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Low air pressure 'raises DVT risk on flights' (Blood clots in veins)
Scotsman.com ^ | 10-Mar-06 | LYNDSAY MOSS

Posted on 03/09/2006 9:59:32 PM PST by neverdem

HEALTH CORRESPONDENT

LOW air pressure and reduced oxygen on flights may be linked to an increased risk of deep vein thrombosis (DVT), rather than just cramped conditions.

A study published in the Lancet found that participants who sat on a plane for eight hours showed signs of developing DVT, but those who sat in a cinema seat did not.

The experiment looked at changes in the blood of 71 people before, during and after an eight-hour flight.

The same participants were also monitored during eight hours in the cinema and eight hours in their everyday lives.

The team, from Leiden University Medical Centre in the Netherlands, found evidence of DVT developing during the eight-hour flight, but not when the volunteers spent the same time sitting in the cinema.

Researcher Professor Frits Rosendaal said this suggested that something other than just sitting for long periods was linked to the risk of developing a clot in susceptible people.

DVT is a clot which develops in a deep vein, usually in the leg, and affects about one in 2,000 people in the UK a year.

Some people face a greater danger of DVT because they are older or have other risk factors.

It has been linked to long-haul flights, giving it the name "economy class syndrome". It can prove fatal if a clot travels in the blood to the lungs.

Prof Rosendaal recruited 15 men and 15 women with no known risk factors for DVT.

The study also involved 11 women carrying the factor V gene and 15 women taking the contraceptive Pill - both known risk factors for DVT.

Another group of 15 women who were both carrying the gene and taking the Pill was included.

After the flight, 17 per cent of volunteers showed early signs of possible clotting in the blood.

But after eight hours in the cinema only 3 per cent showed the same signs, dropping to just 1per of volunteers during everyday activities.

The risks were greatest for those with both risk factors.

The study found that 43 per cent of those with the factor V gene and taking the Pill were showing early signs of possible clotting. This compared with 9 per cent of those with one risk factor and 10 per cent of those with no risk factors.

The role of the Pill as a risk factor was cited in the death of 23-year-old Katie McPherson, a student from Renfrewshire, who became a DVT victim in January 2003.

Katie's family claimed a 25-minute flight to Belfast from Glasgow a few weeks before Ms McPherson fell ill, and a change to her contraceptive Pill only ten days before her illness, could have contributed to her death.

Prof Rosendaal said: "The bottom line is that there is something happening on the plane as well as immobilisation. We only think it is the low pressure and low oxygen, but we can't be sure.

"Immobilisation is probably still the most important thing linked to the development of DVT, but something else is occurring that does not happen on the ground."

Prof Rosendaal said that increasing air pressure on planes could help, but this was difficult to achieve.

Farrol Kahn, of Aviation Health, which promotes the wellbeing of air passengers, said the study was very important.

"We have known since the 1980s that immobilisation on board planes probably does increase the risk of DVT."

Mr Kahn said that people could reduce their risk of DVT by wearing flight socks during long trips.


TOPICS: Health/Medicine; Science
KEYWORDS: deepveinthrombosis

1 posted on 03/09/2006 9:59:35 PM PST by neverdem
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To: El Gato; JudyB1938; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; ..
Harm Done: Codifying the decline of the medical profession ( The Hippocratic Oath is dead)

NASA'S CASSINI DISCOVERS POTENTIAL LIQUID WATER ON ENCELADUS

Here's some of the pics that made NASA draw this conclusion.

http://www.nasa.gov/mission_pages/cassini/main/index.html if you want to see more pics

FReepmail me if you want on or off my health and science ping list.

2 posted on 03/09/2006 10:27:10 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem
Prof Rosendaal said that increasing air pressure on planes could help, but this was difficult to achieve.

If only someone would invent a device of some kind that would compress air....hmmmmm...

3 posted on 03/10/2006 2:47:09 AM PST by Jeff Chandler (Peace Begins in the Womb)
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To: Jeff Chandler

Raising the Air Pressure is easy. Not blowing the plane apart while at altitude is the hard part.


4 posted on 03/10/2006 4:47:29 AM PST by Lost Dutchman
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To: neverdem

That's why I take ibuprofen on long flights.


5 posted on 03/10/2006 6:56:41 AM PST by MarMema (Buy Danish, support freedom)
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To: MarMema
Your choice of drug is a curious one. The antithrombotic effect of NSAIDS, including ibuprofen, is quite minimal. If you desire such protection you are much better off with aspirin.
6 posted on 03/10/2006 10:18:50 AM PST by US admirer
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To: US admirer

"The antithrombotic effect of NSAIDS, including ibuprofen, is quite minimal. If you desire such protection you are much better off with aspirin."

Thanks, you just save me posting the same thing.


7 posted on 03/10/2006 11:28:22 AM PST by Grampa Dave (Visit Free Republic to enjoy shameless Schadenfreude as the lies of liberals are exposed!)
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To: MarMema; El Gato; JudyB1938; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; ...
That's why I take ibuprofen on long flights.

I would put my money on a baby aspirin.

Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin

P.S. Can you access that abstract without registering with the New England Journal of Medicine, NEJM? I'm registered, but I don't subscribe to the NEJM, JAMA, BMJ, Lancet, Nature and Science. Sometimes they permit free access to complete articles, but I'm not going to fund such politically correct publications. I'm curious about the access of the general public regarding the public's access to their abstracts, so I really would appreciate some feedback on this thread.

P.P.S. IIRC, I originally found that abstract using PubMed some years ago. Today, I located that abstract by entering aspirin and ibuprofen into NEJM's search function, after becoming frustrated with all the results at PubMed using those same terms. Thank God for memory neurons!

8 posted on 03/10/2006 11:44:43 AM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem
So everyone should take a baby aspirin and wear graduated pressure stockings when flying?
9 posted on 03/10/2006 11:58:31 AM PST by armymarinemom (My sons freed Iraqi and Afghanistan Honor Roll students.)
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To: US admirer

Antithrombotic activity isn't the whole picture. The clotting cascade is a bit more complex than a lump of platelets.
But take what you like.....I know what I am doing.


10 posted on 03/10/2006 12:05:37 PM PST by MarMema (Buy Danish, support freedom)
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To: armymarinemom
So everyone should take a baby aspirin and wear graduated pressure stockings when flying?

If you don't have a history of aspirin allergy or ulcers from non-steroidal anti-inflammatory drugs, NSAIDs, that seems to be prudent for flights longer than eight hours in length. Getting up and stretching your legs was also recommended on a televized news segment. Someone should tell the air marshals.

11 posted on 03/10/2006 12:12:52 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: US admirer; MarMema

Another possibility is vitamin E. Enough of a thinner to merit warning to stop taking it before an operation.


12 posted on 03/11/2006 3:59:57 PM PST by Spirited
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