Posted on 03/18/2020 11:52:31 AM PDT by Red Badger
Cell death by a process called apoptosis inhibits inflammation in surrounding tissue. The finding that dying apoptotic cells release a tailored cocktail of metabolite molecules reveals a way in which they influence their living neighbours.
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“Marley was dead, to begin with. There is no doubt whatever about that.” The iconic opening lines of Charles Dickens’s novel A Christmas Carol convey the idea of the finality of death, a concept that pervades our thinking even when considering the demise of cells. A dead cell is, to echo Dickens’s description of Marley, “as dead as a doornail”. But just as Marley had an influence from beyond the grave to change the character of Ebenezer Scrooge in the story, cells that die can have a vital effect on the living cells around them. Writing in Nature, Medina et al.1 bring this process to life by uncovering metabolic processes in dying cells that have important consequences for the organism.
Every second, millions of cells die in our bodies owing to processes that are a normal part of life, such as tissue turnover and responses to environmental stresses2. The vast majority of these deaths occur by a process called apoptosis. This is a form of cellular suicide that is orchestrated by the actions of enzymes called caspases, which cleave hundreds of different intracellular proteins3. This regulated cleavage of various caspase targets effectively ‘packages’ the dying cell through an orderly dismantling process. DNA in the nucleus is cut into small pieces, the cytoplasmic ‘skeleton’ of filamentous actin protein is remodelled to break the cell into smaller fragments, and the exposure of a particular lipid on the cell surface signals to immune cells, such as macrophages, to take up (engulf) and digest the dying cell2.
(Excerpt) Read more at nature.com ...
Biology 101.
when you’re undernourished (ie low in nutrients) your body does not perform apoptosis. Therefore, abnormal cells flourish (which is cancer). There are a few nutrients that facilitate apoptosis, one of which is iodine.
More like Biology 1001.
*ping*
They even have audio now. As each cell dies it is heard to be saying, “It’s getting darker!”
Before FDR, cleavage was largely unregulated.
It still is in certain places...................
Also sulforaphane rich vegetables like Broccoli, Cauliflower, Cabbage..
For anyone else curious about the etymology.
If cleavage is outlawed, only outlaws will have cleavage...
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