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Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2
MedicalExpress ^ | 08/04/2020 | La Jolla Institute for Immunology

Posted on 08/04/2020 4:31:36 PM PDT by BenLurkin

The new work builds on a recent Cell paper... which showed that 40 to 60 percent of people never exposed to SARS-CoV-2 had T cells that reacted to the virus. Their immune systems recognized fragments of the virus it had never seen before. This finding turned out to be a global phenomenon and was reported in people from the Netherlands, Germany, the United Kingdom and Singapore.

Scientists wondered if these T cells came from people who had previously been exposed to common cold coronaviruses—...

For the new study, the researchers relied on a set of samples collected from study participants who had never been exposed to SARS-CoV-2. They defined the exact sites of the virus that are responsible for the cross-reactive T cell response. Their analysis showed that unexposed individuals can produce a range of memory T cells that are equally reactive against SARS-CoV-2 and four types of common cold coronaviruses.

Looking closer, the researchers found that while some cross-reactive T cells targeted the SARS-CoV-2's spike protein, the region of the virus that recognizes and binds to human cells, pre-existing immune memory was also directed to other SARS-CoV-2 proteins. This finding is relevant, Sette explains, since most vaccine candidates target mostly the spike protein. These findings suggest the hypothesis that inclusion of additional SARS-CoV-2 targets might enhance the potential to take advantage of this cross reactivity and could further enhance vaccine potency.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: chinavirus; chinavirusinfo; commoncold; coronaviruses; germany; immunesystem; netherlands; sarscov2; singapore; unitedkingdom

1 posted on 08/04/2020 4:31:36 PM PDT by BenLurkin
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To: BenLurkin

This also explains why children seem to have very mild cases. Most children pass the common cold around constantly.


2 posted on 08/04/2020 4:58:25 PM PDT by Valpal1
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To: BenLurkin
Does that mean that all this mask wearing and distancing is weakening us for the next round?

3 posted on 08/04/2020 4:59:30 PM PDT by BitWielder1 (I'd rather have Unequal Wealth than Equal Poverty.)
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To: BenLurkin

individuals can produce a range of memory T cells that are equally reactive against SARS-CoV-2 and four types of common cold coronaviruses.

“cold coronaviruses”

These heretics should be burned at the stake


4 posted on 08/04/2020 5:10:21 PM PDT by Vendome (I've Gotta Be Me https://youtu.be/wH-pk2vZG2M)
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To: BenLurkin

Wonder if my years being employed in a preschool and all those germs I was exposed to has helped me to ward this virus off?


5 posted on 08/04/2020 5:11:55 PM PDT by grayboots
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To: BitWielder1

Yes, so it seems. Fortunately, the masks don’t really seem to protect anyone from anything (except bacterial infection, but not even that if you’re wearing the same mask day after day or even all day), so I guess if people are out, they’re still getting exposure.

Interestingly, many of the people in NYC who died were not the people who were out and about, but people who were isolated with family members in their apartments in the projects, not being exposed to strangers but rebreathing the same old air with its concentration of virus. I think you could argue that exposure to numerous others could actually boost immunity.

The human race would never have made it if our bodies didn’t have these ingenious systems of building immunities.


6 posted on 08/04/2020 5:15:00 PM PDT by livius
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To: grayboots

That would also explain why most Walmart cashiers and employees have not been laid low from this virus in spite of being at a greater risk of exposure than the average American who’s been hiding in their homes and only venturing out with a mask.


7 posted on 08/04/2020 5:42:53 PM PDT by punknpuss
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To: BenLurkin

This is the last thing vaccine Fauci wants us to know about.


8 posted on 08/04/2020 6:00:42 PM PDT by FreeReign
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To: BitWielder1
Yes.

Although certain people will have a conniption fit if you tell them that.

Polio is a virus that has been around for a long time but for thousands of years you caught it while you were still a nursing baby. Your mother passed along her antibodies to you and you had a very mild case that allowed you to produce your own antibodies. You were then immune.

But then we began to live cleaner lives. Cleaner water, better sanitation especially around babies. And you did not catch it as a baby but when you were older. You no longer were partly protected by your mother's antibodies. So in a small number of cases you ended up paralyzed or dead.

Catching viruses is a natural thing, the more things we have a mild case of the more things our body has built defenses against.

9 posted on 08/04/2020 9:00:17 PM PDT by Harmless Teddy Bear (And lead us not into hysteria, but deliver us from the handwashers. Amen!)
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To: BitWielder1

Yeah - I think the phrase, “What doesn’t kill you, makes you stronger” was invented to describe our immune systems...the body needs to run into a lot of bugs to build the best defense systems.


10 posted on 08/05/2020 3:41:52 AM PDT by trebb (Don't howl about illegal leeches, or Trump in general, while not donating to FR - it's hypocritical.)
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To: Valpal1

I’m one of those people who get colds super easy. Someone just walks by me with a cold and...bam! I’m sick. Just got over one. Maybe that explains why no Rona for me. I have just been living life...Vegas twice, once by plane...just got back from Arkansas/Oklahoma/Kansas flew there....the Indian casino in Solvang twice...and am leaving for Vegas again tomorrow. Only thing I’ve done any different is wear a mask where required and put a bottle of Purell in my car.


11 posted on 08/05/2020 5:13:40 AM PDT by sheana
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To: sheana

I was a Montessori teacher for many years and haven’t had a cold or anything else viral for what seems like a decade. Everyone in my family gets a cold, it passes me by. I figure I was exposed so many times from working with young children that my immune system is still highly sensitized to cold viruses.

I don’t even have purell in my car because it’s too hot right now, no wipes either, although I plan to get some when I shop later because we are taking a car trip and need to wipe our hands after snacking, lol.

I made some hand knit easy breath masks that only stop dirty looks from the Karens and violent hypochondriacs.

I do think this virus is very dangerous to certain risk groups, but everything is dangerous for them, but so is shutting down the economy.

The dems are politically insane.


12 posted on 08/05/2020 10:43:13 AM PDT by Valpal1
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To: Valpal1

I hate the masks. Only wear them when there is no way around it.


13 posted on 08/05/2020 5:03:13 PM PDT by sheana
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