Posted on 04/23/2020 7:15:35 AM PDT by SeekAndFind
The results of clinical trials are making their way to publication showing hydroxychloroquine to be effective in many, although possibly not all, situations. The American media is silent on these studies.
The results of clinical trials are making their way to publication showing hydroxychloroquine to be effective in many, although possibly not all, situations. The American media is silent on these studies. Instead, the American media headline a non-experimental and biased study showing the drug to be ineffective and, even, a cause of death.
The non-experimental study concerns a large number of COVID-19 patients (sample size 368) at Veterans Administration medical centers. These were older men, many with comorbidities. The study is non-experimental because patients weren't randomly assigned to control and experimental groups. Instead, the sicker patients tended to be administered hydroxychloroquine. It is recognized by the authors of this study that the correlation of severity with prescription imparts bias into the sample. The authors reduce (but do not eliminate) this bias through "propensity score adjustment."
LINK TO VA STUDY: https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1.full.pdf
When asked about this study on Tuesday evening at the President's daily briefing on the coronavirus pandemic, Stephan Hahn, Commissioner of the FDA, pointed out that the study was retrospective (not a controlled experiment) but nevertheless informative to those who prescribe drugs to patients. He also said there were thirty clinical trials underway that will possibly provide definitive information regarding efficacy and safety.
Actually, we already have the results of some clinical trials.
In a French study, a small sample of patients entering the Méditerranée Infection University Hospital Institute in Marseille testing positive for COVID-19, with certain exclusions, were recruited to be the test subjects in the study. Other patients elsewhere in the country served as the control subjects. The focus of this study was on patients who were asymptomatic or had mild symptoms. While the sample was small, the drug was shown to be statistically significant in reducing negative outcomes, which effects were improved with the use of Azithromycin.
LINK TO FRENCH STUDY:
https://www.sciencedirect.com/science/article/pii/S0924857920300996?casa_token=KY8wIYAQD5QAAAAA:_mZ5awZBBVFy-g-OyyimNSjKLcwjBDXa56_M5CF3iMQXQtODqNfmc9dRo81ZKywdvxWSfEkReQ
In a very small follow-up study of patients (sample size 11) with severe symptomatology, a second French study found that hydroxychloroquine did not help.
LINK TO SECOND FRENCH STUDY:
http://atomicfifteen.com/~TREATMENT_INEFFECTIVE_HYDROXYCHLOROQUINE.pdf
In a Chinese study that has not yet undergone peer review, 62 COVID-19 patients entering Renmin Hospital of Wuhan University were randomly assigned to control and experimental groups. In this study, hydroxychloroquine was found to help patients fight off pneumonia.
LINK TO CHINESE STUDY: https://www.medrxiv.org/content/medrxiv/early/2020/04/10/2020.03.22.20040758.full.pdf
A second Chinese study, involving 100 patients at multiple locations, obtained essentially the same results.
LINK TO SECOND CHINESE STUDY: https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_pdf/-char/en
We economists sometimes envy our counterparts in the so-called hard sciences, for their ability to conduct controlled experiments. Almost all of our statistical work is with "retrospective" data. Separating causation from correlation is sometimes impossible with non-experimental data; and, is never easy. We have developed some techniques to attempt to do this, but I'll not go further into this matter here. I'll just say that the medical sciences, anticipating the arrival of definitive information from controlled experiments, is not being unreasonable in merely reducing bias through techniques such as propensity score adjustment, when conducting retrospective studies.
Having said this, when speaking to persons outside the field, it is important to clarify that your findings are merely a lower limit as to the efficacy of hydroxychloroquine. If the finding was that hydroxychloroquine improved patient outcomes, then we'd know something. We'd know that the drug is effective, although - because of the bias - we wouldn't know by how much. As it is, all we know from the VA study is that hydroxychloroquine might not be effective
Butt, butt, butt....PDJT said it was a cure all. Especially the stuff from his factory. Right? NOT! /S
But the media only wants to talk about the SOOOOOOOPER BRILLIANT GENIUS doctor that Trump fired because he doesn’t think so.
Hydroxychloroquine,with zithromax, taken when you first get the Chicom cooties, will knock it out earlier and lower the symptoms.
It is obvious what is going on....FDA,CDC, and WHO, to name a few, all get money from BIG PHARMA which only makes its money from NEW DRUGS...not established, low cost, generics, like HCQ.
They want it swept under the rug so that it does not displace any new drug they can charge big money for.
It is simple — just follow the money.
Don’t forget the zinc.
Trump did not even know who the doctor was that got fired, but I immediately saw the “next whistleblower” in Schiff’s committee.
It must be started early when patients first develop fever and cough. If you wait until the patient develops hypoxia and actual pneumonitis, it is far less effective. Comparing its use in early onset outpatients to those who have required hospitalization is like comparing apples to oranges.
“...It is simple — just follow the money.....”
Yep. Just like always. The money trail always leads to interesting conclusions. Just follow Fauxie’s $3.7 million to the CCP’s bio-weapon lab.....the little commie weasel needs to be locked up for treason.
Zinc appears to be the main ingredient. HCQ is the conduit for Zinc to do the virus elimination.
But Zinc is hardly ever mentioned. I don’t get it.
hydroxychloroquine, azithromycin & zinc given when people first get symptoms but are still walking around and breathing.
The VA and NYC are giving it to people who are already in a bad way, mostly people of age and/or with some comorbidity.
Those are what the media will show because who cares if people die, the issue is never the issue, only viva la #RESIST
Highly reliable testing will soon be widely available. (1 Month)
Make HCQ widely available prophylactically to front line healthcare workers.
Prescribe HCQ EARLY in the diagnosis!
Let the sick and the "at risk" stay quarantined.
Another FReeper astutely pointed out last night that this doctor was a mid-level bureauwonk and POTUS would never personally reach down that deep into the ranks to fire someone.
His immediate supervisor made the call. And likely for legitimate reasons.
But the reporters did their best to paint him as Albert Schweitzer.
You’ve just posted the most rational way forward I’ve yet seen here.
This guy better shut up before the media crucifies him.
costa rica success with hydroxy without zithromax
...The medical director of the Caja, Mario Ruiz, as the director of Pharmacoepidemiology, Marjorie Obando Elizondo, the director of the Children’s Hospital, Olga Arguedas and the minister of Health, Daniel Salas, confirmed the use of the drug and the success in mitigating and containing the progression of the virus and also in reducing the number of patients who must be hospitalized in intensive care units....
...In the group of 88 patients recovered up to Friday, April 17, the use of this drug has allowed covid-19 control tests to be negative, he added.
Marjorie Obando confirmed that up to Thursday, April 16, hydroxychloroquine treatment had been given to 1,361 people, including cases suspected of being infected. Of these, 498 corresponded to confirmed patients....
Basically if you wait until things are bleak, they will stay that way. Early treatment not go home and if gets bad come back is the proper treatment plan.
What a nothing burger article. I thought from the title that they had some inside info on the large studies that are supposed to be published next week. I’m so tired of all this rehashing crap.
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