Posted on 02/17/2025 9:29:13 PM PST by ConservativeMind
Antidepressants like Prozac treat mental health disorders, but new research suggests they could also protect against serious infections and life-threatening sepsis.
The study follows recent findings that users of selective serotonin reuptake inhibitors (SSRIs) like Prozac had less severe COVID-19 infections.
Another study found that Prozac—also known as fluoxetine—was effective in protecting mice against sepsis.
While our immune systems do their best to protect us against infections, sometimes they can overreact.
An obvious solution would presumably be to suppress the inflammatory response, but doing so can actually make patients more vulnerable to infection.
Instead, an ideal treatment would 1) proactively control the intensity and duration of the immune response to prevent any bodily damage and 2) kill the infection that puts the body at risk to begin with.
The researchers studied mice with bacterial infections and separated them into two categories: one pretreated with fluoxetine and the other not. Excitingly, they saw the mice pretreated with fluoxetine were protected from sepsis, multi-organ damage, and death. The team then launched follow-up experiments.
First, they measured the number of bacteria. Mice treated with fluoxetine had fewer bacteria at this stage, signifying a less severe infection. The findings demonstrated that fluoxetine had antimicrobial properties, which allowed it to limit bacterial growth.
Next, the researchers measured the levels of different inflammatory molecules. They saw more anti-inflammatory IL-10 in their pretreated populations and deduced that IL-10 prevented sepsis-induced hypertriglyceridemia—a condition in which the blood contains too many fatty triglycerides. This enabled the heart to maintain the proper metabolic state, protecting the mice from infection-induced morbidity and mortality.
The team decoupled this IL-10-dependent protection from multi-organ damage and death from their earlier discovery of fluoxetine's antimicrobial effects, in turn revealing the drug's dual-purpose potential to 1) kill pathogens and 2) alleviate infection-induced damage to the body.
(Excerpt) Read more at medicalxpress.com ...
smh
smh too.
studies to support re-purposing commonly over-prescribed drugs in case RFKjr or Doge team exposes scam psycho ailments that could dry up billions in addiction gravy train?
Impossible. I learned from Dr. Fauci himself that drugs can be used for one and only one purpose. Horse paste doesn’t treat the WuFlu so neither can Prozac. It’s Science™!
I wonder if other drugs that increase serotonin but not exclusively by reuptake inhibition would also have the anti-bacterial effect? An example would be trazadone, which I take to improve sleep. And something like buspirone also. Guess I’d better read the study for clues.
Found:
“Fluoxetine and Trazodone: An exploratory analysis indicated that individuals using fluoxetine or trazodone had a lower risk of bacterial infection”.
A large overdose will make sure you never get cancer either.
I call BS on this nonsense. Yes, let’s take a mind altering drug in order to possibly avoid sepsis.
Maybe Reader’s Digest was correct, “Laughter is the Best Medicine.”
Let me again give a warning about these drugs. Some of you may be walking around with genetic issues that can cause real problems but you don’t know it because Doctors never bothered to check. AND don’t seem to know much about it.
It is a complicated subject that is way too involved for discussion here.
Just know that this class of drugs are dangerous for some people. I am one of them.
Both my parents gave me a defect where I have zero ability to process a drug using that enzyme to metabolize. And if the drug uses more enzymes than just one..we’ll guess what..I have multiple enzyme issues
So be very careful if you are aware that you have had issues in the past processing a drug.
This class of drugs can give you really nasty side effects including mental issues for those with genetic problems in their metabolizing genes.
Also, if just one parent gave you a bad gene you can still have problems processing drugs.
I came across a study that I can’t find now that talks about why hydroxychloriquine didn’t work on many severe covid patients. Not because it can’t but because many of the patients had genetic problems processing the drug.
So I was a good candidate to see what would happen when I got covid in December but I only tried a few pills because I was afraid of going toxic. If covid had caused lower lung problems I was prepared to go all in..but it didn’t
There just aren’t enough studies on many of these repurposed drugs so it becomes a crapshoot
It’s a self defeating medication. Sepsis can kill you so take antidepressants, defeat sepsis and celebrate with suicide.
I’ll pass.
Some of those studies were outright bogus propaganda - why? - because they didn't include zinc, which is the real "stopper" of covid. They didn't use zinc purposefully in order to discredit Trump.
These ppl are no less than lying murderers in my opinion.
Now, if you have trouble metabolizing HCQ bc of enzyme issues, have you tried any substitutes?
For instance, I take quercitin w/ bromelain every day (with zinc).
I thank God, because everyone else around me/at work has been getting sick over the last few months...but not me.
I hope you can find something that works for you FRiend - at least take zinc...(with C & other stuff that's been posted here frequently).
This is one of the tables that researchers use. Notice Quercetin is problematic for many.
https://drug-interactions.medicine.iu.edu/MainTable.aspx
For me, it is listed as an inhibitor on some of the variant gene categories I have. Even if my particular variant is not on the official list for this defect it may still be affecting me and they just haven’t caught on for my variation. