Why prostate cancer is more aggressive in obese patients

Obesity has direct consequences on health and is associated with the onset of aggressive cancers, but the mechanisms underlying this phenomenon are little known. Researchers from the Institut de Pharmacologie et he Biologie Structurale (CNRS/Université Toulouse III -- Paul Sabatier) have recently elucidated one of these mechanisms in prostate cancer, one of the most common cancers in men: in obese patients, the adipose tissue surrounding the prostate gland facilitates the propagation of tumor cells outside the prostate. A patent has been filed for these results, which open new avenues for the treatment of prostate cancer, and are published in Nature Communications on January 12, 2016.

The researchers showed that adipocyte secretions can attract prostate tumor cells. By analyzing chemokines secreted by PPAT adipocytes they identified the factors involved, in particular chemokine CCL7, which interacts with one of its receptors, CCR3, present on the surface of prostate tumor cells. The scientists demonstrated that chemokine CCL7 is diffused through the PPAT to the area around the prostate and that it attracts tumor cells that express the CCR3 receptor towards the periprostatic adipose tissue, the gateway to the rest of the body.

The researchers then tested the influence of obesity on this mechanism. They showed that in obese mice who had been fed a high-fat diet, tumor progression and dissemination outside the prostate is greater than in mice with normal body weight. Adipocytes do indeed secrete more CCL7 in the case of obesity. When tumor cells that no longer express CCR3 are implanted in the prostates of mice, tumor progression and dissemination are significantly reduced, especially in obese mice.

The problem is not obesity per se. Obesity is a symptom of the problem of eating too much sugar. Cancers love sugar. Obesity loves sugar. Quit eating sugar (carbohydrates). That is all.

Several studies have explored why being overweight or obese may increase cancer risk and growth. The possible reasons that obesity is linked with cancer include:

Increased levels of insulin and insulin growth factor-1 (IGF-1), which may help some cancers develop
Chronic, low-level inflammation, which is more common in people who are obese and is linked with an increased cancer risk
Higher amounts of estrogen produced by fat tissue, which can drive the development of some cancers, such as breast and endometrial cancers
Fat cells may effect processes that regulate cancer cell growth. https://www.cancer.net/navigating-cancer-care/prevention-and-healthy-living/obesity-weight-and-cancer-risk
Obesity is a symptom of the problem of eating too much sugar.
With zero fat calories versus things like mayonnaise and fried chicken (esp. w/ skin) the it is more that of things like the latter and not only eating when you need energy to function and the amount needed, but because the clock says so and or you just want to eat and despite lack of strenuous as well as prolonged exercise -
Blessed art thou, O land, when thy king is the son of nobles, and thy princes eat in due season, for strength, and not for drunkenness! (Ecclesiastes 10:17)
And as for cancers love sugar
Cancer causes: Popular myths about the causes of cancer
Sugar and cancer – what you need to know
Of course, maybe you subscribe to the no carb diet fad, in which case I think we have an imbalance:
He causeth the grass to grow for the cattle, and herb for the service of man: that he may bring forth food out of the earth; And wine that maketh glad the heart of man, and oil to make his face to shine, and bread which strengtheneth man's heart. (Psalms 104:14-15)

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