Posted on 12/17/2017 3:49:50 PM PST by Morgana
July 11, 2017 CoG for Life
http://www.fiercepharma.com/vaccines/eager-for-marketing-approval-gsk-s-shingrix-passes-revaccination-test
With GlaxoSmithKline eager for marketing approval, Shingrix passes revaccination test
Awaiting a potential FDA approval, GlaxoSmithKline’s much-anticipated shingles vaccine Shingrix met its goal in a phase 3 study examining whether it can protect older adults who have previously received Merck’s Zostavax. If approved, CDC officials said they’re likely to recommend the GSK vaccine over Merck’s shot.
In the revaccination study, investigators found that Glaxo’s shot induces a strong immune response in people 50 and older who received Zostavax a minimum of 5 years before their Shingrix vaccination. Since previous studies have shown Zostavax’s protection wanes over time, the results could mean a new option for those who’ve already received the Merck vaccine, should Shingrix win FDA approval.
The data were presented at the CDC’s Advisory Committee on Immunization Practices (ACIP) meeting Wednesday, where members said the FDA is set to act on the GSK shot in the coming months. Apart from the U.S., GSK has also submitted its vaccine to authorities in Europe and Canada.
At the meeting, CDC medical epidemiologist Dr. Kathleen Dooling said a majority of members of a herpes zoster work group would recommend a preference for GSK’s Shingrix over the current vaccine, Merck’s Zostavax. That’s based on currently available data, Dooling cautioned, adding that the group is awaiting the GSK vaccine’s final price and a cost effectiveness analysis.
Experts at the ACIP meeting noted that should the FDA approve Shingrix by their October gathering, the group could choose whether to recommend the shot for national vaccination guidelines. A preference for GSK’s shot could gravely hurt Merck’s Zostavax sales, which totaled $685 million last year.
Just this week, life science commercial intelligence firm Evaluate predicted that Shingrix would climb to more than $1 billion in sales by 2022. The analysts found that Shingrix is the most valuable vaccine R&D project in the industry.
For their part, Glaxo executives have said the vaccine represents a big opportunity as it would steal market share and also drive uptake. GSK CEO Emma Walmsley recently told analysts the company’s “immediate focus” is to “deliver excellent commercial execution” on three drug launches, Shingrix among them.
Good one... looks like the two shots are between 2 and 6 months apart. Here's a bit more detail. https://www.gsk.com/en-gb/media/press-releases/gsk-announces-first-approval-of-shingrix-in-canada/
Is it the Old Iall Ones? (Wolfrider fan)
I mean Tall. Pushing72slackrequested.
in 2012 I had shingles around my right eye & forehead. It was nasty. A numbness remains, very sensitve to touch.
I got the chicken pox BIG TIME the first time. Each time thereafter it was much milder. Who knows why some of us keep getting it.
My hairdresser’s husband had shingles that spread to his brain and killed him. Poor guy was only 58.
I’ve never heard of a fatality from shingles to the brain but I have heard of blindness from shingles spreading into the eye itself. Having had it on my left forehead spreading down into my eyebrow and up as well as out into my hairline, I can say it’s excruciatingly painful, like it was drilling down into my brain. I can’t imagine having it in the brain itself. No idea how a rash can hurt so much.
No need for a Big Pharma ‘solution’ for shingles. Natural remedies work...
L-lysine is an amino acid that’s great for treating shingles, cold sores, and herpes outbreaks because it inhibits the growth of the Herpes zoster virus. The suggested dose is 1,000–1,500 mg three times per day. Take at the very first sign of symptoms. For prevention, 1,000 mg of L-lysine a day recommended.
IV vitamin C is also recommended for the natural treatment of shingles. Very high doses of this vitamin—which can only be administered intravenously—exhibit powerful antiviral properties, making it ideal for attacking the Herpes zoster virus and treating shingles naturally.
Olive leaf extract, with oleuropein boosts immune function and is very helpful in treating shingles naturally. High does are recommended.
Each if these natural remedies have successfully treated shingles. Of course they are also successful in treating other herpes viruses.
In 400 sentences or less, please state your overall position on vaccines.
My doctor recommended I wait for the newer vaccine. Since it is supposed to be so much more effective, I agreed with him.
I've had one vaccination since then, and, regardless of cost, won't hesitate to have another. Where do I send the money?
Chickenpox revisited totally sucks, but it’s not impossible.
>> shingles that spread to his brain
Really? That takes a lot of nerve.
They were high school sweethearts; married over 30 years with three adult children. When I first met her she was planning their daughter's wedding and was sad that he couldn't be there. Super lady. We're both Conservative Republicans in Massachusetts. We have some interesting conversations.
Under Complications.
https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Shingles-Hope-Through-Research#3223_11
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