Posted on 11/30/2020 3:36:43 PM PST by SeekAndFind
The recent serious outbreak of Covid19 has affected (November 13, 2020) 53,796,098 people worldwide, resulting in 37,555,669 recovered, 1,310,250 deaths (Figure 1), and a large number of open cases. It has required urgent medical treatments for numerous patients. No clinically active vaccines or antiviral agents are available for Covid19. According to several studies, Chloroquine (CQ) and Hydroxychloroquine (HCQ) have shown promises as Covid19 antiviral especially when administered with Azithromycin (AZM).
However, there is significant controversy. Many countries are limiting the use of CQ/HCQ, while others are accepting this therapeutical option (Figure 2). The work [1] is addressing the open question if Chloroquine (CQ) and Hydroxychloroquine (HCQ) are helpful in Covid19 infection by analyzing the latest published literature on the subject while applying the scientific method.
Both papers in favor, or against, this therapeutical option are reviewed [1]. Bias by a conflict of interest is also taken into account. The rationale behind this use is clear. CQ/HCQ is effective against Covid19 in-vitro and in-vivo laboratory studies. Therapy in Covid19 infected patients with CQ/HCQ is supported by evidence of trials and field experiences from multiple sources. The relevant works are reviewed. The presence or absence of conflict of interest is weighed against the conclusions.
CQ/HCQ has been used with success in mild cases or medium severity cases. No randomized controlled trial has however been conducted to support the safety and efficacy of CQ/HCQ and AZM for Covid19.
Prophylaxis with CQ/HCQ is more controversial, but generally not having side effects, and supported by pre-clinical studies. The mechanism of action against Covid19 is unclear. More research is needed to understand the mechanisms of actions CQ/HCQ have against Covid19 infection, and this requires investigations with nanoscale imaging of viral infection of host cells.
Most of the published works indicate CQ/HCQ is likely effective against Covid19 infection, almost 100% in prophylaxis and mild to medium severity cases, and 60% in late infection cases.
The percentage of positive works is larger if works conducted under a probable conflict of interest are excluded from the list. The result is consistent with the updated analysis provided in [2], [3], that suggests high efficacy of CQ/HCQ in early treatments and lower efficacy and controversial results only for late treatment. Statistically, 100% of early treatment studies are positive, late treatment studies are mixed with 70% positive effects, 78% of pre-exposure prophylaxis studies are positive, and 100% of post-exposure prophylaxis studies also report positive effects [2], [3].
### References
[1] Boretti, A., Banik, B., and Castelletto S., 2020. Mechanism of action of Chloroquine/Hydroxychloroquine for Covid19 infection, Coronaviruses.
For more information on the research, please visit: https://www.eurekaselect.com/187910/article Authors:
Alberto Boretti1,*, Bimal K. Banik1, Stefania Castelletto2
1Prince Mohammad Bin Fahd University, ?Al-Khobar 31952, Saudi Arabia; 2RMIT University, Bundoora 3083 VIC, Australia
Ping as per your request
HQC has s was too cheap and not a single one of Biden’s pals will make a dime off of it
No one has to die, and this would keep hospital admissions to a minimum. Not to mention use as a prophylactic would nearly eliminate all these so called “cases”
This is what WE were saying 6 months ago. Heard it from lots of practicing physicians.
No kidding.
If you wait until someone is on death’s door to treat them, the damage has been done.
HCQ can affect the virus, but it cannot repair damage done to compromised organs.
Been following the c19study since the beginning.
Early HCQ results are very impressive.
BUMP!
And thank you for the post and ping!
Hydroxychloroquine
Mechanism of Action of HCQ - instructive video by Mobeen Syed, MD:
https://www.youtube.com/watch?v=MPCInuZjYUs
Famotidine
Mechanism of action of Famotidine - instructive video by Mobeen Syed, MD:
https://www.youtube.com/watch?v=TtN0gwP16cc
Ivermectin
mechanism of action of Ivermectin - instructive video by Mobeen Syed, MD:
https://www.youtube.com/watch?v=rFE3XE68Wfw
HCQ with a regimen of Zinc, Azithromycin, Vitamin D3 is very effective if used when first diagnosed. In the latter stage of the disease progression when critical care in a hospital is needed it is not that effective.
Ivermectin instead of HCQ also works. However, it is also effective in later progression of the disease where HCQ is not.
The use of HCQ and Ivermectin is quite legal for a physician to use as “off label” use of a prior approved drug. As it has become political our doctors hands have become tied.
I am 72 and considered high risk. If I become ill my physician will probably not give me the treatment I need after original diagnosis. He has protocols that are insane and he will not and can not violate. His early treatment will be little. If I become greatly ill I will be admitted to hospital and at great expense may live or may die. With rational treatment I would not need to be admitted.
If I am diagnosed with Covid-19 I will treat myself. I know the protocols. I am a clinical pharmacist now two years retired.
I forgot to add this about Covid 19 rate of infections in third world tropical nations. It is low, much lower than the USA and Europe. Their medical facilities and care is far below ours and Europe. Why is their infection rate lower?
The answer is very simple. The Answer Is Malaria. These areas are endemic with Malaria. Everyone take HCQ as prophylaxis for Malaaria. I also did when working in Nigeria for a couple of years. The HCQ did not kill me nor anyone else on my drilling rig. Nor did but very few catch Malaria.
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