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Vitamins disappoint in preeclampsia study
Seattle Post-Intelligencer ^ | April 26, 2006 | ALICIA CHANG

Posted on 04/26/2006 9:25:50 PM PDT by neverdem

AP SCIENCE WRITER

A disappointing new study found that vitamin C and E supplements given to healthy pregnant women do not reduce their risk of developing preeclampsia, a complication that can be lethal to both mother and child.

Similarly, a recent British study found that the supplements do not help women who run a high risk of preeclampsia, and might even harm their babies by leading to low birth weight.

Preeclampsia happens when vessels in the mother's womb constrict, cutting off blood and oxygen to the fetus. It occurs in late pregnancy and produces a spike in blood pressure. No one knows why it happens, and there is no effective treatment other than inducing early delivery.

The condition kills about 76,000 women and babies a year worldwide. In the United States, it occurs in about 8 percent of pregnancies and accounts for 15 percent of premature births.

Pregnant women routinely take a prenatal multivitamin containing small amounts of vitamins C and E, and a previous small study suggested that supplements might help prevent preeclampsia.

However, in light of the new research, some doctors are saying expectant mothers should not take supplements beyond what is in their multivitamin.

"Given the information that we have, I would not recommend taking additional vitamins C and E," said Dr. Arun Jeyabalan, an obstetrician at the University of Pittsburgh School of Medicine who had no role in the research.

The study, led by researchers from the University of Adelaide in Australia, was published in Thursday's New England Journal of Medicine.

In the study, 1,877 healthy women took either vitamins or dummy pills during their second trimester. The women were not allowed to take other over-the-counter supplements, but a prenatal multivitamin was allowed.

The supplement group took four pills a day totaling 1,000 milligrams of vitamin C and 400 international units of vitamin E until they gave birth. A prenatal multivitamin contains about 70 milligrams of vitamin C and 15 IUs of vitamin E.

About 6 percent of moms in each group developed preeclampsia, and 10 percent of babies in each group had serious complications, including death.

Women who took supplements had higher rates of blood pressure and hospitalization. But the results were not statistically significant, and researchers said the difference could have occurred by chance.

Health experts say the study leaves open the question of whether expectant mothers in Third World countries with inadequate diets might benefit from high-dose supplements. Several international studies are under way to help answer that question.

A large government-funded study involving about 10,000 healthy women is also under way in the United States.

In recent years, doctors have warned that vitamins can have harmful effects, especially at higher doses. Vitamins and other supplements, which are available at supermarkets and are relatively inexpensive, are loosely regulated and their health claims are unproven.

Large doses of vitamin E earlier were found to be ineffective against heart attacks and cancer.

On the Net:

New England Journal: http://www.nejm.org

Preeclampsia Foundation: http://www.preeclampsia.org


TOPICS: Health/Medicine
KEYWORDS: health; medicine; preeclampsia; vitaminc; vitamine; vitamins
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To: djf
Thanks for the suggestion. Too bad the study wasn't replicated, (BTW, not with the technique they used), but I'll try some vitamin C in my pooch, also 14 y.o. and occasionally lame.

Metabolic response during early stages of surgically-induced osteoarthritis in mature beagles.

Dietary supplementation with vitamin C resulted in increased serum protein content and increased cartilage formation, although ascorbate had no effect on enzyme activities.

21 posted on 04/27/2006 1:53:27 PM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: goodnesswins; All
I wonder which countries have the highest rates of preclamsia....would be interesting to know.

Excellent suggestion. That might provide a clue as to which mineral-deficient areas might correlate. Unfortunately, nutrition studies are still so very much in their infancy that the researchers don't even think in terms of vitamin/mineral/amino acid/enzyme synergy yet.

According to Ashmead in this book and elsewhere, even rates of vitamin absorption, let alone utilization, are dependent upon MINERAL levels in the body FIRST -- and even with mineral supplements, first mineral absorption and THEN mineral bio-availability are highly variable and dependent upon many factors, some of which are controllable.

22 posted on 04/27/2006 2:24:11 PM PDT by FreeKeys ("Journalists almost always screw up science stories." -- Charley Reese)
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To: FreeKeys

Interesting....I was also thinking about where the US would come in this list....and whether eating habits MIGHT have some effect on preclampsia (which my doc worried about when I was pregnant....years ago.)


23 posted on 04/27/2006 2:26:20 PM PDT by goodnesswins ( "the left can only take power through deception." (and it seems Hillary & Company are the masters)
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To: djf

Thank you. I know from experience of the benefits of Vit C. They'll never convince me otherwise.


24 posted on 04/27/2006 4:02:50 PM PDT by Conservativegreatgrandma
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To: djf

Thank you. I believe every word. I carry a plastic bag of Ester C in my purse. I wouldn't be without it.


25 posted on 04/27/2006 4:11:07 PM PDT by Conservativegreatgrandma
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To: diamond6
Hi Cgg, I'm curious, how many oranges would you have to consume to reach this amount?

I have no idea. The one thing about this is that I wonder what defect do we humans have that requires us to have this much supplementation to be healthy. But I KNOW it works. I won't guarantee it for anyone else but I can tell you I feel much better taking it.

I'm nearly 70 and have only been to a doctor twice in about 20 years. I can work long days and do heavy lifting.

26 posted on 04/27/2006 4:17:41 PM PDT by Conservativegreatgrandma
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To: djf
I've noticed similar results in our dogs. Once my veterinarian brother in law called me to see what I would recommend for a client's lame dog. I told him I would recommend Vit C (large doses), Vit E and pantothenic acid.

Since that time, Glucosamine has also come into being.

27 posted on 04/27/2006 4:22:55 PM PDT by Conservativegreatgrandma
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To: Conservativegreatgrandma

How do you consume this amount? Is it all supplementation or regular food like brocolli or cantaloupe?


28 posted on 04/27/2006 4:57:25 PM PDT by diamond6 (Everyone who is for abortion have been born. Ronald Reagan)
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To: diamond6
No. I take 1 gram orally at a time. At least twice a day, in the am and before I go to bed but usually at least once during the day, sometimes more.

I use Ester C. I have found I can use it in the middle of the night, on an empty stomach with no problem. My stomach never even knows it's there.

29 posted on 04/27/2006 5:28:06 PM PDT by Conservativegreatgrandma
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To: djf; All

Speaking of politics; http://www.ceri.com/trypto.htm


30 posted on 04/28/2006 7:06:34 AM PDT by oxcart (Journalism (Sic))
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To: Conservativegreatgrandma

Does it help you sleep?


31 posted on 04/28/2006 8:28:05 AM PDT by diamond6 (Everyone who is for abortion have been born. Ronald Reagan)
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To: diamond6

I don't think so.


32 posted on 04/28/2006 9:24:37 AM PDT by Conservativegreatgrandma
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