Posted on 05/17/2020 7:28:29 PM PDT by edwinland
Purpose
Infection with COVID-19 potentially can result in severe outcomes and death from “cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.
Methods
Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2 g of PO or IV glutathione was used in both patients and improved their dyspnea within 1 h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms.
Conclusion
Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NF-κB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia.
(Excerpt) Read more at sciencedirect.com ...
Do the glutathione precursors (N-acetyl-cysteine or NAC) have any prophylactic effect?
Interesting that this was just a couple days ago on MedCram.
I’ve been taking copious amounts of nac when the covid 19 started..it’s very anti inflammatory for the lungs.
Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine), May 11, 2020.
Dr Louis P Coates
May 14 at 11:18 PM ·
Coronavirus Update 5/15/2020 - BTHO COVID-19
So today at the time of this writing there are 27,246 new cases today with 1715 deaths. Today’s mortality rate is at 6.29%. We also have 16,240 in critical condition still high so the fatality numbers will likely stay high a while longer. I was thinking the critical care number would start coming down soon. Today the overall mortality rate rose a little to 5.92%.
We also have now had 318,027 people recovered from this virus and should now have some degree of immunity from this horrific disease.
Locally, in Texas cases are relatively flat. We had 1482 new cases and 64 new deaths with a steady mortality rate of 2.8%.
Because antibody testing is being added to the numbers we are monitoring active cases. So we have 18,645 barely up from 18,355 active cases in Texas. The number of active cases is slightly increasing. In addition we have 24,600 recovered now. So active cases are very stable.
We are still many times under both the number of hospital beds and ICU beds needed. Hospital beds currently needed 1,289 with 28,634 available, in addition 358 ICU beds are needed and 2,260 available. So yes we should be open as there is no way to completely get rid of the virus. We must learn to coexist with it. Do not live in fear but respect the virus and take necessary precautions.
Today in Dallas county with 236 new cases and 6 deaths. Harris county with 196 new cases and 5 new deaths. Collin county with 15 new cases and 1 new death. Denton county with 21 new cases and no new deaths. Tarrant county with 266 new cases and 5 new death. Brazos county with 14 new cases and no new deaths. Travis county with 57 new cases and 2 new deaths. Fort Bend county with 48 new cases and no new deaths. Also Bexar county with 34 new cases and one new death.
For the newbies we are predicting an overall fatality rate somewhere in the 0.3 to 0.7 range when we finally correct the denominator. The real question is just how much of the population is already infected 2%, 5%, 10% etc.
New study in Russia shows potential benefit for NAC
A new study by Russian medical researchers suggests that deficiency of endogenous glutathione could also be another influencing factor of the degree of susceptibility by individuals towards the SARS-CoV-coronavirus that causes the deadly COVID-19 disease. Glutathione is naturally made in the human body and it can be supplemented in the body via supplementation with NAC or N-Acetyl Cysteine as it is a precursor for Glutathione production in the body.
Deficiency of glutathione has already been demonstrated through past studies to be associated with a growing number of chronic diseases including diabetes. asthma, autoimmune disorders, heart and lung diseases. As a person ages, glutathione levels typically falls and men also tend to have lower glutathione levels than women as they age. All of those sound familiar as they should as they are all risk factors for Covid-19. In addition another correlation is more men 60% get infected than women.
Glutathione is also a potent anti-oxidant that has also demonstrated antiviral properties in past studies. Not only does it help with oxidative stress it also decreases inflammation while helping boost the functions of immune cells. Knowing that NAC is a precursor for glutathione it should help fix all of these issues.
“Furthermore the antiviral effect of glutathione is clearly non-specific, since GSH is known to inhibit replication of various types of viruses, and therefore there is reason to believe that glutathione is also active against the novel coronavirus infection. Our observations demonstrate that patients with moderate-to-severe COVID-19-infection have lower levels of glutathione, higher ROS levels, and greater ROS/GSH ratio than patients with a mild illness suggesting that coronavirus SARS-CoV-2 cannot actively replicate at higher levels of cellular glutathione, and a lower viral load is manifested by milder clinical symptoms. This makes glutathione a promising drug for etiological treatment of various viral infections.”
https://www.researchgate.net/publication/340917045_Endogenous_deficiency_of_glutathione_as_the_most_likely_cause_of_serious_manifestations_and_death_in_patients_with_the_novel_coronavirus_infection_COVID-19_a_hypothesis_based_on_literature_data_and_ow
https://www.thailandmedical.news/news/breaking-covid-19-research-russian-study-indicates-that-glutathione-deficiency-affects-covid-19-susceptibility,-nac-supplements-helps
Another hydroxychloroquine study which helps give some answers?
This is a preliminary report on a study at NYU. This study examines adding zinc to hydroxychloroquine and zithromax. The reason I mention it is because that is what we are doing in clinical practice but the zinc is missing from most of the other studies. Remember that HCQ is a zinc ionophore and it allows zinc to get inside the cell where it can inhibit replicase. This enzyme is what allows the virus to reproduce itself. So not enough zinc than it can’t work. Zinc is very important and is being left out of most of the studies but we are using it in clinical practice and seeing anecdotal results.
So in this study 411 patients given zinc along with the malaria medicine hydroxychloroquine and the antibiotic azithromycin for five days were 44% less likely to die and 50% more likely to be discharged home than a comparison group of 521 patients who didn’t get the zinc supplement. Thus, this shows you need the zinc to get the better results.
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1
In addition the NIH is starting a study of 2,000 patients with mild to moderate Coivd-19. This is a much needed study but unfortunately it appears to be HCQ/zithromax vs placebo. I don’t see where they are using zinc in this study either.
https://www.nih.gov/news-events/news-releases/nih-begins-clinical-trial-hydroxychloroquine-azithromycin-treat-covid-19
Here is a repost of the supplements we have discussed to have potential benefits.
