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Eating more ketones may fight against Alzheimer's disease (Keto helps)
Society for Neuroscience ^ | December 9, 2019 | Aiwu Cheng, Jing Wang, Nathaniel Ghena, Qijin Zhao, Isabella Perone, M. Todd King, Richard L. Veech,

Posted on 12/26/2019 8:57:41 PM PST by ConservativeMind

A ketone-supplemented diet may protect neurons from death during the progression of Alzheimer's disease, according to research in mice recently published in JNeurosci.

Early in the development of Alzheimer's disease, the brain becomes over excited, potentially through the loss of inhibitory, or GABAergic, interneurons that keep other neurons from signaling too much. Because interneurons require more energy compared to other neurons, they may be more susceptible to dying when they encounter the Alzheimer's disease protein amyloid beta. Amyloid beta has been shown to damage mitochondria -- the metabolic engine for cells -- by interfering with SIRT3, a protein that preserves mitochondrial functions and protects neurons.

Cheng et al. genetically reduced levels of SIRT3 in mouse models of Alzheimer's disease. Mice with low levels of SIRT3 experienced a much higher mortality rate, more violent seizures, and increased interneuron death compared to the mice from the standard Alzheimer's disease model and control mice. However, the mice with reduced levels of SIRT3 experienced fewer seizures and were less likely to die when they ate a diet rich in ketones, a specific type of fatty acid. The diet also increased levels of SIRT3 in the mice.

Increasing SIRT3 levels via ketone consumption may be a way to protect interneurons and delay the progression of Alzheimer's disease.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimers; atkins; lowcarb; southbeach
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1 posted on 12/26/2019 8:57:41 PM PST by ConservativeMind
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To: ConservativeMind

Just eat a Keto diet, high-fat, low-carb.


2 posted on 12/26/2019 8:59:00 PM PST by dfwgator (Endut! Hoch Hech!)
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To: ConservativeMind

How do you eat ketones? I thought they were something your body made.


3 posted on 12/26/2019 9:02:13 PM PST by Lizavetta
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To: Lizavetta

While I do see a lot of evidence that adopting a ketogenic diet is an effective way to drop body fat, I’m not sold on ingesting ketones as a way to mimic the effects. To me it would be like someone saying “people who work out a lot are healthy and they sweat a lot, so here, drink some of this sweat, it’s going to do practically the same thing as a workout.”


4 posted on 12/26/2019 9:20:51 PM PST by jz638
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To: jz638

Your body produces Ketones, you don’t need to ingest them.


5 posted on 12/26/2019 9:22:02 PM PST by dfwgator (Endut! Hoch Hech!)
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To: ConservativeMind

Ketones are produced when fat is metabolized... Maybe folks aren’t eating enough fat?


6 posted on 12/26/2019 9:27:54 PM PST by Born to Conserve
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To: Lizavetta

Typically, this is done by your body in very low carb diet.

https://www.livestrong.com/article/517437-foods-that-have-ketones/


7 posted on 12/26/2019 9:31:40 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: BobL

Ping to you.


8 posted on 12/26/2019 9:44:15 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Born to Conserve
Ketones are produced when fat is metabolized... Maybe folks aren’t eating enough fat?

Hmmm. My wife doesn't have a gall bladder. I suspect she metabolized very little fat. How will she produce enough ketones?

9 posted on 12/26/2019 10:28:39 PM PST by FreeReign
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To: FreeReign

MCT oil. Three tablespoons a day that your liver can turn into enough ketones to make up for a 10% loss of brain function.

https://www.youtube.com/watch?v=XxGiQ7YrUYE

Start slow, as it will give you diarrhea if you aren’t used to it.

Costco has it, two 20oz bottles for about $22. Or Amazon, if you can wait a day or two. :)


10 posted on 12/26/2019 11:29:13 PM PST by JohnnyP (Thinking is hard work (I stole that from Rush).)
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To: JohnnyP

Fast forward the video to about 19m40s.


11 posted on 12/26/2019 11:49:22 PM PST by JohnnyP (Thinking is hard work (I stole that from Rush).)
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To: ConservativeMind

A Tablespoon of Coconut oil in your morning coffee does the trick...
https://ketogenicwoman.com/coconut-oil-on-the-ketogenic-diet/


12 posted on 12/27/2019 1:16:30 AM PST by AzNASCARfan
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To: ConservativeMind

I read the title as “eat more KITTENs”...

similar problem with those CPAP commercials.

Dementia is not funny;)


13 posted on 12/27/2019 4:01:17 AM PST by sodpoodle (Life is prickly - carry tweezers)
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To: JohnnyP

Do you know if the Costco oil contains just the C8 and C10 mct chains, or does it contain C12 as well, because the C12 (Lauric acid) is inferior. I paid about $24 for 32 Oz. for Left Coast mct oil on amazon.


14 posted on 12/27/2019 4:23:24 AM PST by FrdmLvr (They never thought she would lose.)
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To: ConservativeMind

Sure. And in 6 months there will be a “study” that says the opposite.

The article says essentially nothing, since it qualifies everything with “may.”


15 posted on 12/27/2019 4:44:44 AM PST by I want the USA back (If free speech is taken away, dumb and silent we are led, like sheep to the slaughter: G Washington)
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To: sodpoodle
I read the title as “eat more KITTENs”...

If you like the barbecue spare rib appetizer from your local Chinese restaurant, you probably are.
16 posted on 12/27/2019 5:02:16 AM PST by Karma_Sherab
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To: dfwgator

“Just eat a Keto diet, high-fat, low-carb.”

I’m with you, if I want Ketones, I’ll just go low-carb and my body will produce just the Ketones that I need (including Acetone).

No need to go to Home Depot and buy Acetone, as it tastes lousy and is lethal to drink.


17 posted on 12/27/2019 5:48:51 AM PST by BobL (I drive a pickup truck to work because it makes me feel like a man.)
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To: ConservativeMind

Check out https://keto-mojo.com. Lots of great info.


18 posted on 12/27/2019 6:01:33 AM PST by Atlantan
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To: sodpoodle; Karma_Sherab

Problem is kittens don’t have much fat...


19 posted on 12/27/2019 6:13:15 AM PST by Openurmind (The ultimate test of a moral society is the kind of world it leaves to its children. ~ D. Bonhoeffer)
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To: sodpoodle
I read the title as “eat more KITTENs”...


20 posted on 12/27/2019 6:14:16 AM PST by dfwgator (Endut! Hoch Hech!)
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