Coronavirus Live Thread. No 14

3/11/2020

[Vermont Lt]

Time to stay calm and continue on....

Yesterday's thread is here:

http://www.freerepublic.com/focus/f-chat/3823193/posts

[LilFarmer]

Designated Report
@DesignatedRep
BREAKING: Utah Jazz Star Donovan Mitchell has tested positive for the Corona Virus, per @espn @wojespn

It is the second Jazz player to test positive for the virus within hours; Center Rudy Gobert tested positive last night.

https://twitter.com/DesignatedRep/status/1238119429667540992

[LilFarmer]

I’m wondering if we should all be thinking about mail-In ballots. I hate the, BUT I am not convinced that there are some who would deliberately try to spread this at polling stations. There have been liberals on Twitter talking about ways to infect Trump supporters.

[LilFarmer]

Should read, I am convinced. Sometimes I think my IPad is a Democrat.

[bgill]

The video of the coach with his head in his arms sure didn’t look like a common cold.

[Pollard]

My wife’s scheduled time off in May so we can go visit her family in VA. I say, we’ll see how things go.

[bgill]

Trump needed to stop rallies and meet ‘n greets two months ago but he hasn’t listened to us.

He and Pence never need to be in the same room together. One would think their detail would stress this.

Glad no more WH tours.

Awaiting Trump’s talk soon.

[LilFarmer]

Hey, I have question for y’all talking about the temp thing. So we got a cheap camper trailer because it is looking like hubby is going to have to work into the thick of it, and will likely have to self quarantine at some point. He decided he did not like my idea of a tent, lol.

Anyway, we were going to let it sit for 9 days, or we could crank up a heater in there. What would y’all do and how hot for how long for heating?

[RightGeek]

Instapundit Update - Morning 3/12 - https://pjmedia.com/instapundit/361147/

CORONAVIRUS UPDATE: Pence says thousands more U.S. coronavirus cases expected.

Czech Republic introduces drastic measures to deter spread of COVID-19.

China Coronavirus Adviser Expects Global Pandemic to Be Over by June.

Germany reports more than 2,000 coronavirus cases: Johns Hopkins University.

Scandinavia in Lockdown as Coronavirus Cases Hit 1,700.

Coronavirus: Schools and colleges to close in Republic of Ireland.

Washington state bans large gatherings and Seattle closes schools amid coronavirus pandemic.

Mayor De Blasio: 62 Confirmed Coronavirus Cases In NYC.

Nearly 200 Italians died of coronavirus in 24 hours.

Spain’s PM to hold meetings via video conference after minister diagnosed with coronavirus.

BBC ‘intent’ on keeping news on air during coronavirus outbreak.

NYSE Braces for Coronavirus With Potential Trading Floor Closing.

Why the coronavirus is different from flu and warrants major action.

President Trump is once again ‘putting Americans first’ with coronavirus ban.

Things may get worse with coronavirus before they get better, physician says.

[bgill]

FNC just reported Wajngarten is positive for CV.

[RummyChick]

thanks....

[cgbg]

Got it—thanks.

My source updated this morning:

https://docs.google.com/spreadsheets/d/18oVRrHj3c183mHmq3m89_163yuYltLNlOmPerQ18E8w/htmlview?usp=sharing&sle=true#

I will keep an eye on Alabama.

[bgill]

El Salvador is smarter than America.

[LilFarmer]

LA

Louisiana Coronavirus Updates: 14 presumed positive cases
...
Author: WWL Staff
Published: 9:45 AM CDT March 12, 2020
Updated: 10:32 AM CDT March 12, 2020

NEW ORLEANS — The Louisiana Department of Health has now reported 14 total cases of COVID-19, the disease caused by the new coronavirus.

The LDH reports 11 cases are Orleans Parish residents, one is from Caddo Parish, one from Jefferson Parish and one from Lafourche Parish. The case in Lafourche Parish had originally thought to be in Iberia Parish yesterday but was since updated by health officials.

https://www.wwltv.com/article/news/health/coronavirus/louisiana-coronavirus-covid19-live-updates-march-12/289-4a25ffdd-9ec2-4fa2-8a5e-91b25285bb0f

[bgill]

FNC - Trump has stopped rallies.

FNC - running the tape of Trump’s talk from a bit earlier.

[cgbg]

Bob:

I think it is a little more complicated.

Breathing is a more effective method of transmission, absolutely no doubt about that.

Touching is a less effective method, but since we touch so many surfaces that increases the likelihood of getting it from surfaces.

During the 1918 epidemic people started to get very serious about the social distancing thing, but the mail kept spreading the disease....

It is all probabilities....the virus will get you a lot of different ways.

[LilFarmer]

@ScottGottliebMD

This was 9 weeks ago. China only had 59 cases. Events moved fast. And so does this virus. We need to act with speed and aggression to stem its continued spread...

