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Hypertension causes kidney changes at an early stage, finds study
Medical Xpress / Medical University of Vienna / Hypertension ^ | March 27, 2025 | Christopher Paschen et al

Posted on 04/05/2025 9:09:17 PM PDT by ConservativeMind

A research team has investigated structural changes in kidneys of patients with hypertension and type 2 diabetes. The results show high blood pressure can lead to abnormalities in the podocytes, specialized cells in the renal filter, even without other pre-existing conditions such as diabetes.

The results underline the importance of early detection and consistent treatment of high blood pressure in order to prevent kidney damage.

To arrive at results, the research team analyzed kidney tissue from a total of 99 patients.

The investigation was conducted on unaffected renal tissue samples from tumor nephrectomies (performed between 2013 and 2018), a surgical procedure in which a kidney is removed in whole or in part to treat a kidney tumor.

Using modern imaging and computer-assisted methods, the size and density of the podocytes and the volume of the renal corpuscles (glomeruli) were determined in the tissue samples. Podocytes are specialized cells of the renal corpuscles (glomeruli) that play a crucial role in the filtering function of the kidney. Their size and density are important indicators of the health of the kidney tissue.

Artificial intelligence in the form of deep-learning-based image analysis was used for the analysis.

"The results show that patients with hypertension have a reduced density of podocytes compared to healthy controls and that their cell nuclei are enlarged compared to those of healthy controls," reports Christopher Paschen. These changes occurred independently of the additional diagnosis of type 2 diabetes and likely represent the first microscopically visible step towards impaired renal function.

The authors see this as an indication that high blood pressure can cause structural damage to the kidneys at an early stage and before clinical symptoms appear. "Early detection and treatment could help to slow the progression of kidney disease and prevent long-term damage," say Rainer Oberbauer and Heinz Regele.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: health; hypertension; kidney; minitard
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To: ConservativeMind

MiniTARD’s reply to you is one of the most ignorant and arrogant statements I’ve ever seen posted on FreeRepublic. Keep up the good work you do, CM!


21 posted on 04/08/2025 7:42:29 AM PDT by LittleBillyInfidel (This tagline has been formatted to fit the screen. Some content has been edited.)
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To: miniTAX; LittleBillyInfidel
miniTAX, I let you drone on with your wrong understanding, and it is fun to see you look stupid, but I will end this argument now.

What I said in my post:

“Stay on top of your blood pressure and don't let it stay high. Loosen that belt, or wear less restrictive clothing, diet down, reduce stress, or take medicine or supplements to minimize the damage that constant high blood pressure causes everywhere.”

What you have maintained:

“A simple change in diet is what should be prescribed, first and only. Anyone recommending blood pressure medecine in such case is not a doctor but a drug dealer or a moron.”

Can you see in bold how I first told everyone to “diet” to help address this? How blind must you be to keep maintaining being so wrong or maybe you just to hassling others?

22 posted on 04/08/2025 10:09:27 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

‘Can you see in bold how I first told everyone to “diet” to help address this? How blind must you be to keep maintaining being so wrong or maybe you just to hassling others?”


You said ‘diet down OR take medicine’, in the context of the study you posted, which is ‘at an early stage and before clinical symptoms appear’. That’s verbatim from the paper, so why do you deny such simple and irrefutable facts by putting in bold just one tidbit without its context?

My beef with your foolish advice was not about the ‘diet down’ part (even if in itself, it’s a meaningless platitude) but about the ‘take medicine’ part.

You should NOT take hypertension medicine at an early stage and before clinical symptoms appear when you know that a low carbs diet WITHOUT any medicine can get you back to normals in a matter of weeks. Clinicians like dr Westman or Unwin have years of success thousands of testimonies to prove me right.
You claimed I’m wrong, how so? Ah, you don’t give any argument, fact or logic, you just make claims. Got it.


23 posted on 04/08/2025 1:45:14 PM PDT by miniTAX
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To: LittleBillyInfidel

‘You actually quadripled down on how ignorant you are and - unbelievably arrogant in attacking “ConservativeMind” in doing so’


Yeah sure, ‘quadripled’, said the quadriplegic spelling nazi.
And now, you try to piggyback on ConservativeMind to deflect from the gutter level of your arguments, how pathetic! ConservativeMind has always been classy and we never made ad hominem while strongly disagreeing, anything but gross and petty like you, so piss off, old sick man.


24 posted on 04/08/2025 2:32:22 PM PDT by miniTAX
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