Killing off old cells might mean relief from persistent jaw pain (cells made young w/Quercetin)

Medical XPress / University of Connecticut / Aging Cell ^ | July 7, 2021 | Yeuying Zhou, et al.

[ConservativeMind]

Pain where the jaw hinges to the skull is both common and difficult to treat. Killing off aged cells might be the secret to healing it.

Age worsens joint deterioration in many parts of the body. Scientists aren't sure why, but in many cases this deterioration seems related to old, damaged cells that refuse to die. Normally, cells in our body are constantly renewing themselves. Most cells that get damaged or begin to turn cancerous are removed by our immune system to make way for fresh, young, healthy cells.

But sometimes these cells stick around. Called senescent cells, they are somehow resistant to the normal ways the body rids itself of damaged cells.

And senescent cells don't just accumulate. They seem to actively promote inflammation and damage to surrounding cells.

They combined Dasatinib, a senolytic that removes senescent cells from connective tissue like cartilage and bones, and Quercetin, which goes after senescent cells in blood vessels and skin. The combination is necessary because joints are complex structures made of many different types of tissue.

The researchers gave 24-month-old mice (equivalent to 70 to 80-year-old humans) a combination of Dasatinib and Quercetin three times every two weeks for six weeks. After the treatments, the cells in the jaw joints of the old mice looked more like the cells in the jaw joints of 4-month-old mice (equivalent to 15 to 20-year-old humans) than those of their fellow oldsters. The cartilage was thicker and the bone smoother, making the joints look like those of much younger animals. No other treatment known at this time can thicken cartilage in joints.

Another study recently published by Xu's team in NPJ Regenerative Medicine shows that treating aged stem cells in a petri dish with the Dasatinib-Quercetin combination rejuvenated them.

[bgill]

Ah, to look and feel 18 again.

[ckilmer]

What are doses.

I’ve seen lately that its best to do high dose querticin 1-3 times a month. But the doses remain fuzzy

[yefragetuwrabrumuy]

“Addicted” might not be enough. A typical 1-2 times daily dose equals about 40lbs of strawberries.

[blueyon]

thank you

[GOPJ]

Senolytics are available over-the-counter. One, fisetin, is a component of strawberries.

Fisetin (3,3',4',7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, ...

Interesting...

[ConservativeMind]

Quercetin quickly gets to a problematic level much above 800 mg, in my understanding.

Sublingual or liposomal versions would likely be a better long-term approach. As another mentioned on this thread, Alive by Science seems to specialize in those forms.

Do note quercetin can conflict with other supplements, from my reading.

I have never taken quercetin daily. My wife has, from time to time, though.

Curcumin has similar problematic issues at higher levels. The best curcumin, according to ConsumerLab, is the ultra pure extract called “C3 Complex,” which we get in the Doctor's Best “High Absorption Curcumin from Turmeric Root with Bioperine.” I now take daily half of a 1000 mg pill, simply due to concerns with not wanting to overtax my liver, but damage was found to occur with other forms over long periods of time.

[ckilmer]

yes. my understanding is that quercetin is most effective at high doses but that this should only be done nor more than 2-3 times a month.

I take 1500 mg of fisetin at a setting once a month
2 grams fo quercetin once a month.

We looked at the data for fisetin last year. 1500 matches the doses in the experiments.

But I have seen no such similar data for quercetin