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THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS
SALK ^ | April 30, 2021 | SALK

Posted on 05/01/2021 4:56:45 PM PDT by Cathi

THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS

If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID

The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.

“That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902

(Excerpt) Read more at salk.edu ...


TOPICS: Health/Medicine
KEYWORDS: bioweapon; chinavirus; circulationresearch; covid; dsj03; fauciflu; gainoffunction; salk; salkinstitute; spikeprotein; vasculardisease
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To: one guy in new jersey

21 posted on 05/01/2021 5:40:35 PM PDT by EEGator
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To: ransomnote

“This is false.”
_______

Explain why, if you please.

Nothing that came after this phrase seemed to one guy to support the assertion you made.


22 posted on 05/01/2021 5:41:04 PM PDT by one guy in new jersey
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To: Cathi

I posted the following research months ago. They were warning about the Spike protein by itself being a potential pathogenesis of various diseases and urging animal studies be done.

“We will need to monitor carefully the long-term consequences of COVID-19 vaccines that introduce the spike protein into the human body.

Furthermore, while human data on the possible long-term consequences of spike protein-based COVID-19 vaccines will not be available soon, it is imperative that appropriate experimental animal models are employed as soon as possible to ensure that the SARS-CoV-2 spike protein does not elicit any signs of the pathogenesis of PAH or any other chronic pathological conditions.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827936/


23 posted on 05/01/2021 5:45:45 PM PDT by Cathi
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To: Jim Noble
and I don’t think people in the US or Western Europe would have done it under any circumstances anyway.

It's a lot easier to impose draconian mitigation measures in a communist dictatorship. They were welding people's doors shut so they could control traffic on and out of apartment buildings.

But voluntary isolation, voluntary quarantine, and treating all public spaces as if they carried equal risk had enormous cost and zero benefit. It was foolish and wasteful, and the people responsible for our ineffective and harmful policy should be held to account.

We had no idea what the actual risk was initially. To a large extent, we still don't. And of course there was the politics. Politics tainted every aspect of our response-another problem not found in a communist dictatorship. They wanted the economy to crash. They wanted dead Americans. They wanted Trump to fail. This was their agenda throughout 2020. It tainted everything.

24 posted on 05/01/2021 5:47:00 PM PDT by RC one (When a bunch of commies start telling you that you don't need an AR15, you really need an AR15)
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To: Jim Noble

Don’t confuse design and effect. The design is gain of function. The effect is TBD. The fact that the design and effect make it an effective bioweapon are happenstance, not design.


25 posted on 05/01/2021 5:50:39 PM PDT by MortMan (Shouldn't "palindrome" read the same forward and backward?)
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To: one guy in new jersey
I couldn't find the compact link that would save some pixels, so I'll paste my response to someone in a debate below the line, which contains links etc.

Basically, since they don't use the actual virus for the vaccines, the PCR test, the 'variants', we can be certain they couldn't be relaying accurate research for the spike protein on the virus.

Fauci and the NIH helped the vaccine manufacturers (Fauci and 6 others share ownership of Moderna patent) 'select' the spike protein the vaccines would produce. They used the genome of the virus which China released to us in January 2020. That genome can not be accurate. China used gene sequencing that patches in missing data from other corona viruses wherever there are gaps.

From the start, they've declared the virus for covid to be a 'novel' virus, which by definition means other virus sequences do not match it.

Why would China release the China virus from the Wuhan labs and then give the world the accurate genome for it to fight it? They are our enemies and they gave us something to use but it wasn't for our own good.

SO the argument goes back to the fact that China, NIH, PCR, vaccines are based on an inaccurate genome. Then research surfaces saying the spike protein on it is toxic just as the world is dealing with the toxic effects of vaccinations which they claim produce that same spike protein.

The lies, the lockdowns, the censorship all to protect China's real biowarfare agent - the vaccines.

~~~~~~~~~~~~~~~~~~~

Why don’t you instead read about the actual virologists who actually have isolated it? Not particularly difficult to find the information, and it was widely discussed here since the start of the pandemic. It’s been done countless thousands upon thousands of times by this point:

~~~~~~~~~~~~~~~

ransomnote: Because it hasn't been isolated.

I'd been reading virologists and others who've said that there are no isolated samples. Trolls become unglued and one provided a 'timeline of who had it when etc." No links, of course.

