Early COVID-19 Therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in Outpatient Settings Significantly Improved COVID-19 outcomes compared to Known outcomes in untreated patients

Science Direct ^ | 07/08/2021 | Flavio A.Cadegiani, AndyGoren, Carlos G.Wambier, JohnMcCoy

[SeekAndFind]

New Microbes and New Infections

Available online 7 July 2021, 100915

In Press, Journal Pre-proof

Highlights

•

Subjects with early COVID-19 treated with azithromycin combined with nitazoxanide, ivermectin or hydroxychloroquine showed overwhelming improvements compared to sex-, age-, disease-, and comorbidities-matched untreated patients.

•

Improvements with early treatments include reduction of up to 36.5% in viral shedding (p < 0.0001), 85% in disease duration (p < 0.0001), 95% in post-COVID symptoms, and 100% in respiratory complications, hospitalization, mechanical ventilations, deaths (p < 0.0001 for all). For every 1,000 confirmed cases for COVID-19, at least 140 hospitalizations, 50 mechanical ventilations and five deaths were prevented with treatment.

•

Because of the unquestionable benefits of the combination between early COVID-19 detection and early pharmacological approaches and the well-established safety profile of the drugs employed in the treatment regimens for COVID-19, it has become ethically questionable to conduct further studies employing full placebo arms in early COVID-19.

Abstract

In a prospective observational study (pre-AndroCoV Trial), the use of nitazoxanide, ivermectin and hydroxychloroquine demonstrated unexpected improvements in COVID-19 outcomes, when compared to untreated patients. The apparent yet likely positive results raised ethical concerns on the employment of further full placebo84 controlled studies in early stage COVID-19.

The present analysis aimed to elucidate whether full placebo-control randomized clinical trials (RCTs) on early-stage COVID-19 are still ethically acceptable, through a comparative analysis with two control87 groups. Active group (AG) consisted of patients enrolled in the Pre AndroCoV-Trial (n = 585). Control Group 1 (CG1) consisted of a retrospectively obtained group of untreated patients of the same population (n = 137), and Control Group 2 (CG2) resulted from a precise prediction of clinical outcomes based on a thorough and structured review of indexed articles and official statements.

Patients were matched for sex, age, comorbidities and disease severity at baseline. Compared to CG1 and CG2 AG showed reduction of 31.5-36.5% in viral shedding (p < 0.0001), 70-85% in disease duration (p < 0.0001), and 100% in respiratory complications, hospitalization, mechanical ventilations, and deaths (p < 0.0001 for all). For every 1,000 confirmed cases for COVID-19, at least 70 hospitalizations, 50 mechanical ventilations and five deaths were prevented.

Benefits from the combination of early COVID-19 detection and early pharmacological approaches were consistent and overwhelming when compared to untreated groups, which, together with and well-established safety profile of the drug combinations tested in the Pre-AndroCoV Trial, precluded our study to continue employing full placebo in early COVID-19.

Keywords

COVID-19

SARS-CoV-2

hydroxychloroquine

ivermectin

nitazoxanide

antiandrogen

dutasteride

spironolactone

proxalutamide

---

DOWNLOAD FULL TEXT IN PDF FORMAT

[SeekAndFind]

Ping for your interest.

[SeekAndFind]

AUTHOR CONTACTS:

1. Flavio A. Cadegiani
Corpometria Institute, Brasília, DF, Brazil
Applied Biology, Inc. Irvine, CA, USA
Corresponding author. Flavio A. Cadegiani, MD, MSc, PhD Corpometria Institute, Brasilia, Brazil SGAS 915 Sala 260/262/264, Brasilia, DF, Brazil, 70-390150 Tel.: +55 61 996506111; fax: +55 61 33464733.

2. Andy Goren

Applied Biology, Inc. Irvine, CA, USA

3. Carlos G. Wambier
Department of Dermatology, The Alpert Medical School of Brown University, RI, USA

4. John McCoy
Applied Biology, Inc. Irvine, CA, USA

[saintgermaine]

Early COVID-19 Therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in Outpatient Settings Significantly Improved COVID-19 outcomes compared to Known outcomes in untreated patients

And greatly reduced chance to end up with some adverse reaction, either shortly after getting a shot or sometimes down the road.

[packagingguy]

Ivermectin is good for ridding your bunnies of parasites. Not kidding. So if you catch the WuFlu take your bunny medicine.

[Texas Fossil]

Thank you for posting.

The experts at the top of this mess are guilty of malpractice on a global scale. They new better, but ignored success by doctors treating the patients with the tools that were approved by the FDA for a number of illnesses. This is public deception and betrayal on a level that the world has never seen before.

It is about the Globalist Agenda, not about public health.

[ransomnote]

(h/t Cathi)

Ivermectin for the treatment of COVID-19 disease: Too good to pass up or too good to be true? 

