Posted on 04/12/2020 6:32:59 PM PDT by SeekAndFind
As labs around the world race to develop a vaccine, my colleagues and I are trying to find a better way to deliver it than the standard, cringe-inducing shot.
I am an immunologist and dermatologist, and my colleagues and I have been working on vaccines against the very related coronaviruses that cause MERS and SARS. We were able to use the resources and systems we had already developed to very rapidly create a vaccine candidate for this new SARS-CoV-2 coronavirus that we have tested in mice.
Called the PittCoVacc vaccine, it is a simple protein vaccine that is made from a small piece of one of the virus’s proteins, much like some of the flu vaccines that are now on the market.
There are currently many groups around the world working to develop a vaccine. What’s different with our design is the way the vaccine is delivered to people. Rather than inject the vaccine via a traditional shot, we use a small patch which has hundreds of small needles. We hope this delivery device will be simpler to produce in large numbers and administer to people.
Band-Aid with ‘microneedles’ Like traditional vaccines, our vaccine uses a small piece of the virus as an antigen, or “target” to stimulate the body’s immune response to make antibodies that recognize and bind to that target on the virus.
In this case, the target is from the virus’s S1 spike protein. This is the critical part of the virus that recognizes a protein receptor on our own human cells – and works much like putting the virus’s key in our own cells’ lock. Once the spike protein attaches to our cells, it enables the virus to enter our cells and cause the infection.
Our team at the University of Pittsburgh hopes that the antibodies our patients make after receiving the vaccine will bind to this key, and block it from fitting into the lock. That would prevent the infection.
A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is covered in spike proteins (S) that allow it to infect human cells. CDC/Alissa Eckert, MS; Dan Higgins, MAMS Using a simple protein antigen is common in vaccine design. What is new in this vaccine is the way we deliver that antigen: through a new delivery platform called a dissolvable microneedle array.
This is like a Band-Aid, but with hundreds of small needles, roughly the width of a human hair and just over half a millimeter in length. In this case, the microneedles are made out of a sugar-like substance mixed with the antigen.
When the vaccine patch is stuck on the skin, the microneedles poke into the skin and dissolve, releasing the antigen without causing pain or bleeding. This delivers the vaccine to a region of the skin that has specialized “scout” cells known as dendritic cells that recognize foreign invaders, and carry that information to the body’s immune system factories where antibodies are made.
Potential to scale quickly
When we tested this microneedle coronavirus vaccine in mice, we saw that it helped trigger the production of many antibodies which can then respond to the target protein on the virus.
Our team of Pitt and UPMC scientists hope to be able to test this vaccine in people very soon. Our next step is to obtain approval from the Food and Drug Administration to start these clinical trials. The entire clinical testing process can take a year to 18 months in normal times. But there is nothing about this pandemic that is “normal.” Very intelligent and hard-working scientists at the FDA are doing their best to assure that a vaccine which is both safe and effective will be available as soon as possible. Safety is everyone’s primary concern.
The advantage of our microneedle delivery system is that it is relatively straight forward to make and uses very little antigen. That means that production can be scaled up very quickly. In addition, unlike most vaccines that need to be kept cold from when they are made until they are given to the patient, this vaccine does not require this “cold chain” and can be distributed and stored at room temperature like Band-Aids. Cutting out this cold chain – a goal researchers have been pursuing for years – reduces cost and should facilitate global vaccine distribution.
Of course, we never know how well a vaccine will work until it’s tested in patients, but progress with this vaccine and others like it give us a reason for hope.
At the rate Covid is spreading and the discovery that it has spread far more than thought by people who showed no symptoms, a vaccine is too little, and too late. There is no more powerful vaccine than catching the virus and overcoming it yourself.
By the time it’s ready to hit the market, most people will be immune already. Their hope is a compulsory product, sold at gunpoint by our power mad Government MORON ruling class.
UPMC also sent out this notice last week.
“As COVID-19 infection rates continue to rise in other parts of the region and across the country, our testing data continues to reassure us that COVID-19 is not as widespread in the communities we serve. Social distancing at an early phase has allowed both our infection control experts at UPMC and our counties to track down cases and contain clusters. “
This statement differs from what the numbers look like from the Pittsburgh area. It suggests to me that the hard data is showing many fewer cases than what’s put out for public consumption.
So, when they apply the micro-needle bandaid they activate it by
giving you a “Hey, Bro” punch in the arm on the patch? lol
Microneedles, big needles... what’s the difference, really?
No thanks, see ya.
This is exactly how Gates wants to implant info that you have been vaccinated — and later, a complete ID.
We have a treatment and a prophylactic. We don't even know if this deadly strain of the virus (other strains have been around for decades) can even linger in the environment.
The reckless demand that inadequately tested vaccines be put into use at all is insane.
Maybe they can hire unemployed bouncers to deliver the activation punch. lol
Promise each homeless person 100 dollars if they will test the vaccine and sign a waiver of liability.
I don’t want no damn poison in my body. Just let me take The Trump Pills if I get the stupid virus.
Most modern vaccines do not give a lifetime immunity like the old ones did they need repeating every few years.
LOL
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