Posted on 01/13/2010 10:53:51 AM PST by decimon
Appearing in the January 2010 issue of JLR
For those who do not drink, researchers have found that six essential oils –from thyme, clove, rose, eucalyptus, fennel and bergamot—can suppress the inflammatory COX-2 enzyme, in a manner similar to resveratrol, the chemical linked with the health benefits of red wine. They also identified that the chemical carvacrol was primarily responsible for this suppressive activity.
These findings, appearing in the January issue of Journal of Lipid Research, provide more understanding of the health benefits of many botanical oils and provide a new avenue for anti-inflammatory drugs.
Essential oils from plants have long been a component of home remedies, and even today are used for their aromatherapy, analgesic (e.g. cough drops), or antibacterial properties. Of course, the exact way they work is not completely understood. However, Hiroyasu Inoue and colleagues in Japan believed that many essential oils might target COX-2 much like compounds in wine and tea.
So, they screened a wide range of commercially available oils and identified six (thyme, clove, rose, eucalyptus, fennel and bergamot) that reduced COX-2 expression in cells by at least 25%. Of these, thyme oil proved the most active, reducing COX-2 levels by almost 75%.
When Inoue and colleagues analyzed thyme oil, they found that the major component –carvacrol– was the primary active agent; in fact when they use pure carvacrol extracts in their tests COX-2 levels decreased by over 80%.
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From the article: "Carvacrol, a component of thyme oil, activates PPAR-gamma and suppresses COX-2 expression" by Mariko Hotta, Rieko Nakata, Michiko Katsukawa, Kazuyuki Hori, Saori Takahashi, and Hiroyasu Inoue
Corresponding Author: Hiroyasu Inoue, Department of Food Science and Nutrition, Nara Women's University, Nara, Japan; Tel: +81-742-20-3458, Email: inoue@cc.nara-wu.ac.jp
The American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with over 12,000 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions and industry. The Society's student members attend undergraduate or graduate institutions.
Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology. The Society's purpose is to advance the science of biochemistry and molecular biology through publication of the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics, organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific work force.
For more information about ASBMB, see the Society's Web site at www.asbmb.org.
In thyme ping.
This is for high blood pressure or arthitis? Or both?
book mark also.
book mark also.
*ping*
Just thought I'd report my findings to those who suffer as I do. I have tried all the high dollar stuff and only recently discovered this oldie but goodie. It takes about a month(for me) to get the full effects, but I find it to be a keeper. My knees show absolutely no sign of inflammation and that condition has persisted for nearly two decades.
A bit hard on the tummy so take with plenty of fluids....or just water is fine. As a result, my heavy use of ibuprofen has stopped (2400 mgs per day or more).
Not sure. Better to wait for someone who actually knows something.
For arthritis? Rheumatoid arthritis? Toe mold?
What is Mobic?
Mobic is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Mobic works by reducing hormones that cause inflammation and pain in the body.
Mobic is used to treat pain or inflammation caused by arthritis.
Mobic may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Mobic?
This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Mobic. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
ttp://www.drugs.com/mobic.html
Hank
Frankly speaking, a heart attack would be a blessing for me, but that's another story.
I can’t tolerate NSAIDs at all any more. They have severe side effects on the GI system. It’s not just the risk of ulcers, which is widely publicized, but effects on the colon. Also, I’ve read that long-term use of NSAIDs tends to lower testosterone levels.
FWIW, about 20 years ago, at age 45, I began having joint problems after a bout of hepatitis. My joints became easily hurt and very slow to heal. I didn’t see a doctor about that because I didn’t want to begin the downward spiral of medication.
I did begin a pretty strict low-carb diet to lose weight. Amazingly, my joint problems all but disappeared along with my flab. I don’t know what was my joint problem or if what worked for me would help you. But it’s a thought.
Who in their right mind would want to suppress a COX to the second power? Shoosh - if I eat thyme my COX will shrink?
I just smell the flowers and watch birds these days. Totally retired as of the first of the year. I am not very mobile anymore. I will be 59 in about 6 weeks. Same age as Rush. I don't expect many more and males in my family rarely collect a social security check for very long.
Calcium. Vitamin D, and perhaps some other things, regulates how the body uses calcium.
I used to think I got enough sunlight for vitamin D but I’ve learned otherwise. Now I supplement.
I can't regulate what I have because the excess calcium is floating around in my lymphatic system and absorbed and stored in the vascular system which is a normal and necessary function.
I don't know of anything I can do. I have Internet key word searches that return results automatically to my computer. I have joined a number of sites that are supposed to be restricted to medical professionals to gather information of recent research papers and the like, and I just can't find anything that could help....but I'd like to hang around for a while longer so I try.
I do appreciate your concerns and I wish vitamin D or something simple would work, but I literally have pounds of free calcium just floating about as a result of joint deterioration and resulting grinding of bone on bone......
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