Mark J Siedner, MD MPH

Open Forum Infectious Diseases, ofab318, https://doi.org/10.1093/ofid/ofab318

Published:

 

14 June 2021

• PDF
  
  "The results are compelling. They identify a clinically significant benefit in pooled estimates for most
  of their selected outcomes. For example, they estimate a mean reduction in time to viral clearance
  of 3 days (95%CI 1-5), a reduction in time to clinical recovery of 1.5 days (95%CI 0.4-2.8), a reduction
  in duration of hospitalization of 4.3 days (95%CI 0.0-8.6) and 56% reduced risk of mortality (95%CI 23-75%). Notably, their estimates remain largely similar after excluding studies at high risk of bias.

  
  And, although the included studies do not overlap, their results are largely consistent with many 17–19
  (but not all 20) other meta-analytic evaluations of ivermectin conduct by other groups. Even the most
  ardent skeptic should be given pause by this data.

  
  Downloaded from https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab318/6298585 by guest on 07 July 2021
  Accepted Manuscript

[musicman]

BTTT!!!

[semimojo]

Department of Dermatology, The Alpert Medical School of Brown University, RI, USA

????

[musicman]

Help FR Continue the Conservative Fight!
Your Monthly and Quarterly Donations
Help To Keep FR In The Battle !!

Sponsoring FReepers are contributing
$10 Each time a New Monthly Donor signs up!
Get more bang for your FR buck!
Click Here To Sign Up Now!

[Bshaw]

“This is public deception and betrayal on a level that the world has never seen before. It is about the Globalist Agenda, not about public health.”

I concur, the swath of the planet that did not have a Covid pandemic, (See countries with Malaria and widespread HCQ use), this is the tell.

Fauci and his conga-line of fools in the government and media knew damned well of their treachery.

I just witnessed the Jim Jones-ing of an American election year in 2020; orchestrated by DC elites and China.

There WAS a candidate that received 80,000,000+ votes in the 2020 election, but he’s not the one sitting in the Oval office.

Trump won and we ALL know it.

True justice for what just transpired, and for what should be done with those involved, would be nothing less than macabre — zero mercy or grace.

My original tag line has been in effect since my first day as a FReeper!

[Texas Fossil]

On November 3-4, 2020 and act of war was committed against this nation and there were many high US public officials who aided and abetted those nations who plotted what I refer to as Pearl Harbor II.

[ProtectOurFreedom]

Interesting...yet another anti-parasite medicine to complement the anti-parasitic Ivermectin!

---

FDA licensed nitazoxanide (Alinia®, Romark Laboratories, Tampa, FL, USA) for treatment of cryptosporidiosis in children aged 1-11 years in November 2002. In June 2004, nitazoxanide was also licensed for older children and adults. It can now be prescribed for all patients ≥ 1 year of age. Clinical cure (resolution of diarrhea) rates range from 72-88%. Parasitologic cure (no Cryptosporidium detected in stool) rates range from 60-75%. Parasitologic cure rate was a key consideration in developing prevention recommendations that ask people to refrain from swimming for 2 weeks after resolution of symptoms. Retesting of treated persons is not considered necessary.

Nitazoxanide appears to be well tolerated and different treatment regimens have been used for a variety of infections. Immunocompetent persons with cryptosporidiosis have been treated with multiple 3-day courses of nitazoxanide. Seven-day courses have also been used in early studies for cryptosporidiosis and other parasitic infections. Nitazoxanide has been approved for treatment of diarrhea caused by Cryptosporidium in people with healthy immune systems. It is presently not approved to treat immunodeficient persons because nitazoxanide oral suspension and nitazoxanide tablets have not been shown to be superior to placebo for the treatment of diarrhea caused by Cryptosporidium in HIV-infected or immunodeficient patients.

Cryptosporidium now causes over half of the reported waterborne disease outbreaks associated with swimming in chlorinated public swimming pools

[grey_whiskers]

Thanks, SeekAndFind

*PING*

[grey_whiskers]

He’s a doctor at a Medical School at an Ivy League University.

[thinden]

Bttt

[wastedyears]

Trump was saying this over a year ago.

[wastedyears]

Malpractice? No, this is crimes against humanity. This is the kind of stuff you prosecute at the Hague.

[jimwatx]

I can vouch for nitazoxanide, I had that on hand before my ivermectin order came through and when my sister was confirmed to have covid-19 I sent her some. She’s a nurse with several co-morbidities like asthma, missing spleen, multiple sclerosis, ect. She took just one 500 mg tablet a day and the only symptoms she experienced was slight aches and pain along with fatigue for a few days.

[Texas Fossil]

Yes, on many levels.

And it still continues. A year or two will make this hard to cover up. Hence they are going on to the next threat, the mutations. To distract from their crimes.

But the real agenda is much bigger than just this. Great Evil is behind this and it is powered with money from a corrupted international banking system.