Posted on 04/30/2020 6:33:20 PM PDT by SeekAndFind
In an article published in Il Tempo, one of Italy’s leading independent newspapers (Britannica.com), Annalisa Chiusolo, a prominent pharmacology researcher, described the mechanism of action of SARS-CoV-2. By understanding this mechanism, it is possible to target and select the most effective drugs against COVID-19 with accuracy and precision. The coronavirus affects the ability of the hemoglobin to transport oxygen, creating the preconditions for lung complications, known to be associated with COVID-19: breathlessness, acute respiratory distress syndrome, and death.
Discovering the theory of viral replication is the first step of any verification. Science proceeds by refutation or confirmation. If this thesis were confirmed, many unknowns would be explained. For example, why COVID-19 affects more men, people with diabetes, fewer women in general, and even fewer pregnant women, very few children, and people with thalassemia. It would close the circle.
Image credit: www.sciencedirect.com
Why Does the Novel Coronavirus Strike Older People More?
It is projected that by 2053, China will become the oldest country in terms of population. This problem can be solved, but the most drastic measure is infecting people with the novel coronavirus. We’ve prepared some facts, and it’s up to you whether to believe them or not.
The virus needs porphyrins for its survival (probably for its replication), so it attacks the hemoglobin (the protein that carries oxygen in the blood), in particular, the OFR10 and OFR3 proteins attack the beta chain, and orph1ab subtracts the porphyrin. The concepts seem a bit abstruse for a layman, but simply speaking, this translates into less oxygen available to the body, with consequent accumulation of carbon dioxide. Thus, the lung cells enter into a state of distress and become the site of the cytokine storm – that is, an enormous immune response – responsible for the acute inflammation that characterizes COVID-19 pneumonia.
The value of hemoglobin in the blood can be an important parameter to assess the SARS- CoV-2 infection: in men, the average value of Hb (hemoglobin) is higher than in women. This would explain the higher incidence of COVID-19 pneumonia in men compared to women, the lower incidence, and the better prognosis in children and pregnant women, where Hb values are lower due to an increased need for iron, which makes less available the "nutrition" of the virus. In elderly or middle-aged patients with diabetes, pneumonia from COVID-19 has a higher incidence, therefore linked to increased Hb glycated in the blood, and therefore there is more "nourishment" for the virus.
The viral damage, therefore, is systemic, i.e., it affects the blood and is not confined to the lung alone. This would also explain the birth of healthy babies from COVID-19 positive mothers. Because in fetal Hb – stay with me, we will now use some technical concepts – two gamma chains replace the two beta chains, a difference is the presence of a residual serine, instead of a histidine present in the same position of the beta chain, probably responsible for the binding with viral proteins, which could mimic the action of 2,3bifosfoglycerate.
All this would explain the lower incidence and better course of the disease in infants, missing the main site of action of viral proteins, i.e., the beta chains of Hb. In short, in infants, the same concept of "nutrition" for the coronavirus is missing.
The same goes for a chronic pathology called Beta-thalassemia, where the "beta" chains of hemoglobin (the target of the virus) are deficient or even absent. This would demonstrate the lower incidence and better prognosis and course of the pathology in thalassaemic beta-thalassaemias, which in Italy are widespread in Mediterranean areas such as Puglia, Sicily, and Sardinia (particularly in the south) where there is a thalassaemia rate of 12% (alpha and beta). To confirm this theory, there is a scientific publication that has put in relation the subjects affected by beta-thalassaemia and COVID-19, in the data taken from PubMed: as of April 10, 2020, 11 cases of COVID-19 positive beta talassaemia were recorded in Northern Italy, where the rate of contagiousness is higher. Ten of them are affected by thalassaemia dependent on transfusion, the most severe form, only one by thalassaemia is not reliant on transfusion.
However, all patients who contracted the virus had comorbidities, very serious diseases: splenectomized, pulmonary hypertension, lymphoma, and chemotherapy. Despite this multi-pathological picture, there were no deaths, no cytokine storms, or severe SARS in the 11 subjects.
Earlier, Dr. Zelenko shared his detailed coronavirus treatment plan based on his own experience in treating COVID-19 patients.
A Detailed Coronavirus Treatment Plan from Dr. Zelenko
We received an exclusive letter from Dr. Vladimir Zelenko again, in which he told his story and shared his COVID-19 treatment plan in detail.
For example, the central mechanism of action of hydroxychloroquine, and its effectiveness in combating COVID-19, can now be fully explained and understood. What this mechanism consists of is immediately stated: the drug, by binding itself permanently with ferriprotoporphyrin (of the Hb group Eme), removes the substrate from the viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shield" from the virus, among the directors of infectious disease departments, specialists, primary care physicians, and general practitioners contacted during this research, many have admitted – under the subheading – to using the drug as a “prophylaxis”, i.e., to prevent contagion.
