Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

American Journal of Therapuetics ^ | May-Jun 2021 | Kory, Pierre MD; Meduri, Gianfranco Umberto MD; Varon Joseph MD; Iglesias, Jose DO; Marik, Paul MD

[SeekAndFind]

Abstract

Background:

After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.

Areas of Uncertainty:

The majority of trialed agents have failed to provide reproducible, definitive proof of efficacy in reducing the mortality of COVID-19 with the exception of corticosteroids in moderate to severe disease. Recently, evidence has emerged that the oral antiparasitic agent ivermectin exhibits numerous antiviral and anti-inflammatory mechanisms with trial results reporting significant outcome benefits. Given some have not passed peer review, several expert groups including Unitaid/World Health Organization have undertaken a systematic global effort to contact all active trial investigators to rapidly gather the data needed to grade and perform meta-analyses.

Data Sources:

Data were sourced from published peer-reviewed studies, manuscripts posted to preprint servers, expert meta-analyses, and numerous epidemiological analyses of regions with ivermectin distribution campaigns.

Therapeutic Advances:

A large majority of randomized and observational controlled trials of ivermectin are reporting repeated, large magnitude improvements in clinical outcomes. Numerous prophylaxis trials demonstrate that regular ivermectin use leads to large reductions in transmission. Multiple, large “natural experiments” occurred in regions that initiated “ivermectin distribution” campaigns followed by tight, reproducible, temporally associated decreases in case counts and case fatality rates compared with nearby regions without such campaigns.

Conclusions:

Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.

CLICK ABOVE LINK FOR THE DETAILS OF THE STUDY

[high info voter]

The lies and fraud of this "Covid-19 pandemic" we're so terrible!

Since the beginning there were preventatives out there, there were cures out there, and there were screwed up numbers out there that made it into a phony pandemic!

and once again the American people are not pissed off enough to look into it!

[Eagles6]

I bought a bunch at Tractor Supply last year...just in case I find a pony in that load of horse manure I get every Christmas.

[Wuli]

Yes, treatments over vaccines.

[Saber6]

Hi SeekAndFind! A roughly 20Y lurker here, but had to go official to share this information.

Since early 2020 I have prepared for covid by having on hand several things: Vitamin D, vitamin C, Zinc, Quercetin, etc. I also, based on the very early evidence, procured an Ivermectin product intended for “off label” use in a break glass situation. Well, that situation arrived on Tuesday 4/27.

Background: My father-in-law was hospitalized for roughly a month for non-covid issues. During that time my wife was visiting the hospital daily. During her visits she would smartly wear a mask (which we now all know is not effective), wash her hands, etc. In our minds, a hospital is a place you can surely find covid if it’s around. So we were concerned, but for days, nothing. That’s great, right?

Anyway, FIL was released on Monday 4/26. Wife stayed overnight at his house that night. Late in the evening she had a bout of vomiting and gastro issues. Everyone assumes food poisoning since they ordered take out, but they shared the meal, so unlikely.

I am a teleworker, and so was there when my wife came home at around 9:30AM. Walking down the driveway, she looked rough. She came in and told me the story about being sick overnight. She otherwise felt fine. At about 10:15 AM, she said she was going to lay down and rest.

Now for the good stuff.

11:00AM, I checked on her and she merely stated “I’m sick”. Ok, I’ll check on her in a bit.

At roughly 12:15PM, I check in on her and she’s in full blown distress. Severe full body ache. Fever. Sweating. Cold. Headache. I’m forgetting some symptoms, I’m sure, but she had them all. It’s either covid (probably) or flu (not flu season), but it did not matter. Her progression was scary and fast. I told her she was about to get dosed, and she was so sick she could not even object. At approximately 12:30PM, I administered a “150lb dose” of Ivermectin.

Within one hour, body aches cleared. Overnight, she had sweats and fever, but by morning it had broken.

Morning of 4/28, miraculously improved. We were shocked. But, still “sick”. That day, administered “100lb dose”. Also, D, C, zinc, quercetin.

Morning of 4/29, further improved. Happy and amazed patient, but still “getting over it”. That day, administered “100lb dose”. Also, D, C, zinc, quercetin.

Morning of 4/30, wife had recovered almost completely, but, we continued with our plan of five days of doses. Again gave a “100lb dose”. Also gave D, C, zinc, quercetin.

She’s still sleeping today, but I’m sure she will wake up fine and healthy. She’ll get a “100lb dose” again today + the vitamins mentioned, just because.

So, think of this timeline: Severe illness on a Tuesday - effectively cured on Friday.

I find it rather miraculous.

Some additional notes:

- I have been taking D, C, zinc, and quercetin daily. My wife has not.

- I also “felt” the sickness, but it never took hold of me at all. Oh, BTW, I took a single “150lb dose” on Tuesday, and another on Thursday. Treating the flock!

- I’ve been interrogating my wife about her symptoms and severity of those symptoms all along. She would “feel” the illness progress much like a flu. In her nose, in her throat, etc. But in each case, unlike with flu where you take the full force as the illness runs it’s course, it would be there, and then gone, as though it could not take hold and was beaten.

- Regarding the headache, it arrived for her on Monday 4/26 and was continuous and severe from Monday - Wednesday. Tylenol would not break it. On Thursday it disappeared.

So, there you go folks. I’ve “gone there” and it saved my wife from severe illness. No side effects. No problems. Whether covid or some flu, Ivermectin stopped it cold. In my observation, it’s as though it allowed her to skip the first 7 days (or more) of a bout of flu. I hate the flu and now have a plan for the future.

No way I’m taking the jab given the evidence, science, and direct observation of the effectiveness of Ivermectin as a means to deal with covid.

I’m sure many of you Freepers have seen all of information indicating Ivermectin could help with covid. I am now bringing you first hand proof that it works.

Note that I am not a doctor, and my comments should not be taken as medical advice.

Best Regards

Saber6

[SeekAndFind]

Thank you for sharing your experience in this thread. I’d like to spend some time reviewing it since your post is quite long. I hope you don’t mind if I ask some relevant questions later after I digest your post.

[crusher]

An excellent observational report. Thank you.

[gitmo]

Both prophylaxis and treatment. 2 people in my family were already positive.

I still came down with COVID despite taking the Ivermectin, but it was like a bad summer cold.

My wife, however, had a difficult time. She has been on HCQ for decades, and started Ivermectin as soon as she tested positive.

One of my sons was among the initial positives. He took the Ivermectin, and never had any symptoms.

[Faith65]

Thanks for posting this!

bkmk

[Saber6]

Of course, and apologies to all for the long post and poor formatting. The context was important and these details are my small way of giving back to the community that helped me identify and understand effective covid mitigations.

Shortly I may return to lurking, but I’ll be sure to my part and submit a donation imminently.

[ransomnote]

Admin,
The link to this article is dead. Here is the new link for the same article:
https://journals.lww.com/americantherapeutics/fulltext/2021/06000/review_of_the_emerging_evidence_demonstrating_the.4.aspx