Posted on 06/07/2021 10:45:41 AM PDT by Red Badger
Consuming large amounts of daily caffeine may increase the risk of glaucoma more than three-fold for those with a genetic predisposition to higher eye pressure according to an international, multi-center study. The research led by the Icahn School of Medicine at Mount Sinai is the first to demonstrate a dietary — genetic interaction in glaucoma. The study results published in the June print issue of Ophthalmology may suggest patients with a strong family history of glaucoma should cut down on caffeine intake.
The study is important because glaucoma is the leading cause of blindness in the United States. It looks at the impact of caffeine intake on glaucoma, and intraocular pressure (IOP) which is pressure inside the eye. Elevated IOP is an integral risk factor for glaucoma, although other factors do contribute to this condition. With glaucoma, patients typically experience few or no symptoms until the disease progresses and they have vision loss.
“We previously published work suggesting that high caffeine intake increased the risk of the high-tension open angle glaucoma among people with a family history of disease. In this study we show that an adverse relation between high caffeine intake and glaucoma was evident only among those with the highest genetic risk score for elevated eye pressure,” says lead/corresponding author Louis R. Pasquale, MD, FARVO, Deputy Chair for Ophthalmology Research for the Mount Sinai Health System.
The scientists have demonstrated that consuming caffeine (about 3 mg/kg or the equivalent of a strong coffee) half an hour before aerobic exercise significantly increases fat-burning.
A team of researchers used the UK Biobank, a large-scale population-based biomedical database supported by various health and governmental agencies. They analyzed records of more than 120,000 participants between 2006 and 2010. Participants were between 39 and 73 years old and provided their health records along with DNA samples, collected to generate data. They answered repeated dietary questionnaires focusing on how many caffeinated beverages they drink daily, how much caffeine-containing food they eat, the specific types, and portion size. They also answered questions about their vision, including specifics on if they have glaucoma or a family history of glaucoma. Three years into the study later they had their IOP checked and eye measurements.
Researchers first looked at the relationship looked between caffeine intake, IOP and self-reported glaucoma by running multivariable analyses. Then they assessed if accounting for genetic data modified these relationships. They assigned each subject an IOP genetic risk score and performed interaction analyses.
The investigators found high caffeine intake was not associated with increased risk for higher IOP or glaucoma overall; however, among participants with the strongest genetic predisposition to elevated IOP — in the top 25 percentile — greater caffeine consumption was associated with higher IOP and higher glaucoma prevalence. More specifically, those who consumed the highest amount of daily caffeine- more than 480 milligrams which is roughly four cups of coffee — had a 0.35 mmHg higher IOP. Additionally, those in the highest genetic risk score category who consumed more than 321 milligrams of daily caffeine — roughly three cups of coffee — had a 3.9-fold higher glaucoma prevalence when compared to those who drink no or minimal caffeine and in lowest genetic risk score group.
“Glaucoma patients often ask if they can help to protect their sight through lifestyle changes, however this has been a relatively understudied area until now. This study suggested that those with the highest genetic risk for glaucoma may benefit from moderating their caffeine intake. It should be noted that the link between caffeine and glaucoma risk was only seen with a large amount of caffeine and in those with the highest genetic risk,” says co-author Anthony Khawaja, MD, PhD, Associate Professor of Ophthalmology University College London (UCL) Institute of Ophthalmology and ophthalmic surgeon at Moorfields Eye Hospital. “The UK Biobank study is helping us to learn more than ever before about how our genes affect our glaucoma risk and the role that our behaviors and environment could play. We look forward to continuing to expand our knowledge in this area.”
Reference: “Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption — A Gene–Diet Interaction Study from the UK Biobank” by Jihye Kim, PhD; Hugues Aschard, PhD; Jae H. Kang, ScD; Marleen A.H. Lentjes, PhD; Ron Do, PhD; Janey L. Wiggs, MD, PhD; Anthony P. Khawaja, PhD, FRCOphth and Louis R. Pasquale, MD on behalf of the Modifiable Risk Factors for Glaucoma Collaboration, 14 December 2020, Ophthalmology. DOI: 10.1016/j.ophtha.2020.12.009
National Eye Institute which is part of the National Institutes of Health, and New York Eye and Ear Infirmary of Mount Sinai helped to fund this study.
LOL. If it’s caffeineated, I’ll swill it. Unless it’s a Coke product.
I need my brain lube.
If folks are concerned, they should talk to their eye doc/doc doc though I have yet to meet one that won’t tell you to cut back on the caff.
FWIW, my pressures are awesome. I see my eye folks frequently, so I know.
Why don’t they just say “glaucoma” instead of “blinding eye disease”?
Of course, it won’t generate as many clicks that way.
ROFL!! Thanks for the laugh!!
Them: coffee will make you blind
Me: then I’ll drink in the dark
I was drinking 2-3, 20 oz dirt Feed per day and noticed my eye sight was blurry. Stopped cold turkey and 6 months later the blurriness cleared up.
Dirt Feed = diet Dew
I have a similar problem with beer.
Covid has been found on coffee
You sure slipped that right on in there. LOL!
It just goes to show you, it’s always something.
The smoker you get the player you drink?....................
I’ve been drinking coffee since 1st grade, when there wasn’t decalf. I just get a little nervous and jerky sometimes but that’s about it.
I do 6 to 8 cups of the strong stuff every day. Doomed and I am only 82.
Too much and you’ll go blind!
But I also use Xalatan(tm) Latanoprost .005% solution every day for the last 20 years. Maintains eye pressures in the 13-15 range. (<20 is good, 20+ is of concern, 25+ indicates need for immediate therapeutic action - which is often daily eyedrops, sometimes laser surgical procedure to open up drainage ports in eye.)
So, I can continue to swill caffeinated soda.
Every person in history who has ingested coffee has died!
My wife never drinks coffee; she is being treated for eye pressure. I drink coffee all day and have really good eye pressure.
Not a valid study unless they go back to pre puberty years to see if it’s not really soap poisoning.
After the Battle of Vienna in the 17th century (yet another attempt by Muslim armies to conquer the heart of Europe), the Christian victors went into the battlefield to gather weapons and supplies from the vacated Muslim base. That also meant interrogating the wounded Muslims who couldn't escape.
They learned the secret to why the Muslims seemed to fight longer without getting tired. It was from a drink made from kafir beans. The Muslims called them that because the Ethiopians wouldn't cave to the persistent demands of the attacking Muslims to convert or die. So the Muslims referred to the Christian Ethiopians as infidels -- kafir. And thus the beans they imported from Ethiopia were kafir beans -- they reason we English speakers call them coffee beans.
So every time you time you drink it you should be heartened with an I-ain't-convertin'-from-Christ-no-matter-what kind of attitude.
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