Quercetin from 250mg up to 1g twice per day Remember this is a Zinc ionophore.
Vitamin D3 Take this for sure if you are deficient and I now recommend taking it as long as your values are not too high.
Sleep greater than 8 hours per night
CoQ10 100-300mg per day: a potent antioxidant that potentially helps balance oxidative stress, increase vasodilation, prevent clot formation and decrease vasoconstriction.
Zinc any amount is probably good but take what you can tolerate without making you feel bad up to 40mg. You do not want to be Zinc deficient as it is how many drugs like HCQ work.
Melatonin 1mg to 10mg at night. Take what you can tolerate and what helps you sleep without making you feel drugged or tired in the morning.
N-acetylcysteine (NAC) - 600mg twice per day shown to decrease severity of influenza, improve lung functions, antioxidant properties and help with mental disorders.
Vitamin C 250mg to 500mg twice per day. Effects debatable in oral form but IV did help in China. But is proven to strengthen immune system
Green Tea either drink some or 1 pill per day alternate zinc ionophore if you don’t have or don’t take Quercetin
As always the information and understanding of COVID-19 is changing rapidly. This information is for education purposes only and you should never make changes to your health without consulting your personal physician. Make a virtual appointment with your physician and discuss your health and the best possible treatment plan for you. It is also important to reiterate that there are no clinically evidence-based integrative prevention or treatment strategies for COVID-19 infection.
Let’s all keep praying for all that are ill with this virus in the world.
Gig’em!
A Study of N-acetylcysteine in Patients With COVID-19 Infection
Brief Summary
The study researchers think that a medication called N-acetylcysteine can help fight the COVID-19 virus by boosting a type of cell in your immune system that attacks infections. By helping your immune system fight the virus, the researchers think that the infection will get better, which could allow the patient to be moved out of the critical care unit or go off a ventilator, or prevent them from moving into a critical care unit or going on a ventilator. The US Food and Drug Administration (FDA) has approved N-acetylcysteine to treat the liver side effects resulting from an overdose of the anti-inflammatory medication Tylenol® (acetaminophen). N-acetylcysteine is also used to loosen the thick mucus in the lungs of people with cystic fibrosis or chronic obstructive pulmonary disease (COPD). This study is the first to test N-acetylcysteine in people with severe COVID-19 infections.
Was about to ping you, but see (shoulda known :) that you’re already here.
My liposomal VitC has glutathione and I also have ordered Liposomal Glutathione.
I am going to go offline for 24 hours and see if that will help my eye problem. Btw, Medcram has had a video taken down about zinc and HQC . his latest.
i still cant figure out how to view them on medcram’s site.
i think youtube is auto taking down anything that mentions HQC
Youtube is taking EVERYTHING that discusses the efficacy of HCQ protocol down :(
OANN did an excellent, hour long special, tonight of testimonies of docs, recovered patients...all who’ve used the HCQ protocol.
Hope your eye gets better.
Do you have any Colloidal Silver drops? Have family members who’ve used it for pink eye.
no, hadnt thought of that..just tried systane because I have dry eyes anyway and thought that might help...it didnt.
will look into that
edwinland wrote:
“Interesting case study.”
Yes it is.
Now I have to find who mentioned NAC before this; need to ping them to this thread...
A few years back when the H-1-N-1 flu made its rounds, I believe it was around 2009 some one on Free Republic, I believe it may have been a medical doctor suggested to take NAC which is short for N-Acetyl Cysteine and one shouldn’t have any problem with this particular flu and a flue shot would not do much better.
Needless to say it aroused my interest and I started to research NAC and found many beneficial properties, amongst it being a precursor to Glutathione (GSH) which is a tripeptide found in most of the tissues, especially in high concentrations in the liver, and plays an extremely important role in protecting hepatocytes, erythrocytes, and other cells against toxic injury and it declines as the human body ages.
Amongst other beneficial properties of NAC is that it is frequently used as an antidote if and when some one overdoses with acetaminophen and ends up in the emergency room; contained in such pain killers such as Ibuprofen, Advil, Motrin, Aleve etc. as it cleans out this poison, that should give you a hint of what NAC is capable of doing.
It also has been shown to be quite beneficial for people with COPD, in other words people with breathing problems and you will find many who swear by it. Another interesting item I came across was the suggestion to use about twice as much buffered ascorbic acid (vitamin C) as NAC. Not only is a large amount of buffered C good for the human body but it also will facilitate the disposal of any undesirable substances which NAC removed from the liver. Vitamin C also helps to reprocess glutathione by converting oxidized glutathione back to its active form. Linus Pauling who captured the Nobel Prize twice was a big proponent of Vitamin C and very rightfully so.
I have been taking it ever since I came across the information about NAC being a precursor to Glutathione and the many benefits associated with it and so far it has served me very well. For interests sake my daily intake along with many other nutrients and vitamins is about 2000 mg of NAC and about 5000 mg of buffered C.
And as an insurance not to end up with the latest virus you always can read up on BHT which will damage the majority of lipid covered viruses and by doing so will deactivate such viruses with the corona virus being one of them.
Thank you for this; I had seen a freeper mention NAC on some thread, and wasn’t sure which thread it was.
Yes, and also an earlier reply to this post has a very good discussion of NAC
BTTT!
I’ve been taking NAC for years. One reason I haven’t been worried about Covid-19.
do you suffer from eyestrain? if so, doc told me eyestrain from viewing computer too long was causing dry eyes- my eyes would sting, and feel like pressure in eyes- so bought some computer glasses- they really help with the eyestrain quite a lot- they filter out the blue waves or whatever that cause the strain i guess—
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