Healthcare professionals who are in close contact with infectious patients take the drug, Hydroxychloroquine in advance, precisely to decrease the likelihood of infection. For now, there is a recent publication, involving 211 people, to support this ”prophylactic” effect. It was published in the International Journal of Antimicrobial Agents, the official organ of the International Society of Antimicrobial Chemotherapy. Of 211 people exposed to COVID-19 positive individuals and prophylaxis with hydroxychloroquine, none were infected.
Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?
In the context of the ongoing global outbreak of coronavirus disease 2019 (COVID-19), management of exposure events is a concern. Long-term care hospi…
Finally, further confirmation of this hypothesis is provided by the data collected in the register of the SIR (Italian Society of Rheumatology). In order to evaluate the possible correlations between chronic patients and COVID-19 SIR interviewed 1,200 rheumatologists throughout Italy to collect statistics on contagions. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil/hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, and nobody is in intensive care, according to the data collected so far.
This is great news.
But I fear every other country in the world will have to use this treatment before the egos of the Fauci legion will be forced to offer it to Americans.
That fills in some blanks. Thank you.
In this article the theory is the virus is affecting the blood so that it doesn’t pick up oxygen and that has been seen in the hospitals where the ventilators are ineffective.
So here the theory is that hydroxychloroquine works separately, without zinc, to protect the blood from the virus. The other theory is that HCQ assists the zinc to kill the virus within cells.
Yesterdays article, “MEDIA LIED, PEOPLE DIED: Italian Study Finds INCREDIBLE Prophylaxis Results for Patients on Hydroxychloroquine” commenter JohnBovenmyer pointed this out and that comment is worth a read.
I stumbled across this but want to know what Clioquinol is. I started with a photo of an article so I don’t have a link.
Clioquinol {lodochlorhydroxyquin) to Treat and Terminate COVID-19. 3% Clioquinol Cream is Available Now.
Leslie C. Costello, PhD.
Department of Oncology and Diagnostic Sciences
University of Maryland School of Dentistry; and the
University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Md. 21201
Abstract: 3% Clioquinol Cream will likely terminate the COVID-19 virus infection, and possibly suppress its development; and it presents little or no adverse side effects. Clioquinol (iodochlorhydroxyquin) is a zinc ionophore that exhibits properties that are ideal for binding with zinc (ZnClioquinol). It also has zinc cytotoxic effects that will terminate the COVID-19 virus. It is more effective than chloroquine/hydroxychloroquine. There is no need to wait 1-2 years for the development of new medications.
I read your profile.
You need to add these to yer big gubbermint list:
Mandating toilets that use no more than 1 gallon per flush, why they didn’t flush well.
Banning incandescent light bulbs, so you get to buy expensive mercury filled CFL’s that don’t last as long if you turn them on and off often.
Banning DDT to save endangered birds, killing tens of thousands of humans from malaria.
And here’s the best of them all, the winner by virtue of how absurd it was, from the Obama stimulus package: millions of US tax dollars going to Africa in an effort to educate sub Saharan men on the proper use of a condom. I had 11 years to think about that one, and I’m still not sure how that stimulated the US economy.
Are you taking Plaquenil?
I have two friends who take it as a maintenance protocol, (one) for lupus and (the other) for RA.
I believe one of them may also be taking a low dose zinc, now.
Why would the thread get buried?
Too easy.
Most of that boodle never left the CONUS, so yeah, spent locally to (ahem) stimulate the economy!
The absurdity was that they thought of that as the excuse for cutting the check, and everybody bought it.
Because people post newer threads which get more responses.
It happens a lot.
He uses a lot of great analogies.
I’ve listened to a few of his interviews.
Okay....was making sure you didn’t mean ‘pulled’.
I’ll bump this thread, again, in the morning.
I took myself off of it about 15 years ago. Regret that now ; )
My rheumatologist was not happy.
Do you know how much zinc your friend takes?
bbb
How much further ahead of this virus would we be if PDJT had not followed Fauci and Birx advise.
How many "out of 65,000 chronic Lupus patients" mentioned in the article had these severe side effects?
Wouldn’t people who were on long term maintenance already when the virus hit be people whose doctors would have changed their medications to something else earlier if they had a reaction?
The 65000 people in the Italian article by definition would already have been screened before going on hydroxychloroquine.
This was fake news. The reporter for the article in Il Tempo got the facts completely wrong, and was corrected by the head of the Italian Society of Rheumatology:
We are sorry to inform you that the journalist has misrepresented what we have communicated to him and that there is no investigation into patients using hydroxychloroquine in Italy.In the Register of the Italian Society of Rheumatology (CONTROL-19) 150 patients with rheumatological pathologies are included and of these 20 took hydroxychloroquine.
Unfortunately, we are receiving many similar risks, as the publication of the aforementioned article has created much confusion.
Trusting that we have clarified the misunderstanding, we send our best regards,
Luigi Sinigaglia - President of SIR
Fake news. See post #57.
They are in a comment by "Will Bailey" below the Il Tempo.it article that started this mess. They are in Italian.
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