Posted on 05/03/2021 9:37:52 AM PDT by zek157
THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS
Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease HOME - SALK NEWS - THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS SALK NEWS
April 30, 2021 The novel coronavirus’ spike protein plays additional key role in illness Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease
LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.
The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.
Representative images of vascular endothelial control cells (left) and cells treated with the SARS-CoV-2 Spike protein (right) show that the spike protein causes increased mitochondrial fragmentation in vascular cells. Click here for a high-resolution image. Credit: Salk Institute “A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”
Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.
While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.
In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.
The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.
Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.
“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”
The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.
Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xi’an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xi’an Jiatong University Health Science Center in Xi’an, China.
The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong University
“Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.
“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.””
WOW, It’s a good thing we are not injecting people with experimental mRNA to prompt their cells to produce copious amounts of of this same spike protein...
Oh... WAIT...
From what I know - if not for Fauci none of this would be happening. Him and his “gain of function” virus manipulation paid for by our tax dollars - supposedly to create a vaccine for a future potential disease.
Monster!
He’ll be moving to a remote island with his billions of dollars to escape the wrath of his role in this evil scheme.
The spike protein shedding appears to be the reason unvaccinated women working in close proximity to vaccinated women are report problems with monthly cycles.
“The mRNA “vaccines” turn the “vaccinated” into mobile spike protein factories.”
Do you have medical sources for this? Also, are you a medical professional?
By the way, take a few minutes and watch this doctor discuss the possible effects of the vaccine.
If bad protein folding causes diseases like Kuru, Mad-Cow and CJD....
How can they assure us 100% that turning everyone’s cells in to experimental mRNA protein producing factories is ALSO going to ensure that every cell that is infected with this mRNA is going to FOLD EVERY SINGLE PROTEIN the way it is supposed to be FOLDED?
THEY CANNOT!
Just look at the animal trials of mRNA vaccines....
Look at the fact that corona viruses cannot be easily defeated specifically DUE TO THE FACT of the spike proteins on their surface which are so similar to other proteins in the body. This is precisely WHY there has never been a “cure” for the common cold.
They are creating a potential auto-immune storm by targeting this “spike” protein the way they are.
If this spike protein was so dissimilar to other things in the human body.... The Human immune system would have easily defeated it LONG AGO!
The best course against this disease is whop we have ALWAYS fought corona type viruses....
BY REINFORCING THE HUMAN BODY, using Vitamin C, Chicken Soup ( contains lipids and nutrients the body needs ), symptom reducers, etc etc....
Not by turning the body’s immune system against itself...
Hi.
Wouldn’t the “gain of function” virologist in China (Wuhan), the Bat Lady, Dr. Zhi Zhengli be able to help in this pandemic?
I wonder if Dr. Fauci knows where she is?
Or, if she is still sucking O2.
5.56mm
Agreed
That being said in terms of the technical analysis on COVID-19 there are a lot of actions by government worldwide which lead one to a much broader interpretation of this is a communist plot
[ The lipid capsule wrapped around the mRNA from Pfizer and Moderna products can cross the blood/brain barrier. The consequence is manufacturing spike protein in the brain. There are ACE receptors in the brain, so there is room for the mitochondial damage discussed in the lead article to occur. There is also the prospect of protein misfolding into prions in the brain. That would be the genesis of the spongiform encephalopathy. ]
That is a scary as hell, if we see a spike in early onset dementia in “vaxxed” people under the age of 40 we will know what the hell caused it...
Of course we will be called “Conspiracy Theorists” for our trouble...
So, you are both more inclined to favor the J&J vaccine?
The instructions contained in the mRNA vaccine tell cells within one’s body to make the corona spike protein. Idk how long this lasts, but that is the basic premise of activating your immune system to covid. I’m sure most people will be ok, others will be on their own as manufacturers have zero product liability.
“When you look at images of the coronavirus, you see spikes sticking out from all sides; these spikes are actually proteins. The mRNA vaccines for COVID-19 contain the instructions cells need to make a piece of the spike protein but not the fully functioning COVID-19 virus.
The formation of these spike proteins tricks your body into making an immune response against the spike protein, which works to protect you against the COVID-19 virus if you are exposed to it. This immune response is what gives you protection against the disease”
Bttt.
5.56mm
Vaccines against stable pathogens e.g. smallpox, rubella, diphtheria, whooping cough, typhoid and tetanus work well. I have no objections to their use. SARS-CoV-2 is a rapidly mutating pathogen as a consequence of being an RNA virus. Attempting a vaccine is a fool's errand.
“ Idk how long this lasts”
A few days
Exactly.
You’ll be called a conspiracy theorist and these drug companies....and, all of the agencies who pushed these shots, will have immunity.
How great is that?
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