Referring to a tweet on 1/20

“This outbreak is deeply worrisome, and what appears to be an unnecessarily secretive response from Chinese officials will only add to the risk and uncertainty.”

https://twitter.com/scottgottliebmd/status/1237758645955440642?s=21

[bgill]

Just Harry staying in England is a hmmm moment. Heir and spare.

Keep an eye out for Kate maybe taking the kids on vacation away from William.

[WildHighlander57]

Found on one of the other threads (h/t bommer):

https://www.freerepublic.com/focus/f-news/3823826/posts?page=40#40

“So you thing its a Chinese bio weapon?
Actually yes. Coronavirus Bioweapon – How China Stole Coronavirus From Canada And Weaponized It. Greatgameindia.com ( a indian policy wonk website) has been tracing this from last year when no one heard of the Corona virus. It appears that samples were stolen from a lvl-4 National Micobiology Lab in Winnapeg Canada by a Chinese nationalist, who spent a few weeks vacatioing in Hunan. This information is way too detailed to be seen as BS. The Chi-coms are now working on a dis information campaign to blame the US for the virus. Canada btw has been investigation all this, but wont release its findings to the public. “

[Triple]

treatment article - a bit old but highly relevant and not widely circulated: http://www.natap.org/2020/newsUpdates/020620_03.htm Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed. An efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections. The 2019-nCoV belongs to Betacoronavirus which also contains SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV). Several drugs, such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS, although the efficacy of some drugs remains controversial.3 In this study, we evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir (GS-5734) and favipiravir (T-705) against a clinical isolate of 2019-nCoV in vitro. Standard assays were carried out to measure the effects of these compounds on the cytotoxicity, virus yield and infection rates of 2019-nCoVs. Firstly, the cytotoxicity of the candidate compounds in Vero E6 cells (ATCC-1586) was determined by the CCK8 assay. Then, Vero E6 cells were infected with nCoV-2019BetaCoV/Wuhan/WIV04/20192 at a multiplicity of infection (MOI) of 0.05 in the presence of varying concentrations of the test drugs. DMSO was used in the controls. Efficacies were evaluated by quantification of viral copy numbers in the cell supernatant via quantitative real-time RT-PCR (qRT-PCR) and confirmed with visualization of virus nucleoprotein (NP) expression through immunofluorescence microscopy at 48 h post infection (p.i.) (cytopathic effect was not obvious at this time point of infection). Among the seven tested drugs, high concentrations of three nucleoside analogs including ribavirin (half-maximal effective concentration (EC50) = 109.50 μM, half-cytotoxic concentration (CC50) > 400 μM, selectivity index (SI) > 3.65), penciclovir (EC50 = 95.96 μM, CC50 > 400 μM, SI > 4.17) and favipiravir (EC50 = 61.88 μM, CC50 > 400 μM, SI > 6.46) were required to reduce the viral infection (Fig. 1a and Supplementary information, Fig. S1). However, favipiravir has been shown to be 100% effective in protecting mice against Ebola virus challenge, although its EC50 value in Vero E6 cells was as high as 67 μM,4 suggesting further in vivo studies are recommended to evaluate this antiviral nucleoside. Nafamostat, a potent inhibitor of MERS-CoV, which prevents membrane fusion, was inhibitive against the 2019-nCoV infection (EC50 = 22.50 μM, CC50 > 100 μM, SI > 4.44). Nitazoxanide, a commercial antiprotozoal agent with an antiviral potential against a broad range of viruses including human and animal coronaviruses, inhibited the 2019-nCoV at a low-micromolar concentration (EC50 = 2.12 μM; CC50 > 35.53 μM; SI > 16.76). Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b). Remdesivir has been recently recognized as a promising antiviral drug against a wide array of RNA viruses (including SARS/MERS-CoV5) infection in cultured cells, mice and nonhuman primate (NHP) models. It is currently under clinical development for the treatment of Ebola virus infection.6 Remdesivir is an adenosine analogue, which incorporates into nascent viral RNA chains and results in pre-mature termination.7 Our time-of-addition assay showed remdesivir functioned at a stage post virus entry (Fig. 1c, d), which is in agreement with its putative anti-viral mechanism as a nucleotide analogue. Warren et al. showed that in NHP model, intravenous administration of 10 mg/kg dose of remdesivir resulted in concomitant persistent levels of its active form in the blood (10 μM) and conferred 100% protection against Ebola virus infection.7 Our data showed that EC90 value of remdesivir against 2019-nCoV in Vero E6 cells was 1.76 μM, suggesting its working concentration is likely to be achieved in NHP. Our preliminary data (Supplementary information, Fig. S2) showed that remdesivir also inhibited virus infection efficiently in a human cell line (human liver cancer Huh-7 cells), which is sensitive to 2019-nCoV.2 Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV. Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients suffering from the novel coronavirus disease.

[janetjanet998]

Seek Truth about Coronavirus
@about_seek
Replying to
@BNODesk
Breaking: Chinese Spokesman (equivalent to White house press secratary) via his official twitter account, speaking on behalf of CCP just tweeted: “It might be US army who brought the epidemic to Wuhan.”