Nice catch. 
Posted on 04/20/2021 5:44:23 PM PDT by nickcarraway
The three COVID-19 vaccines authorized in the United States may be key to helping get the pandemic under control in the near future.
But while these vaccines, released by Pfizer-BioNTech, Johnson & Johnson, and Moderna, are effective, they do come with some challenges.
All require getting an injection, which can make people with needle phobias extremely hesitant to get the shot. Additionally, side effects including feelings of fever, flu-like symptoms, and arm soreness are common with all three vaccines.
The Johnson & Johnson vaccine has been paused as officials investigate extremely rare blood clots that may be associated with the vaccine.
To make the vaccination process simpler and faster, researchers are working to develop the next generation of COVID-19 vaccines, namely in pill and nasal spray forms.
These next-generation vaccines may make it easier to eradicate the coronavirus from the globe.
What we know about the next generation of COVID-19 vaccines so far “At this time, SARS-CoV-2 vaccines are injectable. Several vaccine manufacturers have started initial development of a nasal vaccine spray,” said Dr. Javeed Siddiqui, co-founder and chief medical officer at TeleMed2U.
“Nasal spray vaccine could be available as soon as 2022, however this is highly variable based on clinical efficacy and vaccine effectiveness in clinical trials,” he said.
Siddiqui added that future vaccine generations are anticipated to include activity against variants of the virus.
According to FasterCures, a center of the Milken Institute that’s currently tracking the development of COVID-19 vaccines, five companies are developing oral vaccines. Two of these companies have moved on to phase 1 clinical trials.
Of the 13 companies working on a nasal spray vaccine, five are in early clinical trials.
“It’s exciting. It speaks to the innovation that scientists, government, and academia are working to improve what we have,” said Dr. William Schaffner, an infectious disease expert at Vanderbilt University and the medical director for the National Foundation for Infectious Diseases.
“What we know from the current vaccines are which parts of the virus are important in order to stimulate an immune response,” he said.
Watch Lesley Stahl, Alyssa Milano, D.L. Hughley & more as they recount the past year and look ahead to the future. Watch our insightful and uplifting conversation on hope, vaccines, mental health & more.
How the original COVID-19 vaccines work
According to the Centers for Disease Control and Prevention (CDC)Trusted Source, the current COVID-19 vaccines help our bodies develop immunity by supplying them with “memory” T-lymphocytes and B-lymphocytes. These white blood cells remember how to fight the coronavirus, should it enter your body in the future.
Currently, three types of COVID-19 vaccines are authorized in the United States, although the Johnson & Johnson vaccine has been temporarily paused as it potentially triggered a rare blood clot in a very small percentage of the population.
One vaccine is the mRNA vaccine. It contains material from the virus, which instructs our cells to make a protein unique to the coronavirus to fight it in the future.
Another vaccine is the protein subunit vaccine. It includes harmless proteins of the virus instead of the entire germ. After vaccination, the body recognizes the protein and will remember how to fight it.
The third type is the vector vaccine. It contains a modified version of a different virus. Inside the shell of the modified virus is material from the coronavirus. Once the viral vector is in the cell, the cells produce a protein and then copy it, which prompts our bodies to build the T- and B-lymphocytes that can protect against the coronavirus.
How a nasal spray or pill could protect you from COVID-19
ImmunityBio, one of the companies working to develop other versions of the COVID-19 vaccine including a capsule and a dissolvable tablet, has been authorized by the FDA to expand a phase 1 clinical trial.
The three injectable vaccines (Pfizer-BioNTech, Moderna, and Johnson & Johnson) prompt the immune response to generate antibodies that fight against the coronavirus spike protein.
The ImmunityBio vaccine, however, targets both the mutation-prone outer spike protein and the more stable inner protein, which activates antibodies, memory B cells, and T cells against the coronavirus.
The goal is to create longer-term protection as well as provide protection from variants.
Altimmune is another company working on a next-generation vaccine. This one would be a nasal spray.
A nasal delivery method is designed to produce an immune response at the point where the virus enters the body, causing mucosal immunity in the nasal cavity.
Called AdCOVID, the nasal spray vaccine is designed to stimulate an immune response including both antibody and T-cell responses in the nasal cavity.
What will the next generation of vaccines mean for the future of COVID-19? At this point it’s too early to know whether these vaccines will be as effective as the first round of injectable vaccines.
But past cases have shown that an original injectable vaccine can be followed by oral versions.
In 1953 the polio vaccine was introduced as an injectable. Nine years later an oral version was developed, which essentially wiped the poliovirus from the planet.
“We’re right on the edge of eliminating [polio] from the world. We’re doing something similar with an oral vaccine against rotavirus. We had a nasal flu vaccine, although that had its ups and downs,” Schaffner said. “It’s not a straight line here, but there are precedents.”
New vaccines that are easier to administer and target virus variants can only mean there’s potential for eradication of the coronavirus, or at least an easier way to prevent infection or lessen its effects.
“If you could deliver vaccines by an effective nasal spray or a pill, you could deliver vaccines safely to a huge number of people very quickly. You won’t need to have trained people to give injections. All issues of using needles and syringes safely would disappear,” Schaffner said.
Being able to store the vaccine at room temperature would also make it much easier to administer.
This was your actual statement, hardly a simple question.
