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To: Svartalfiar
“And how do you tell the body to stop producing its fake virus once your immune system is trained on that spike protein?”

mRNA has a short half-life (average half-life of mRNA has been shown in some studies to be ~4.8 minutes). Once you've been injected the mRNA encoding the spike protein will be taken up into cells (probably by endocytosis), and then rapidly translated into copies of the spike protein. In this manner, the adenovirus-mediated vaccines and the mRNA vaccines are doing essentially the same thing - providing a nucleic acid blueprint for making the spike protein. The adenovirus (a DNA virus) likely lasts a little longer (these are non-replicative adenoviruses that can't make more of themselves), and has a DNA blueprint for making the mRNA that will then get translated into the spike protein. So it's essentially doing the same thing as the mRNA vaccines, but is one step further back in the process.

Anyway, one of the limitations of gene therapy has been the inability to get the corrective gene sequences to last. This can be overcome with some viruses (HIV-derived vectors, retroviruses, AAV), but remains a big limitation. That said - it's not a worry that the Covid vaccine mRNA is going to hang out and make spike protein for a long time.

That said, the antibodies that are made could, theoretically, have some cross reactivity to human proteins and thus cause some unanticipated autoimmune phenomena. This is a risk with any vaccine.

56 posted on 04/06/2021 12:02:14 PM PDT by neverevergiveup
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To: neverevergiveup

This can be overcome with some viruses (HIV-derived vectors, retroviruses, AAV),

which use reverse transcriptase, right?


70 posted on 04/06/2021 12:48:46 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: neverevergiveup
In this manner, the adenovirus-mediated vaccines and the mRNA vaccines are doing essentially the same thing - providing a nucleic acid blueprint for making the spike protein.

Yes, I know that JnJ isn't a normal vaccine either - it's the same as the other two, just different carriers.


Anyway, one of the limitations of gene therapy has been the inability to get the corrective gene sequences to last. This can be overcome with some viruses (HIV-derived vectors, retroviruses, AAV), but remains a big limitation. That said - it's not a worry that the Covid vaccine mRNA is going to hang out and make spike protein for a long time.

Probably not, but there's plenty of other issues, plus, statistically, there will be some cells that your body takes a long time to change back to normal mRNA instructions. I'll just re-post what I wrote to someone else:
Yes, but my point is that this is where there's tons of potential for confusion - your body might recognize those fake virus cells as a part of your body, and decide the spike protein is ok. Or perhaps recognize the other parts (not just the spike) of that cell as an invader - parts that are shared by other things inside you that you don't want to be killed off.
But why would the body stop producing them? Unless some other mRNA is sent to the cells, won't they keep producing the fake virus nonstop? Sure, eventually your body will reprogram those cells back to what it actually needs, but not every fake virus producer may get changed for a long while. And what happens if your body detects that certain cells are creating the virus it's defending against? Possibly attack every other cell that produces stuff?
136 posted on 04/06/2021 9:39:39 PM PDT by Svartalfiar
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