The optimal time to drink coffee isn't when you normally have it

While it's often associated with wakefulness, experts claim there may be benefits to holding off on that cup of joe for a different time of day.

Cortisol, a stress hormone, is highest in our body right as we wake up, according to Julia Zumpano, a registered dietitian with the Cleveland Clinic Center for Human Nutrition.

Caffeine is a stimulant, so if it's consumed (by drinking coffee, for example) when cortisol is high, that can increase stress levels that were already high at the beginning of the day.

"The [cortisol] decline is different for everyone but typically occurs one-and-a-half to two hours after you wake," Zumpano said.

Inflamation is what allows the cancer cells to enter the tissue.

Thanks!

I’ve been dealing with food sensitivities that modern medicine hasn't been able to clearly diagnose. My main triggers seem to be:

Fermented foods or substances
High-tyramine foods (e.g., tomatoes)
MSG and food additives
Most processed foods and alcohol (some types are worse than others)

After a lot of trial and error and self-diagnosis, I believe I have a histamine intolerance, and possibly an issue processing tyramine—maybe even something involving monoamine oxidase (MAO) dysfunction. I’ve recently learned that all of these are influenced by DAO (diamine oxidase) enzyme, which is leading me to my next step: testing for DAO activity levels to confirm or rule this out.

During my research, I discovered the AOC1 gene, which indirectly encodes for DAO. Mutations or variations in this gene may contribute to DAO deficiency, and interestingly, it has also been linked in some studies to fibromyalgia. While I have a few symptoms that resemble fibromyalgia, I don’t believe I have that condition.

Adding another layer to this: I’m a survivor of mantle cell lymphoma (MCL), a rare form of lymphoma driven by the t(11;14)(q13;q32) genetic translocation. That got me wondering: could chronic histamine intolerance or stress from food reactions play a role in triggering cellular changes, maybe even contributing to this kind of genetic mutation? I know this might be reaching, but I can’t help but feel there’s a common root—possibly involving DAO dysfunction—that connects the dots.

Would love to hear any thoughts, similar experiences, or feedback on this line of thinking. Has anyone explored DAO deficiency in connection to larger systemic or even oncologic issues?

Has anyone explored DAO deficiency in connection to larger systemic or even oncologic issues?

I’m working with my oncologist at Duke University Hospital to learn more about this. I gave him a few journal articles and peaked his interest.

I made my own DAO by sprouting green peas in the dark for 10 days. I did 5 lbs of them and then Greece dried the sprouts.

I powdered the results and put them in vegetarian size 0 capsules. The result is far stronger in DAO content than the DAO supplements available. It’s just pea sprouts so I think you could eat a cereal bowl of the powder and it would not hurt you. I made a gallon of the pea sprouts powder in my first batch, enough to fill about 10,000 capsules.

The results are very profound and immediate. Much to my surprise, the results are experienced 10 minutes after taking a capsule.

I’m now working on having them lab tested for DAO level. They are 100% green peas sprouts, nothing else.

I just give them away. They are so easy and cheap to make that I enjoy helping people get better.

I’m turning a stainless steel bread proofing cabinet into a sprouting cabinet with automatic spray rinsing and fans for air circulation. That will provide a constant supply of sprouts.

I have an extra large commercial freeze dryer so I can do about 8 to 10 lbs of peas every two days.

I’m just having fun.

Has anyone explored DAO deficiency in connection to larger systemic or even oncologic issues?

Yes -- me and ChatGPT.

As I’ve mentioned before, my lymphoma (mantle cell lymphoma) was driven by a chromosomal translocation—t(11;14)—a well-documented genetic trigger for this form of cancer.

Recently, I had an in-depth discussion with an AI assistant about a potential link between DAO deficiency and cancer risk, particularly how a lack of DAO activity can lead to chronic histamine overload, inflammation, and immune system stress.

The theory I’m exploring is this: DAO deficiency → histamine/tyramine buildup → systemic inflammation and cellular stress → increased risk of DNA damage or mutation → possible contribution to cancer development, especially in genetically susceptible individuals.

Of course, this is speculative—but the idea that chronic inflammatory conditions may prime the environment for oncogenic mutations is gaining traction in research circles.

I'd love to hear from anyone else who’s explored the histamine-cancer or nutrigenomic-oncology connection, or who has experience with DAO-related issues and chronic illness like yourself.

Here's the link to the conversation if you’re curious:

https://tggtest.com/tggmisc/freerepublic/dao_lymphoma.htm

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