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Human neural stem cells restore motor function in mice with chronic spinal cord injury
University of California, Irvine ^ | August 19, 2010 | Unknown

Posted on 08/19/2010 2:07:49 PM PDT by decimon

UCI study is first to show reversal of long-term hind-limb paralysis

A UC Irvine study is the first to demonstrate that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients.

Previous breakthrough stem cell studies have focused on the acute, or early, phase of spinal cord injury, a period of up to a few weeks after the initial trauma when drug treatments can lead to some functional recovery.

The UCI study, led by Aileen Anderson and Brian Cummings of the Sue and Bill Gross Stem Cell Research Center, is significant because the therapy can restore mobility during the later chronic phase, the period after spinal cord injury in which inflammation has stabilized and recovery has reached a plateau. There are no drug treatments to help restore function in such cases.

The study appears in the open-access, peer-reviewed journal PLoS ONE and is available online.

The Anderson-Cummings team transplanted human neural stem cells into mice 30 days after a spinal cord injury caused hind-limb paralysis. The cells then differentiated into neural tissue cells, such as oligodendrocytes and early neurons, and migrated to spinal cord injury sites. Three months after initial treatment, the mice demonstrated significant and persistent recovery of walking ability in two separate tests of motor function when compared to control groups.

(Excerpt) Read more at today.uci.edu ...


TOPICS: Health/Medicine; Science
KEYWORDS: adultstemcells; sci; spinalcordinjury; stemcells

1 posted on 08/19/2010 2:07:51 PM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers

Ping


2 posted on 08/19/2010 2:08:35 PM PDT by decimon
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To: decimon
wow, obamacare really is a miracle.

/s

seriously: Godspeed.

3 posted on 08/19/2010 2:21:04 PM PDT by the invisib1e hand (Gawd I love being an American.)
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To: the invisib1e hand
seriously: Godspeed.

To the researchers. Progress here could mean everything to many people.

4 posted on 08/19/2010 2:23:00 PM PDT by decimon
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To: decimon; humblegunner; Eaker; Allegra; TheOldLady; Salamander; 50mm; Markos33; Vendome
"Human neural stem cells restore motor function in mice with chronic spinal cord injury"

It is truly gratifying to know that human research will lead to fuller, happier lives for these otherwise crippled mice.
5 posted on 08/19/2010 2:57:52 PM PDT by shibumi (Pablo is Miley- wily, clever and detractive as all get out!)
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To: decimon

Too bad itll be rationed under obamacare.


6 posted on 08/19/2010 3:30:49 PM PDT by lowbridge (Rep. Dingell: "Its taken a long time.....to control the people.")
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To: decimon
“Pinky, are you pondering what I’m pondering?”
“Mein Fuhrer! I can valk!”
7 posted on 08/19/2010 3:33:02 PM PDT by RichInOC (No! BAD Rich! (What'd I say?))
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To: shibumi; decimon; humblegunner; Eaker; Allegra; Salamander; 50mm; Markos33; Vendome

Adult or embryonic? I read the article and couldn’t find where it said which.


8 posted on 08/19/2010 4:32:03 PM PDT by TheOldLady (Pablo is very wily.)
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To: TheOldLady; shibumi; decimon; humblegunner; Eaker; Allegra; Salamander; 50mm; Markos33

The structure of language was confusing.

Couldn’t say.


9 posted on 08/19/2010 4:42:58 PM PDT by Vendome (Don't take life so seriously... You'll never live through it.)
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To: TheOldLady

Since the article identifies them as “neural” stem cells, that, to me, indicates that they are already developed and differentiated beyond the level of an embroyonic stem cell .... so they are adult.


10 posted on 08/19/2010 5:28:58 PM PDT by RedWhiteBlue
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To: RedWhiteBlue

Thank you. Okay! I’m all for it.


11 posted on 08/19/2010 5:51:29 PM PDT by TheOldLady (Pablo is very wily.)
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To: decimon

It would have been cheaper to buy the mice wheelchairs.


12 posted on 08/19/2010 5:53:09 PM PDT by SunkenCiv ("Fools learn from experience. I prefer to learn from the experience of others." -- Otto von Bismarck)
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To: SunkenCiv
It would have been cheaper to buy the mice wheelchairs.

Et tu, Civ? ;-)

13 posted on 08/19/2010 6:06:35 PM PDT by decimon
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To: decimon; Coleus; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; StAnDeliver; ovrtaxt; ...

bump & stem cell/regenerative medicine ping

All PLoS, Public Library of Sciennce, articles are open access, i.e. FReebies, not just abstracts. The press release links the article. Thanks decimon!


14 posted on 08/20/2010 12:14:19 AM PDT by neverdem (Xin loi minh oi)
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To: decimon
If I can see paraplegics walk in my lifetime, it will be awesome.
15 posted on 08/20/2010 12:17:34 AM PDT by TomasUSMC ( FIGHT LIKE WW2, FINISH LIKE WW2. FIGHT LIKE NAM, FINISH LIKE NAM)
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To: neverdem

BTTT


16 posted on 08/20/2010 5:32:32 AM PDT by Dr. Scarpetta
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