And yes, I am a licensed and practicing physician. What I find more curious is your bald face lie that you try and walk back as a question. Care to speak to this?
Impressive.
Equally impressive is how much a FOUR BOARDED, highly trained (obviously in very high demand, as a critical care anesthesiologist) has time to even think about posting on a chat forum, day after day, and almost EXCLUSIVELY on China virus shots threads.
I just can’t picture any of our physician friends (admittedly, not all are as highly trained/in demand as you surely are) having time, or energy to do that.
I’ll never forget one of your posts apologizing for a minor mistake you’d made. You offered that you’d just come off of a 30 (?) hour/very long shift, and you were foggy.
I was amazed that you had been able to post, nearly every half hour, to hour, here on experimental shots threads, during the previous 36 hours!
I couldn’t decide if I was super impressed, or super sympathetic, for all of those covid patients, that you mentioned, under your care.
The Almighty says don’t change the subject, just answer the friggin question. Are you or are you not a licensed and practicing MD?
Third time’s charm. Simple yes or no is all it takes.
I find it equally amazing that you would deride me for posting on a chat forum. I post on other topics, so clearly you are not engaged in actually looking at the truth. I am not allowed according to you to look at a forum I have been a member on for over 20 years? Really. There are obviously things you cannot defend because attacking me on my schedule seems suspect.
How about trying to defend your statements. When one has little to actually respond with, one engages in ad hominem attacks.
I answered your question sin my previous post. But you seem triggered in having your own words shown to be a lie. Are you able to comprehend the answer to the question in the above post? Third times a charm right back at you. You actually seem not to have a command of the language when you say still pretending to be a doctor is a legitimate question. Funny.
See post #41, the answer is clearly in there. Here is your actually rejoinder. So, are you capable of reading and comprehending? Or just throwing around insults? Not used to having your own words sed against you? Sad.
Nice catch.
Oh, sorry gas. I sure seem to have hit a nerve. 🤔
So as a licensed and practicing MD, you are giving free medical advice on an open forum? Do have any idea how actionable that is should somebody have an adverse reaction following your medical advice? If I am not mistaken, that is called malpractice and anybody who follows the advice of an anonymous “doctor” in an open forum is a fool, and anybody doling out professional medical advice anonymously is not just a fool but also a fraud.
You may be a nurse at best, but certainly not a doctor. I’m actually thinking you’re probably just a receptionist.
I was unaware I had to ask your permission to post. I guess you are the gatekeeper of Free Republic. You didn’t hit a nerve. Don’t think that your statements generate that kind of response. They dont. But if it is what you have to believe to feel validated — hey, you be you.
“Deep In The Gassy Stool” [DITGS]
Ahhhhhh, someone who believes in law fare. I am not dispensing medical advice, as you seem not to be able to delineate the difference. I am offering explanations as to biological mechanisms of work. Malpractice as a tort presumes a doctor patient relationship and a violation of the standard of care. As I do not maintain a doctor patient relationship and not dispensing individual advice, nice try, bonehead. Perhaps you should look up what a malpractice tort actually involves. Your statement of “anonymous” completely destroys your own argument.
I appreciate the others who are practicing without a license stating that Ivermectin and HCQ are cures and prevent progression to severe disease. This is actually something that would be actionable.
So let me ask you a question, are you just an idiot who lives in your parents basement, or do you actually believe the bull crap you write? Oh wait, let me make it simpler for you — are you just an idiot or a narcissist? You obviously dont know the first thing about what you write. And instead of defending your position, you throw stupid accusations that are patently false.
Go study a little bit and get back to me, you moron (and I mean that with all due respect)
Wow...smart and classy. 😉
Again....sure seem to have hit a defensive nerve.
Take care.
You are spending entirely too much time and effort defending yourself and trying to convince anonymous readers of your bona fides despite previously stating that “you know what you are” and have no need to convince me otherwise, yet you continue to argue with me.
Suffice to say this is very amusing. Suggest you stick answering phones and fetching coffee for your employer.
Have to get up early tomorrow so I’m going to turn in now. Good-night, Your Flatulence.
How would that be possible?
In between working months straight and 20 hour and 30 hour shifts, he's had a chance to pick up ANOTHER "board certification" in the last few months:
gas_dr [December 18, 2020]: "Already had it. Did fine. Critical care physician for 20 years. Triple boarded with academic rank. And you?"
https://freerepublic.com/focus/news/3916911/posts?page=50#50
WONDER gas_dr [April 20, 2021]:
"Clearly you missed it. I am a critical care anesthesiologist (intensivist) Boarded in four disciplines. Apparently Kirk won’t tell us WHAT he or she studies, let alone the pedigree. Thank you for asking."
https://freerepublic.com/focus/chat/3952418/posts?page=29#29
He's AMAZING!!!
Why do I smell the pine trees of the Hurtgen Forest? ;-)
Boarded in four disciplines.
Yeah, sounds legit.🤪
I think you might be right. I know there is also a potential link b/w some cancers (and maybe many) to viruses. We could be researching tech that could one day greatly reduce the cancer killer. Now if we could only crack the heart disease issue for good.
Disguise the pills as veterinary medicine or dirty, old world remedies, and the new age cult freaks might go for them. Or simply let them continue striving towards living in mud huts.
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