear (This is not a tagline.)
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To: who_would_fardels_bear

1) Kill old people

2) Things become cheaper for young people...................


10 posted on 08/10/2021 12:32:08 PM PDT by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger
Never going away. We'll have a whole new Department of Covid in our government.
11 posted on 08/10/2021 12:32:40 PM PDT by TornadoAlley3 ( I'm Proud To Be An Okie From Muskogee)
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To: gitmo

Yep. And they’re getting away with it.


12 posted on 08/10/2021 12:36:34 PM PDT by Eagles6 (Welcome to the Matrix circa 1984.)
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To: Red Badger

69 Aussies who had covid and recovered.

Were they hospitalized?

Are they checking their vitamin D serum levels?

Are these obese Aussies?

Do these Aussies have comorbidities?


13 posted on 08/10/2021 12:51:54 PM PDT by aMorePerfectUnion (“Fraud vitiates everything.” )
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To: Red Badger

I think it’s likely ‘long covid’ is graphene oxide based. No, I don’t believe their propaganda campaign. Their fake vaccine and fake PCR tests have so thoroughly distorted data that they can’t expect me to trust them.


14 posted on 08/10/2021 12:53:44 PM PDT by ransomnote (IN GOD WE TRUST)
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To: Red Badger

I had no sense of taste or smell for over two months after having COVID. I still do not think it is completely back a year later.


15 posted on 08/10/2021 12:53:47 PM PDT by Hildy (In an unforgiving world, only the shameless survive.)
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To: gitmo

The long game has yet to be revealed


16 posted on 08/10/2021 1:12:36 PM PDT by z3n
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To: gitmo

It makes me think the real purpose of COVID was to damage immune systems before the release of the next wave.


17 posted on 08/10/2021 1:17:31 PM PDT by PapaBear3625
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To: Red Badger

“This new study, not yet peer-reviewed or published in a journal...”

Key to article.


18 posted on 08/10/2021 1:21:39 PM PDT by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit..)
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To: PapaBear3625

Could be. But how do they keep from wiping themselves out? Do they have a secret vaccine?


19 posted on 08/10/2021 1:24:02 PM PDT by gitmo (If your theology doesn't become your biography, what good is it?)
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To: z3n
The long game has yet to be revealed

If the long game, heck, short game, is for God to reboot the planet, he has my vote. The amount of misery being foisted by the ChiComs and the leftists is not going to be countered enough to stop them. Watching patriots rot in DC cells for expressing their opinions peacefully is just too painful to continue. Buy hey, with most keyboard warriors, as long as it isn't happening to them directly, they're good. SMFH

20 posted on 08/10/2021 1:25:17 PM PDT by CatOwner (Don't expect anyone, even conservatives, to have your back when the SHTF in 2021)
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