But China has bought off researchers, labs etc. who will say they've used the isolated samples. FReeper Magic Bullet did some research of his own. (I think it's the second link) by calling and searching FOAI etc.

https://freerepublic.com/focus/chat/3945205/posts?page=93#93

https://freerepublic.com/focus/chat/3945205/posts?page=95#95

Someone gave me 'proof' that isolated examples exist but I searched the article and found that that person works with Fauci's NIH, which is thoroughly compromised.

When the deep state closed ranks against President Trump  falsely declaring evidence proved him guilty of the Russia Hoax, the MSM bathed us in links, video, testimony etc. for over a year.

Yet what you have a is just that set of links 'proving' that researchers have isolated samples everywhere? THey're just phoning it in.

China says it didn't use live cells to create the genome, but it's supposed to be a 'novel virus' so the technology CHina said it used to 'map' it won't work because that technology is based on predictable/traditional Corona viruses.

The vaccine manufacturers say they didn't base their vaccines on live virus. Fauci indicates 'we' managed to get to phase 1 trials in just 3 months from when we 'got' it (i.e., from China). 

The papers I've read claiming research on the live virus link back to NIH, Wuhan etc. and those are the ones claiming they are researching the actual virus. 

The CDC's own documentation dated 12/1/2020 says the PCR 'test' was developed without isolated samples because none was available:

*CDC 2019-nCoV Real-Time RT-PCR Diagnostic Panel - Instructions for Use (fda.gov)


So supposedly 'everybody had isolated samples, all the time, everywhere, all day ,everyday but no one was actually using them, and researchers not on the iside can't get samples, ever. STill.

You are not aware that there were multiple dress reheasals for our enemies coordinating the messaging internationally and right down to social media (how to silence people) for this planned-demic having to do with how to control communications.

This one is the creepiest:

The SPARS Pandemic of 2025-2028” from Johns Hopkins Bloomberg School of Public Health Center for Health Security [my comments and link to PDF] (freerepublic.com)

All about how to capture the narrative and control it among the planned-demic players. So I'm not the least bit suprised someone can post links to people who say they've been doing this research for ever and 1000s of times while researchers keep saying when they ask for samples, they are told none exist.

There are several other international training excercises - this level of power grab world-wide took tremendous planning: On page 49 of the following document, a progress indicator included a training scenario of a lethal respiratory pathogen deliberately released:

GPMB_Annual_Report_English.pdf - pCloud

Since you are not acknowleding the information at the two links I provided up thread (h/t magic bullet) and at the top of my post, I'll repeat the content here. Basically, those who say they have the genome, have purified the genome, are not telling the truth. This scam-demic wouldn't have gotten as far as it has without the kind of planning to fake communications. 

~~~~~~~~~~~~~~~

Post #1

The CDC only made a cell culture of ONE PATIENT, its a mix of many biological materials, not purified, ie never did a density gradient, its not a biologic isolation. BEI Resources sells many Sars Cov 2 so-called isolates, but they are unpurified cell cultures (I asked them, did you?). Neither Metagenomic study nor EM photos tells you what is really in a mix of soup.

The first case was ONE PATIENT from Wuhan, whose lung wash had a metagenome analysis. This is based on a few primers referencing a data base filling in most of the rest of the genome from a computer generated database RNA sequence, easily fudged, and sent to a gene bank that day with a lengthy complex paper by Zhang et al sent for publication in 2 days (really?) to Nature. Metagenomics are only supposed to be done only on well-characterized organisms, and the NOVEL corona virus is not one of these.

This gene accession number was then used as the template for the PCR (see FDA pcr manual that stated no isolates were available), and the Pfizer etc vaccines (see on line FOIA requests stating the vax was not based on the RNA of an isolated virus from a living patient). See, the head of the China CDC also said the problem is the virus has never been isolated.

So the test finds the same genome its based on, because thats how its programmed. Now, lets just vax 8 bil people based on this baseless data with mRNA made to a spike protein the computer made up, just coincidentlly also maps to a placenta protein.

There cant be an isolate to find or purify because then the whole narrative of the virus and later mutations, PCR, and Vaxes, would fall apart. Thats why there are many papers doing cell culture, metagenomic or PCR testing, and EM photos but NO DENSITY GRADIENT purification. Do you get whats happening?

