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To: LittleLinda
"we don’t know about the long-term side effects"

The two I'm aware of
1. blood clots will be for years for older people. Young will be decades as their heart cell tissues doesn't replace themselves as fast as older people.

2. all forms of cancer. Something i wasn't aware of. Spike viral proteins cause cancer (IE: colds, flu, covid, vax.) The longer your body fights the viruses the more likely you will get cancer.
Coronaviruses (CoVs) belong to coronaviridae family and are the largest RNA viruses identified till date S2 subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study
https://archive.is/DAY6i#selection-4493.44-4493.47
2,037 posted on 08/03/2021 12:13:19 AM PDT by Steve Van Doorn (*in my best Eric Cartman voice* 'I love you, guys')
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To: Steve Van Doorn
VERY interesting Steve, thanks for posting the link.

I guess this helps explain the patients whose cancer was in remission starting up again?

Copying some of the data here in case twatter swatters the tweet.

Walter M Chesnut@Parsifaler FollowFollow @Parsifaler

THIS IS MY MOST IMPORTANT DISCOVERY TO DATE

1) THE SPIKE PROTEIN AS METATASTIC CANCER

The Spike Protein of SARS-CoV-2 has been shown to interact with tumor suppressor p53. p53 mutations are the most common genetic alterations found in cancers and are observed in >50% of all tumors.

From the approximately 200 different single mutations already described in p53, several residues are considered as hotspots, including R248, R175, G245, R273, R249, and R282 (Petitjean et al. 2007). All of these residues are found in p53's core domain, which is responsible for its interactions with DNA.

For this reason, most of these mutants are incapable of exerting the wild-type (WT) level of transcriptional activity (Bullock et al. 1997).

The most frequent effect of p53 mutations is loss-of-function (LoF); however, GoF effects,such as increased migration, invasion, and metastasis, have also been observed. Mutations in the p53 gene occur in more than half of human cancers and often result in altered transcriptional activities.

METATASTIC CANCER AND PRION DISEASE

Recently discovered characteristics of the tumor suppressor p53 include its prion-like properties and cellular uptake mechanisms, which are related to its GoF and are associated with tumor formation and malignancy.

The implications are nothing short of cataclysmic.

S2 Subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324311/

Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046694/

So to sum it up quickly, it stops our bodies tumor suppressors that routinely stop cancer cells from developing?

Walter M Chesnut @Parsifaler

Among other nasty cancer activities, yes.

endoc @endocdoc

Replying to @Parsifaler

For me, the greatest discovery is the awakening of the HERV's by the virus or its spike.


2,041 posted on 08/03/2021 2:32:45 AM PDT by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: Steve Van Doorn
Coronaviruses (CoVs) belong to coronaviridae family and are the largest RNA viruses identified till date S2 subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study

https://archive.is/DAY6i#selection-4493.44-4493.47

Don't trust in silico as accurate. Too many cofounding variables.

Use it at most as a guide to where to look.

2,052 posted on 08/03/2021 4:52:37 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: Steve Van Doorn

Steve Van Doorn wrote:


“we don’t know about the long-term side effects”

The two I’m aware of
1. blood clots will be for years for older people. Young will be decades as their heart cell tissues doesn’t replace themselves as fast as older people.

2. all forms of cancer. Something i wasn’t aware of. Spike viral proteins cause cancer (IE: colds, flu, covid, vax.) The longer your body fights the viruses the more likely you will get cancer.
Coronaviruses (CoVs) belong to coronaviridae family and are the largest RNA viruses identified till date S2 subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study
https://archive.is/DAY6i#selection-4493.44-4493.47

Unrolled thread:

https://threadreaderapp.com/thread/1390105260132339722.html

Can’t find where he talks about the BRCA though.


2,670 posted on 08/04/2021 4:08:45 PM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000))
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