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The coronavirus is mutating — does it matter?
Nature ^ | 08 September 2020 | Ewen Calloway

Posted on 09/08/2020 7:26:14 AM PDT by BenLurkin

Soon after SARS-CoV-2 was detected in China, researchers began analysing viral samples and posting the genetic codes online. Mutations — most of them single-letter alterations between viruses from different people — allowed researchers to track the spread by linking closely related viruses, and to estimate when SARS-CoV-2 started infecting humans.

Viruses that encode their genome in RNA, such as SARS-CoV-2, HIV and influenza, tend to pick up mutations quickly as they are copied inside their hosts, because enzymes that copy RNA are prone to making errors. After the severe acute respiratory syndrome (SARS) virus began circulating in humans, for instance, it developed a kind of mutation called a deletion that might have slowed its spread4.

But sequencing data suggest that coronaviruses change more slowly than most other RNA viruses, probably because of a ‘proofreading’ enzyme that corrects potentially fatal copying mistakes. A typical SARS-CoV-2 virus accumulates only two single-letter mutations per month in its genome — a rate of change about half that of influenza and one-quarter that of HIV, says Emma Hodcroft, a molecular epidemiologist at the University of Basel, Switzerland.

Other genome data have emphasized this stability — more than 90,000 isolates have been sequenced and made public... Two SARS-CoV-2 viruses collected from anywhere in the world differ by an average of just 10 RNA letters out of 29,903...

Many mutations will have no consequence for the virus’s ability to spread or cause disease, because they do not alter the shape of a protein, whereas those mutations that do change proteins are more likely to harm the virus than improve it (see ‘A catalogue of coronavirus mutations’). “It’s much easier to break something than it is to fix it,” says Hodcroft, who is part of Nextstrain, an effort to analyse SARS-CoV-2 genomes in real time.

(Excerpt) Read more at nature.com ...


TOPICS: Health/Medicine
KEYWORDS: ccpvirus; covid19; dsj03; mutationing; mutations; viri; virus; whuwho; wuhanflu
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To: BenLurkin

All viruses mutate. Most tend to mutate weaker not stronger.


21 posted on 09/08/2020 9:09:44 AM PDT by Georgia Girl 2 (The only purpose of a pistol is to fight your way back to the rifle you should never have dropped)
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To: webheart

Thank you, Dr. Fauci.


22 posted on 09/08/2020 9:37:31 AM PDT by miserare ( Respect for life--life of all kinds-- is the first principle of civilization.~~A. Schweitzer.)
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To: Tilted Irish Kilt
... The blessing of mutations is that the mutations tend to slow and self-limit the virus, that is that they are self-detrimental . The mutations change the efficacy of the virus, and in fact, generally weaken it.

And that should work in the long run as long as China doesn't keep 'accidentally' keep re-releasing the original...

(Example: China and India have a border dispute and 7 weeks later cases skyrocket in India. That kind of crap - not saying that happened...)

23 posted on 09/08/2020 9:41:38 AM PDT by GOPJ (Black NFL players build mansions in white world to escape blacks - then kneel from guilt.)
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To: GOPJ
GOPJ :" (Example: China and India have a border dispute and 7 weeks later cases skyrocket in India. That kind of crap - not saying that happened...) "

I understand it's a possibility, or pure conjecture, on your part.
But think about it for a minute ...
One of the side-effects of covid19 is arterial cardio infection as well as lung scaring; with the latter affecting the ability to oxygenate the blood system.
One of the symptoms of covid is clinically known as dyspnea, a shortness of breath which can occur between 4 -10 days after infection.
It affects your ability to function, work, think, and can last for several months later; some athletes are noticing chronic shortness of breath after recovery.
The contentious border between China and India is at high altitudes, where in many cases the ability to breathe in high altitudes restricts even the ability to walk.
As I understand it, India uses natives in the area who have a biological ability to function in low oxygen environment.
Such a use of covid19 as a bio-warfare agent is not outside the realm of possibility.
Think of it as "Occam's Razor ".

24 posted on 09/08/2020 10:08:28 AM PDT by Tilted Irish Kilt
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To: Tilted Irish Kilt

https://www.aljazeera.com/news/2020/09/india-added-million-covid-19-cases-week-200901091636897.html

India added half a million COVID-19 cases in one week: WHO

India reported the most new cases worldwide in the past week, pushing global tally by 1 percent, the UN agency says.


25 posted on 09/08/2020 10:14:15 AM PDT by GOPJ (Black NFL players build mansions in white world to escape blacks - then kneel from guilt.)
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To: Tilted Irish Kilt
"... reported the most new cases worldwide in the past week, pushing global tally by 1 percent, the UN agency says. 01 Sep 2020 10:38 GMT"
26 posted on 09/08/2020 10:16:06 AM PDT by GOPJ (Black NFL players build mansions in white world to escape blacks - then kneel from guilt.)
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To: GOPJ
GOPJ :" "... reported the most new cases worldwide in the past week, pushing global tally by 1 percent, the UN agency.
India added half a million COVID-19 cases in one week: WHO "

Right, that's possibly true .
Do you trust WHO ?.. I don't, not since the Wuhan outbreak.
Do you trust the UN ? .. I don't; I believe the agency has become partisan and anti-American .
Nevertheless, Yes, I can believe that covid is spreading there, but WHO statistical modeling, from the very beginning, was off 10 fold.
Also, while the evidence of covid explodes there, don't forget that a large number (I believe 90%)are asymptomatic, as well as 'false positives'.

27 posted on 09/08/2020 10:51:51 AM PDT by Tilted Irish Kilt
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To: walkingdead
What they do not want you to know is that there is always a slight mistake in replication...

That's exactly what the article says.

28 posted on 09/08/2020 12:07:20 PM PDT by BenLurkin (The above is not a statement of fact. It is either opinion or satire. Or both.)
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To: politicianslie

Reference bump!

Capers (raw) or processed have the highest levels of Quercetin - I always use capers in my salads and omelettes (best with Brie, bacon, capers and avocado ;-).

Pre-CV-19.

My Centrum Silver (Men 50+ , different than just Silver) has high levels of Zinc, and other goodies that I might miss in my diet Ds, Bs, etc..

Still here, so that’s a good thing, right?

Generally how’d you get the HCQ? Please do tell or hint?


29 posted on 09/08/2020 4:01:42 PM PDT by Tunehead54 (Nothing funny here ;-)
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