~~~~~~~~~~~~~~~~~~~~~~~~~

Post #2

They say they have used metagenomics to sequence (by a co called Illumina) the sample of sludge (lung wash) they say they got from patient one in Wuhan. Nature paper:
https://www.nature.com/articles/s41586-020-2008-3
This paper at top says it was submitted on Jan 7th 2020 and was accepted on Jan 20th 2020-only 9 business days later.

A later paper in March in Cell (published just to repeat the story of the first paper),
https://pubmed.ncbi.nlm.nih.gov/32220310/
says:“Fortunately, next-generation metatranscriptomic sequencing enabled us to obtain a complete viral genome from this patient on January 5, 2020”.
Looking at the dates, they wrote up the Nature paper and submitted it and a gene accession no to a gene bank within 2 days. I personally suspect this paper is just written up and not real because this long paper must have been written in advance, and it is the first train car in train that all the others must follow because they made the gene sequence as the base.

The entire PCR and then the Vax genome was determined from this ONE CASE based on the same gene accession no. The FDA said there were no isolates available in its PCR spec paper, the Chinese NIH Head said on video “we did not isolate the virus”, and Pfizer replied to FOIA requests the genome it uses as base for the Vax did not come from an isolate from an infected person? I omit the links here as they are easy to look up yourself.

To determine the exact pathogen, and where any lab would be able to INDEPENDENTLY reproduce isolation and confirm the pathogen claims and vax makers contents are appropriate, we need an isolate where the whole genome can be sequenced and the isolates can be shown to be from patients with similar pathology, and that these PURIFIED isolates can cause the same histologic changes in tissue cultures (preferably in humans or an animal similar to a human as study in humans is an ethical problem-not to mention that vaccinating the entire world with an experimental vaccine is a much bigger ethical problem), but there are no purified isolates....

Metagenomic problems:
1. Metagenomic sequencing of a mixed sample uses primers and then fills in the rest of the genome “in-silico” meaning in a computer program (i.e. on paper) based on a gene library (this is the part that can be fudged). Now you can get any sequence you like and set your PCR test based on the genes in that which may actually cross-react with other things (see links in my posts above).
2. Because of this, Metagenomic sequencing is only supposed to be done on organisms that have already been well characterized. How can a novel Corona be well characterized? Scroll to the image on the left about 1/3 way down from this top link:
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/metagenomics
https://www.nature.com/articles/s41564-019-0637-9

So now you can have labs reproduce cell cultures and define the pathogen based on a metagenome, and/or a PCR based on the metagenome now matched to the gene library you have yourself made up. If there were purified isolates on the market or reproduced independently then the whole story would crumble because the fudged part leads to faulty PCRs and vaxes that can have mRNA or DNA that leads to certain effects that would not be in a virus but could be in a genome you make in silico. Nobody makes isolates because there is no virus to make an isolate from, its just a positive PCR test or metagenome primers looking at a bunch of gook or cell-cultures you can buy that will lead you to the same place in the gene bank that you made up to begin with, and now you can make variants in-silico, and on and on.

BEI Resources makes and sells a few dozen covid “isolates”. I asked them if they isolated and purified the viruses, they replied the isolates are only cell culture lysates. Bacteria and fungi are usually killed off. Mix of viruses are left. If you use PCR on these you will of course find Covid because that’s the only place on the map the pcr leads.
Maybe they have other corona’s in them for the E-M photos and to detect primers that lead to the gene bank for sars cov 2, this part is my conjecture.

Reply from BEI Resources, biggest US maker of so called isolates:

———————
None of these products are really purified. Each of the virus strains are provided as cell lysate and supernatant. They definitely will not have been separated into density gradients and this is not something we would have tested for during the course of the normal QC and Authentication testing for these items.

Walter Usener
BEI Resources
Customer/Technical Services
Administered by ATCC
10801 University Blvd
Manassas Virginia, 20110-2209
Email: Contact@BEIResources.org
Phone: 800-359-7370
————————–

They also told me they have no info on anyone who ever isolated and purified the virus from these cell cultures that only have inactivated viruses they say. Now you know that the word ISOLATE can be corrupted to any meaning you want.

Metagenomics is the bionic man of genetics, Part biology (but can still be faked), mostly made from silicon.

~~~~~~~~~~~~~~~~~~~~~~~~~~

ransomnote:

~~~~~~~~~

Aren't you the least bit curious where 38 million cases of the flu went last year?

Just a tiny bit?

