[ConservativeMind]

A search shows ApoM can be increased by simvastatin and exercise, but another study I dug up specifically shows intermittent fasting definitely increases ApoM, even if it does not change the amount of HDL. Instead, it changes the amount of HDL with ApoM in it, as a proportion of HDL.

The researchers found that early AMD problems with retinal health and cholesterol deposits reversed with higher amounts of ApoB in HDL.

I will post that next.

[ConservativeMind]

Intermittent fasting (IF) “increased significantly” ApoM levels.

Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial

https://pmc.ncbi.nlm.nih.gov/articles/PMC11395628/#Tab1

“Plasma apoM levels increased significantly after 12 weeks of IF (Fig. 1B). In agreement with our results, previous studies have shown an association between apoM and BMI [21, 22].”

[ConservativeMind]

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[SaveFerris]

(I dug up specifically shows intermittent fasting definitely increases ApoM)

I’m glad you said that because I do fast at odd intervals often 1-2 times a week.

[OftheOhio]

I’ll never take a statin again. There’s a reason for that. 893 ratings from patients. Could drinking poison Hemlock be any worse. I have zero inflammation in my body now in my 70s and that’s from no longer allowing myself to be a guinea pig.
https://www.askapatient.com/viewrating.asp?drug=19766&name=ZOCOR

https://www.askapatient.com/searchresults.asp?searchField=simvastatin#google_vignette

[imardmd1]

bmk

[norwaypinesavage]

Thanks for posting this. It’s very important to me. My father had heart disease and was blind from AMD, when he died from Alzheimer’s in his mid 90s. My mother also died of “dementia” at 89. I am presently taking a statin for elevated cholesterol but it is now well under control. I had considered stopping it, though this article would indicate I should keep on taking it (as my doctor recommends).

Thanks for all your efforts in posting medical news. It’s always interesting and a is great resource for us all.

[tired&retired]

Thank You, Thank You, Thank You for posting this article.

AMD runs in my family. Mother, brother and sister are legally blind due to it.

My thoughts were that it was caused by hypoxia. I’ve observed many causes of the hypoxia, from hemoglobin deficiencies to vascular constriction.

My own theory has always been that the Vascular endothelial growth factor (VEGF) that causes wet AMD was caused by the hypoxia. That’s why people usually have wet in one eye and dry in the other.

The Zeaxanthin serves as an O2 reservoir and when Drusen turns hard, the O2 reserves become deficient causing hypoxia.

It would be interesting to see if people who have sleep apnea are more prone to AMD.

Again, thank you for posting these great articles.

[Hyman Roth]

I thought masturbation was the leading cause of blindness

[Overtaxed]

https://www.amazon.com/Ancestral-Dietary-Strategy-Prevent-Degeneration-ebook/dp/B07ZS2619S

Chris Knobbe: Ancestral Dietary Strategy to Prevent and Treat Macular Degeneration

The main takeaway is to eat the foods people ate before processed foods. I found this book a year ago after drusen showed up on my macula. Nine months of following his advice (no seed oils!) resulted in no drusen in sight at my yearly eye exam.

[OftheOhio]

I just wanted you to know my previous comment was not a slam on you. In fact, one of your previous articles about choelesterol had some epic comments and was thought-provoking, especially about cancer.

I find it unbelievable that we haven’t cured cancer with all the monies that have gone to research for decades.