Posted on 01/25/2018 2:27:26 PM PST by Red Badger
Staphylococcus aureus - Antibiotics Test plate. Credit: CDC
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An antibiotic overlooked since its discovery 40 years ago could help develop new drugs against life-threatening infections caused by some of the world's most dangerous superbugs.
University of Queensland Institute for Molecular Bioscience (IMB) researchers synthesised the antibiotic, and increased its effectiveness against extensively drug-resistant bacteria, then collaborated with Monash University to evaluate the drug using animal models of infection.
Professor Matt Cooper, Director of IMB's Centre for Superbug Solutions, said the study was prompted by the urgent need for new drugs to counter widespread resistance to last-resort treatments.
"Octapeptins were discovered in the late 1970s but were not selected for development at the time, as there was an abundance of new antibiotics with thousands of people working in antibiotic research and development," Professor Cooper said.
"Given the very few researchers left in this field now, and the sparse pipeline for new antibiotics, we've used modern drug discovery procedures to re-evaluate its effectiveness against superbugs."
Professor Cooper said there were no new classes of antibiotics available for Gram-negative bacteria, with increasing incidence of extensive drug resistance around the world.
"Gram-negative bacteria are harder to kill as disease organisms, because they have an extra membrane to penetrate that is often hidden by a capsule or slime layer which acts to camouflage them from drugs and our immune system," he said.
"The emergence of resistance to meropenem, and now colistin, the antibiotic of last resort, means multi-drug and extensively drug-resistant bacteria are now a reality confronting clinicians.
"Octapeptin showed superior antimicrobial activity to colistin against extensively resistant Gram-negative bacteria in early pre-clinical testing.
"In addition, octapeptin was shown to be potentially less toxic to the kidneys than colistin."
Professor Cooper said the study laid the foundation for the development of a new generation of antibiotics to treat life-threatening infections.
The study is published in Cell Chemical Biology.
Explore further: Supercharged antibiotics could turn tide against superbugs
More information: Cell Chemical Biology (2018). DOI: 10.1016/j.chembiol.2018.01.005
Journal reference: Cell Chemical Biology Provided by: University of Queensland
Read more at: https://phys.org/news/2018-01-octapeptin-forgotten-antibiotic-worst-superbugs.html#jCp
Good thing they overlooked this one back then-the 70’s were when people were demanding-and getting-antibiotics for every damned sneeze, while responsible scientists were predicting this would cause just exactly what is happening now-attack of the superbugs...
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This is mainstream allopathic medic medicine bullshit
What they won’t tell you which I will if you can make your own super Duper 10 million-year-old antibiotic for free yes free
And what is that pray tell ?
collloidal silver
It kills 650 known pathogens all single celled bacteria and viruses known to the modern world
Don’t take my word for it just give her colloidal silver and know that you can make it for free with 3 9v batteries and distilled water in your own home every day as I do and never ever ever get sick again
No need for vaccines Tamiflu shots doctors nothing
Please play some moron try to argue with me about this and I will completely destroy you
I am tired of the mainstream medical establishment warning people’s lives left and right
Proofread much?
> “collloidal silver”
Stan Jones, the human Smurf.
Got instructions?....................
I would be curious too.
I’m guessing here, but I’m betting it uses a silver coin as an anode, passing an electric current thru the water dissolving and depositing the silver....................
For later.
L
“collloidal silver”
It’s a topical antiseptic. You may as well inject yourself with hand sanitizer.
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