Posted on 12/14/2020 10:57:30 AM PST by ConservativeMind
Prostatic hyperplasia, characterized by progressive hyperplasia of glandular and stromal tissues, is the most common proliferative abnormality of the prostate in aging men. Mangosteen pericarp powder (MPP) has abundant xanthones which can be antioxidant, anti-inflammatory, and antiproliferative agents. Therefore, the purpose of this study was to research whether MPP supplementation can affect the progression of prostatic hyperplasia. Our findings first demonstrated that MPP consumption significantly decreased the prostate weight, serum testosterone and dihydrotestosterone concentrations, protein expression of proliferating cell nuclear antigen, and malondialdehyde levels and ameliorated mitochondrial function in prostatic tissues. These results suggest that MPP supplementation could be used to attenuate the progression of prostatic hyperplasia.
MPP supplementation significantly decreased the percentages of prostate weight/BW in both the PL and PH groups by 18.9%, and the percentages of liver weight/BW significantly decreased by 26.4% and 34.2%, respectively
(Excerpt) Read more at nature.com ...
Mangosteen pericarp (its purple skin) appears to reduce inflammation and possibly helps reverse raw weight (our prostates basically get inflamed and stop killing off older prostate cells, causing a double net weight gain).
The powder is not tasty, but can be doctored up in drinks. It is available online as a bulk-type powder.
Note that they don’t exactly say how much powder was used.
And now for something completely different...
Regular congestion of organisms will ultimately result in regular defections.
Good news!
For old rats.......................
Mangosteen pericarp..... I think that was on the menu at the Chinese restaurant...............
Mangosteen pericarp components alleviate progression of prostatic hyperplasia and mitochondrial dysfunction in rats (BPH reduction)
You know, I was just thinking about that this morning. I came to the same conclusion. Over cereal and a banana. Ain’t it a small world?
Yea!!
Another Monty Python fan. Nudge, nudge, wink, wink. Say no more, say no more.
Interesting
Looks like it’s from China. Can it be trusted?
Also from Thailand
If you are referring to the research
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan
“Note that they don’t exactly say how much powder was used.”
Chemicals and reagents
Dried mangosteen pericarp, containing 4.6% xanthones, was purchased from First Canned Food (Thailand). Dried mangosteen pericarp was ground and sifted through a stainless steel sieve (80 mesh). Dimethyl sulfoxide (DMSO) and 3,2′-dimethyl-4-aminobiphenyl (DMAB) were purchased from Sigma-Aldrich (St. Louis, MO, USA). The dihydrotestosterone (DHT) enzyme-linked immunosorbent assay (ELISA) kit (IB59116) was purchased from Immuno-Biological Laboratories (IBL-America, USA).
Animals and experimental procedures
Five-week-old male F344 rats (n = 24) were purchased from the National Laboratory Animal Center (Taiwan). Animals were housed in an air-conditioned room maintained at 23 ± 2 °C with a relative humidity of 50%~60% and an alternating 12-h light/dark cycle. After 1 week of adaptation, all rats were randomly divided into four groups, including a control group (C), prostatic hyperplasia-induced group (P), prostatic hyperplasia-induced with low-dose MPP group (PL), and prostatic hyperplasia-induced with high-dose MPP group (PH), before the experiment began. The C group was given weekly intraperitoneal (IP) injections of DMSO for 10 weeks, and simultaneously fed a normal diet (AIN 93 G) for 24 weeks.
The P, PL, and PH groups were given weekly IP injections of DMAB dissolved in DMSO (25 mg/kg BW) for 10 weeks and simultaneously fed an HFD (50.9% of total kcal from fat) for 24 weeks. The PL and PH groups were separately supplemented with 2.5% and 5% (w/w) MPP in the HFD (Supplementary Table 1). MPP was rich in 68% (w/w) dietary fiber. In order to avoid differences in fiber contents among the diets, the cellulose weight of the treatment diets was respectively adjusted to 34 and 17 g/kg of diet in the PL and PH groups (Supplementary Table 1).
Each group contained six rats. Rats in each group were respectively provided with the experimental diet and water ad libitum. After being anesthetized with isoflurane gas, blood samples were collected from the tail vein for analysis of serum biochemical parameters at the beginning of the experiment. After 24 weeks of feeding, animals were anesthetized and sacrificed, blood and prostate samples were obtained for further analysis. All animal experimental procedures complied with published guidelines41,42 and were approved by the Institutional Animal Care and Use Committee of Taipei Medical University (Taipei, Taiwan; IACUC approval no: LAC-2017-0125).
“blood samples were collected from the tail vein for analysis of serum biochemical parameters at the beginning of the experiment. “
No comments about giving a rat’s ass!
THis post has nothing to do with this topic...but in looking at kidney stone issues I had no idea that an ole time remedy was corn silk.
It can actually help urinary issues including UTI issues
You can buy dried Corn Silk on Amazon and Etsy. Or buy the pills.
Per Healthline
May Not Be Right for Everyone
Very few adverse health effects have been reported from consuming mangosteen in its whole form, and it’s likely safe for most people.
However, more concentrated forms — like supplements, juices, or powders — are not 100% risk-free.
Early research suggests that xanthones found in herbal supplements may slow the process of blood clotting (29Trusted Source).
Because mangosteen is a rich source of xanthones, it may be a good idea to avoid concentrated sources of it if you have a blood clotting condition or are taking blood‒thinning medications.
Research to determine whether mangosteen supplements are safe for pregnant or breastfeeding women is currently insufficient, so it’s probably best to avoid it during these life stages.
Always consult your doctor or other qualified health professional before making significant changes to your diet or taking a new nutritional supplement.
SUMMARY
Mangosteen is likely safe for most people but may increase your risk of bleeding. Consult your healthcare provider before taking a new supplement or changing your diet drastically.
The problem here is that mangosteen is a banned fruit in the USA. Mangosteen is a delicious tropical fruit.
There are only 2 fruits in Malaysia that are strictly not allowed into Hotels - the durian because of its strong smell and the mangosteen because the pulp leaves a permanent stain.
The durian smells like open sewer or vomit. I can’t even stand walking by the street stands that sell it the smell is so bad.
“The problem here is that mangosteen is a banned fruit in the USA. Mangosteen is a delicious tropical fruit.”
Not banned since 2007. However it now must be radiated for import to kill any fruit flies, which is why it was banned originally.
I grew up with parents who were born on farms in the early 1900’s and they taught me many of the Indian remedies. That’s how I was raised.
Corn silk is a kidney cleanser, but we smoked more of it than we ate.
Dandelion was always the most important spring tonic, energizer, liver cleanse and we ate lots of it. The joke was always that the biggest plants were the ones that got the most manure on them.
Mangosteen has been used to treat skin infections and diarrhea. Recent scientific studies suggest that mangosteen possesses strong antioxidant, anti-cancer, anti-inflammatory, anti-allergic, anti-microbial, and anti-malarial properties (Gutierrez-Orozco and Failla 2013)
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