26 posted on 05/01/2021 6:05:14 PM PDT by ransomnote (IN GOD WE TRUST)
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To: Cathi
The Beatles once had a song about a would-be paperback writer. Did the guy get a job naming diseases?

The novel coronavirus.

I'm looking forward to when it is replaced by the short story coronavirus, then the paragraph coronavirus and finally the aphorism coronavirus.

27 posted on 05/01/2021 6:12:59 PM PDT by Verginius Rufus
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To: RC one

“We had no idea what the actual risk was initially. To a large extent, we still don’t. And of course there was the politics. Politics tainted every aspect of our response-another problem not found in a communist dictatorship. They wanted the economy to crash. They wanted dead Americans. They wanted Trump to fail. This was their agenda throughout 2020. It tainted everything.”

__________

They knew that, however brutal or repulsive the downstream consequences might be of their chosen course of action in 2020, by 2021 with the executive branch in hand they would be able to jam anything that tends to portray their 2020 role in any kind of negative light straight down the memory hole, furiously start to rewrite history in such a way as to blame their political enemies and assure them total impunity, and resume going forward with full stream to implement the atheistic, nihilistic, eugenicistic, satanic, marxist, Cloward-Piven, Saul Alinsky, deep state one-world-government policy nirvana 0bama and his friends and all of their nameless, faceless backers and puppetmasters have been dreaming about for decades.


28 posted on 05/01/2021 6:14:38 PM PDT by one guy in new jersey
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To: Cathi

This virus was created by injecting a spike protein into an animal virus to allow it to penetrate human cells when it was incapable of doing that before,just ask the man who did it after being told by Obama to stop the dangerous Gain Of Function Research,the Function Fauci was experimenting with was the function of Animal viruses to penetrate human cells that couldn’t before,they added a Spike Protein that allowed that to happen


29 posted on 05/01/2021 6:18:09 PM PDT by ballplayer
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To: Uncle Miltie

“Isn’t this essentially what the vaccine does?”

Not these RNA or DNA vaccines.


30 posted on 05/01/2021 6:40:23 PM PDT by ifinnegan ( Democrats kill babies and harvest their organs to sell)
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To: ransomnote

Okay then, how would you have reacted if this was the headline instead:

AS IT TURNS OUT, THE SPIKE PROTEIN THE mRNA GENE MANIPLATOON SERUM INJECTIONS ARE TEACHING THE BODIES OF PFIZER AND MODERNA PATIENTS TO PRODUCE IS, BY MISTAKE, NOT QUITE THE SAME AS THE SPIKE PROTEIN OF THE SARS-COVI-2 VIRUS, SO EVEN THOUGH THE FORMER IS UNEXPECTEDLY BEING FOUND IN AND OF ITSELF TO CAUSE NASTY SYMPTOMS AND ILLNESSES, YOU STILL SHOULDN’T HESITATE TO RECEIVE EITHER OF THOSE COMPANIES’ mRNA GENE MANIPLATOON SERUM INJECTIONS BECAUSE THEY REALLY ARE SAFE DONCHAKNOW


31 posted on 05/01/2021 6:45:56 PM PDT by one guy in new jersey
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To: Cathi

There is a whole class of drugs that bind to ACE2. Plenty of folk here probably take them.

https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/angiotensin-ii-receptor-blockers/art-20045009

This article is speculation on extremely rare cases and, typically for media, is exaggerated or distorted.


32 posted on 05/01/2021 6:47:49 PM PDT by ifinnegan ( Democrats kill babies and harvest their organs to sell)
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To: Cathi; Chauncey Gardiner; Uncle Miltie; RC one; silverleaf; one guy in new jersey
I have had my two shots at the VA center in White City Oregon and they gave me a fact sheet saying what was in the vaccine. They said:

Messenger ribonucleic acid (mRNA), lipids (SM-102, polyethylene glycol [PEG} 2000 dimyristoyl glycerol [DMG], cholesterol, and 1,2-disteaoyl-sn-glycero-3-phosphocholine [DSPC], tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose.

I don’t know about you, but it sounds like something my younger son would use to wipe down his duty pistol after cleaning it.

I’ve had no adverse reactions yet, but then I once tried to get drunk on mouthwash and kill the foot fungus I picked up in Vietnam using gasoline. After prospering in spite of those experiences, maybe my experience with the vaccine is not helpful?

