My poor daughter is doomed.
Come to think of it...so am I.
...and then, there are my granddaughters!!!
We just keep passing on that low center of gravity thing.
Posted on 10/09/2007 2:06:32 PM PDT by blam
Source: Oregon Health & Science University
Date: October 9, 2007
Hip Size Of Mothers Linked To Breast Cancer In Daughters
Science Daily — In a study of the maternity records of more than 6,000 women, David J.P. Barker, M.D., Ph.D., and Kent Thornburg, Ph.D., of Oregon Health & Science University discovered a strong correlation between the size and shape of a woman's hips and her daughter's risk of breast cancer. Wide, round hips, the researchers postulated, represent markers of high sex hormone concentrations in the mother, which increase her daughter's vulnerability to breast cancer.
A woman's hips are shaped at puberty when the growth of the hip bones is controlled by sex hormones but is also influenced by the level of nutrition. Every woman has a unique sex hormone profile which is established at puberty and persists through her reproductive life. The study's findings show for the first time that the pubertal growth spurt of girls is strongly associated with the risk of breast cancer in their daughters.
The study, carried out with colleagues in Finland and the United Kingdom., is described in an article in the American Journal of Human Biology. The authors followed up on 6,370 women born in Helsinki from 1934 to 1944 whose mothers' pelvic bones were measured during routine prenatal care. The study found that breast cancer rates were more than three times higher among the women in the cohort, born at or after term, whose mothers had wide hips. They were more than seven times higher if those mothers had already given birth to one or more children.
A woman's vulnerability to breast cancer, the study found, was greater if her mother's "intercristal diameter" -- the widest distance between the wing-like structures at the top of the hip bone -- was more than 30 centimeters, or 11.8 inches. The risk also was higher if these wing-like structures were round. The breast cancer risk was 2.5 times higher for the daughters of women in whom the widest distance was more than 3 centimeters greater than the distance at the front.
Barker, professor of medicine (cardiovascular medicine) in the OHSU School of Medicine as well as professor of clinical epidemiology at the University of Southampton in the U.K., is internationally known for discovering the relationship between low birth weight and the lifetime risk for coronary heart disease and other medical disorders, which the British Medical Journal has named the Barker Hypothesis. He has published more than 200 papers and written or edited five books about the developmental origins of chronic disease. He was honored in 2005 with the prestigious Danone International Prize for Nutrition for his pioneering research.
The OHSU study published today proposes that breast cancer is initiated in the first trimester of a pregnancy by exposure of the embryo's developing breast tissue to the mother's circulating sex hormones. The primary mammary cord, which gives rise to milk-producing breast lobules, develops in the fetus at 10 weeks. The fetal breast is known to be stimulated by circulating hormones; the intensity of the stimulation is such that half of all newborn babies have breast secretions.
"Our findings support the hypothesis that wide round hips reflect high levels of sex hormone production at puberty, which persist after puberty and adversely affect breast development of the daughters in early gestation," the authors commented. They could only speculate, they said, on the exact nature of this adverse effect but pointed out: "Catechol estrogen, a metabolite or estradiol, is thought to cause chromosomal instability by breaking DNA strands. High catechol estrogen concentrations in the maternal circulation could produce genetic instability in differentiating breast epithelial cells, which would make the breast vulnerable to cancer in later life."
"Epidemiological findings of this kind aren't designed to define precise biological or molecular mechanisms," said Grover Bagby, M.D., deputy director of the OHSU Cancer Institute. "However, for those of us involved in identifying the earliest molecular causes of cancer, these fascinating results define the types of questions we need to ask. This is a wake-up call telling us to pay attention to stem cell populations at the time of birth ... a good deal earlier than we might have otherwise done. It is important to consider these cell populations because only by understanding the initial cause can we begin to develop rational strategies to prevent this very common cancer."
The daughters who were the subjects of the study were all born during 1934-1944 at either Helsinki University Central Hospital or City Maternity Hospital, the two maternity hospitals in Finland's capital. The occurrence of breast cancer among them was ascertained from national registers of all hospital admissions and deaths in Finland. Three hundred of them had had breast cancer of whom 48 died from the disease. Their mean age when they were diagnosed was 54.
The findings shed new light on the link between breast cancer and nutrition. "Mothers whose daughters developed breast cancer were of similar height to the other mothers," Barker and Thornburg reported. "This suggests that they had similar nutrition through childhood. Our findings do not therefore indicate that good nutrition through childhood is linked to breast cancer in the next generation. But they do show that the pubertal growth spurt of girls, which reflects the level of nutrition, is strongly associated with the risk of breast cancer in their daughters."
Note: This story has been adapted from material provided by Oregon Health & Science University.
Wow, that’s some very detailed and specific study.
I wonder why study on women who’ve had abortions is not as detailed and specific?
Alex, what is because it's BS?
Poor Chelsea.
Yowzaa!
Is it just me or does this seem like a terribly narrow sample? Correlation isn't causation and there are numerous other genetic or environmental influences at play.
Poor Chelsea
Good article... and timely to women in my own family. Thanks for posting, I’ll be passing the link on.
Just sent this one off to my daughter who is involved in researching breast cancer and genetic links.
I was thinking the same thing as I read it.
All studies show a direct connection between abortion and breast cancer and explains the increase in the last generation.
But God forbid we give women facts that they can use to control their health future, better to talk about something they have no control over like their mothers hip size
My poor daughter is doomed.
Come to think of it...so am I.
...and then, there are my granddaughters!!!
We just keep passing on that low center of gravity thing.
There's a huge confound here: those were the years of worldwide depression and war. Europe was very hard-hit. Something about the nutrition of these girls could well have been affected. Show me the same results in the US, UK, China, India, and South America, and I'll be impressed. Correlation is not causation.
In any case this does not address the fact that the rate of breast cancer has skyrocketed in recent years. I don't think mothers' pelvic measurements has changed significantly in the last few score years.
A factor of seven seems ridiculously high, for the difference in risk between daughters of narrow hipped mothers and daughters of wide hipped mothers.
Either daughters of narrow hips have a really low risk, or daughters of wide hips have a really high risk, and this has never been noticed before. And doctors would notice, because many daughters have their mothers’ hips.
There may be some difference, but I am not believing seven-fold.
Mrs VS
“Wide, round hips, the researchers postulated, represent markers of high sex hormone concentrations in the mother, which increase her daughter’s vulnerability to breast cancer.”
Gee, sounds like natural selection in action. /sarc
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http://www.freerepublic.com/focus/f-chat/1909377/posts
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http://www.freerepublic.com/focus/f-chat/1909880/posts
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