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Non-caloric sweetener reduces signs of fatty liver disease in preclinical research study (Rebaudioside A from Stevia)
MedicalXPress/Children's Hospital Los Angeles ^ | May 05, 2020

Posted on 06/05/2021 6:48:30 PM PDT by ConservativeMind

There is clear evidence that high sugar consumption leads to obesity and fatty liver disease. Synthetic and natural alternatives to sugar are available, but little is known about the effects of these non-caloric sweeteners on the liver. A new study led by Rohit Kohli, MBBS, MS, shows that stevia extract can reduce markers of fatty liver disease.

The Centers for Disease Control and Prevention reports that obesity affects nearly 19% of children. An associated condition called non-alcoholic fatty liver disease affects one out of every 10 children. Fatty liver disease can lead to cirrhosis and liver cancer. Consumption of too much sugar can lead to both obesity and fatty liver disease.

"Sugary foods and drinks can cause scarring in the liver," says Dr. Kohli, "but we don't know how non-caloric sweeteners may affect liver disease." In a first-of-its-kind study, Dr. Kohli addressed and answered the question: Can non-caloric sweeteners improve signs of fatty liver disease?

Using a preclinical model, he tested two non-caloric sweeteners, sucralose and stevia extract. Both are widely available and appear in many sweetened foods and drinks. "We were interested in those two compounds because they are the newest and least studied in the context of liver disease and obesity," says Dr. Kohli.

The results were striking. "We compared these sweeteners head to head with sugar," he says. "Stevia extract lowers glucose levels and improves markers of fatty liver disease." These markers include fibrosis and fat levels in the liver. The study also uncovered some potential mechanisms that could be responsible for reversing these markers of fatty liver disease. "We saw a decrease in signs of cellular stress and some changes in the gut microbiome," says Dr. Kohli

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: fattyliverdisease; obesity; reba; rebaudiosidea; stevia; sugar; sweetener
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To: texas_mrs

I prefer erythritol or allulose, but Reb A or the generic form is the only way I can enjoy stevia.


21 posted on 06/05/2021 8:48:24 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: anonsquared

The “studies” were not the most legit:

https://www.conceiveeasy.com/get-pregnant/does-stevia-cause-infertility/


22 posted on 06/05/2021 8:50:51 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: CondoleezzaProtege

“Stevia gives me migraines”

every form of stevia, including the supposedly highly purified versions, give both myself and mrs. catnipman instant, vicious headaches, and neither one of us is predisposed to headaches in general ...


23 posted on 06/05/2021 8:52:52 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: Don W

“If you have a pet do NOT let it eat anything with erithritol. It is lethal to some animals.”

pretty much true with manitol, sorbitol and all the other sugar alcohols ... sorbitol in particular is REALLY bad news for kitties: totally lethal in tiny quantities ...


24 posted on 06/05/2021 8:56:26 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: The MAGA-Deplorian

Agreed- it leaves a nasty aftertaste- all of the artificial do that I’ve tried- i tried to get used to them- but nope- no way-


25 posted on 06/05/2021 9:10:23 PM PDT by Bob434
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To: The MAGA-Deplorian

At first there is a hint of vanilla flavor, then after a few days I didn’t notice it any longer. I kind of liked that. So no, no aftertaste.


26 posted on 06/05/2021 9:27:46 PM PDT by Karl Spooner
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To: Don W

Thank you for the warning.


27 posted on 06/05/2021 11:01:10 PM PDT by Williams (Stop Tolerating The Intolerant)
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To: catnipman

Interesting. So I’m not alone.

I understand there is an excess sugar intake in our country but at the end of the day...i feel natural sugar is the least of all evils as far as sweeteners go. Maybe go for raw and unrefined?

Honey is ok for certain things.

Agave I’m on the fence.


28 posted on 06/05/2021 11:12:44 PM PDT by CondoleezzaProtege
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To: The MAGA-Deplorian

I just was going to post that Stevia tastes like crap when I saw your post. I agree!

Splenda is the one I use.


29 posted on 06/06/2021 12:35:00 AM PDT by jonrick46 ( Leftnicks chase illusions of motherships at the end of the pier.)
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To: ConservativeMind

“The “studies” were not the most legit:”

Neither is that website you linked. That website is owned by LeRoche Benicoeur which after years of BBB complaints has finally had the FDA step in to shut down the scam.
https://www.ftc.gov/system/files/warning-letters/fda-conceivemedia.pdf

A company who profits off of the fears of women who feel they have fertility issues would never push info that might affect their fertility in a negative way, right? From their website: “Hundreds of other researchers have done studies on stevia since these two studies were done, and none noted any side effects of the fertility variety, and actually none have noted any side effects at all.”

NO SIDE EFFECTS AT ALL and yet how many posters on this very thread report headaches/migraines? Thousands of researchers HAVE BEEN PAID to report that global warming is real so we all need to fall in line with the globalist agenda but that does not make it true. The fact that studies were paid to be done after the Ehrlich book came to light just means that those funding the studies got what they paid for. If the last year has taught anything, don’t be so quick to “trust the science.” I trust the antidotal evidence of hundreds of years of native women who figured it out on their own just as I would not chew on a yucca root during the first month of pregnancy if I wanted to keep the child.


30 posted on 06/06/2021 4:40:19 AM PDT by anonsquared
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To: anonsquared
The FDA has accepted GRAS status for 95+% purified extracts. Cruder extracts or even whole leaves are not brought into the country.

An interesting evaluation of the GRAS approach taken for these extracts is here:

https://pubmed.ncbi.nlm.nih.gov/30268795/

The article is free.

The paper ends with this comment, concerning all accepted GRAS notices for these compounds:

“With regard to safety, notifiers include data and information about the metabolism of steviol glycosides and the similarity of metabolism for all steviol glycosides in rats and humans. Estimates of dietary exposure to stevia-derived ingredients are within JECFA’s established ADI of 4 mg/kg bw/day on a steviol equivalents basis.”

That amount is roughly nine packets of purified extract a day for a 160 pound person.

31 posted on 06/06/2021 9:02:51 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: CondoleezzaProtege

one of the main problems is excess consumption of fructose that’s found in high-fructose corn syrup and various other sugar mixtures, including sucrose, honey and maple syrup ...

fructose is metabolized in the liver almost exactly the same as ethanol, and excess consumption of fructose is the leading cause of Nonalcoholic Steatohepatitis (NASH), an inflammatory condition similar to the cirrhosis caused by excess ethanol consumption ...

https://stanfordhealthcare.org/medical-conditions/liver-kidneys-and-urinary-system/nonalcoholic-steatohepatitis-nash.html


32 posted on 06/06/2021 9:03:01 AM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: catnipman

Yes. My time abroad revealed to me that other cultures indulge in sweets, but don’t have problems to the extent America does due to having banned ingredients like HFCS. Including in ketchups, soft drinks, etc...

And things like honey and jams are way less processed.


33 posted on 06/06/2021 9:05:28 AM PDT by CondoleezzaProtege
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To: ConservativeMind

Thanks for the link. Not sure I trust the FDA to look out for the best interests of the American people.

Anyone looking for an alternative to highly processed sugar should give date syrup a try. Low glycemic index, loaded with magnesium, potassium, and antioxidants.

https://www.justdatesyrup.com/


34 posted on 06/06/2021 9:14:38 AM PDT by anonsquared
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