Posted on 03/12/2021 3:11:53 PM PST by ConservativeMind
In mice genetically predisposed to glaucoma, vitamin B3 added to drinking water is effective at preventing the disease, a research team reports in the journal Science.
The vitamin administration was surprisingly effective, eliminating the vast majority of age-related molecular changes and providing a remarkably robust protection against glaucoma. It offers promise for developing inexpensive and safe treatments for glaucoma patients.
Conducting a variety of genomic, metabolic, neurobiological and other tests in mice susceptible to inherited glaucoma, compared to control mice, the researchers discovered that NAD, a molecule vital to energy metabolism in neurons and other cells, declines with age.
The decrease in NAD levels reduces the reliability of neurons' energy metabolism, especially under stress such as increased intraocular pressure. "Like taking that big hill on your old bike, some things are going to fail more often," John says. "The amount of failure will increase over time, resulting in more damage and disease progression."
In essence, the treatments of vitamin B3 (nicotinamide, an amide form of vitamin B3, also called niacinamide) boosted the metabolic reliability of aging retinal ganglion cells, keeping them healthier for longer. "Because these cells are still healthy, and still metabolically robust," says JAX Postdoctoral Associate Pete Williams, first author of the study, "even when high intraocular pressure turns on, they better resist damaging processes."
John says that the team is pursuing clinical partnerships to begin the process of testing the effectiveness of vitamin B3 treatment in glaucoma patients. They are also exploring potential applications for the treatment in other diseases involving neurodegeneration.
(Excerpt) Read more at sciencedaily.com ...
Some of tgem give you a flush, but it’s not uncomfortable.
“There are multiple forms of nicotinamide or niacinamide available at stores.”
I get mine in tobacco.š
We’ve started applying eyedrops of formulated Lanosterol and N-Acetylcarnosine (NAC) combination to our 12 1/2-year-old pup. It’s available over the counter or online at Amazon. It’s been about a week now, and we can see a difference in the glaucoma. It’s lumpier with perhaps some clearing in some areas like it’s breaking up. I understand people can use this same formula.
Great news for mice.
Are the no flush forms of niacin as effective as the flush kinds of niacin?
Nicotinamide (Nicotinic acid)(flush causing) and Niacinamide have very different effects in the body.
No-flush niacin doesn’t contain either nicotinic acid or nicotinamide. Instead, it contains inositol hexaniacinate. In theory, the body should slowly convert this into nicotinic acid. In reality, it doesn’t. An excellent study by researchers at the University of Washington School of Medicine showed that taking no-flush niacin generates virtually no free nicotinic acid, and has little or no effect on HDL.
Bttt
I love niacin.
It’s the only vitamin that alerts you that it’s working.
A post just down from yours may have some insight.
My wife and I take nicotinamide riboside, one of several downstream metabolites.
Thank you for that.
Now you’re scaring me!
I just took some B-6.
Decades ago, a co-worker asked me what to take for kidney stones. I recommended 50mg of B6 with Magnesium. He decided to double it. The next morning, he came to me after having nightmares all night. I recommend taking it in the morning. And don't overdo it. Too much B6 for too long can cause intense fatigue.
yea. I take 500 mg each of NR and NMN. Both convert to NAD along slightly different pathways. I throw in a bit of B3 because it also converts to NAD. I also take TMG because of methelation issues. As well, I take apiginen because it makes the NR & NMN more effective.
I don’t know if these are ideal doses/combinations.
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