33 posted on 05/01/2021 6:49:08 PM PDT by Retain Mike ( Sat Cong)
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To: ransomnote

Correction:

______

Okay then, how would you have reacted if this was the headline instead:

AS IT TURNS OUT, THE SPIKE PROTEIN THE mRNA GENE MANIPLATOON SERUM INJECTIONS ARE TEACHING THE BODIES OF PFIZER AND MODERNA PATIENTS TO PRODUCE IS, BY MISTAKE, NOT QUITE THE SAME AS THE SPIKE PROTEIN OF THE SARS-COVI-2 VIRUS, SO EVEN THOUGH THE LATTER IS UNEXPECTEDLY BEING FOUND IN AND OF ITSELF TO CAUSE NASTY SYMPTOMS AND ILLNESSES, YOU STILL SHOULDN’T HESITATE TO RECEIVE EITHER OF THOSE COMPANIES’ mRNA GENE MANIPLATOON SERUM INJECTIONS BECAUSE THEY REALLY ARE SAFE DONCHAKNOW

_______

got former and latter mixed up!


34 posted on 05/01/2021 6:50:08 PM PDT by one guy in new jersey
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To: Jim Noble
Potentially engineered

Most certainly engineered for "gain-of-function". What functions were they trying to gain? This research was abandoned in Toronto, Canada in 2015 because the executives believed it to be too dangerous to continue. The Chinese picked all the materials and ran with them. Why?

Most likely they developed an early-stage prototype which was accidentally released from a bio-weapons research lab in late September 2019. Another possible (and accidental) release may have occurred in 2018.

- it it’s a little bit sci-fi like to believe a lab in 2019 exists that could execute a design at the level proposed by the bio weapon crowd.

That capability clearly does not exist at this time. It would take a lot of dangerous research to develop such a capability. Mistakes happen in dangerous research. COVID-19 is likely the result of one such mistake.

It is quite easy to believe that the Chinese are trying to develop an ethnic-specific plague that would exterminate non-Chinese populations. They have repeatedly published speculations about such things in their official military journals.

It is quite easy to believe the Chinese attempted such a program at Wuhan and failed in their early research attempts.

In the Stephen King novel "The Stand", there was a graffiti left on the wall of the bio-weapons lab by the doomed scientists:

"Now you know it works. Any questions?"

35 posted on 05/01/2021 6:51:32 PM PDT by flamberge (I'm in the control group - the ones that are not getting the mRNA treatment)
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To: one guy in new jersey

And what the heck is a MANIPLATOON?

__________

MANIPULATION


36 posted on 05/01/2021 6:52:54 PM PDT by one guy in new jersey
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To: RC one
Was it their extreme mitigation measures?

Only a totalitarian government like China could pull it off. (Honorable mention: North Korea)

37 posted on 05/01/2021 6:54:22 PM PDT by MinorityRepublican
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To: one guy in new jersey

CORRECTION to YOUR CORRECTION.

THe title should read.

IGNORE REPORTS THAT THAT THE COVID-19 VIRUS PRODUCES HARMFUL SPIKE PROTEINS, EVEN THOUGH EXPENSIVE RESEARCH IN PREVIOUSLY REPUTABLE PUBLICATIONS CLAIMS IT DOES. THEY ARE JUST CLAIMING THAT TO PANIC THE PUBLIC INTO GETTING THE FAKE VACCINES WHICH HAVE THE REAL HARMFUL SPIKE PROTEIN YOU SHOULD AVOID.

As the vaccines cause harm, the Deep STate handlers tell us it’s the virus instead, to frighten people into getting the vaccine and cover their crimes against humanity.


38 posted on 05/01/2021 6:59:43 PM PDT by ransomnote (IN GOD WE TRUST)
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To: algore

Oddly, Mr. Gore, I think you have the best take on this, despite your carbon footprint.

We are started down the path of humans needing the government injection in order to live. The lethality of this ChiCom virus will increase and deliberately inadequate vaccination measures will insure this.

Strange that Russia let the dog so far off the leash.


39 posted on 05/01/2021 7:07:30 PM PDT by Empire_of_Liberty
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To: Verginius Rufus

Rufus,,,
I just wanted a Name
Like Yours..
Long story short.


40 posted on 05/01/2021 7:09:02 PM PDT by Big Red Badger (Be Still and Know that I Am God. Rev 19)
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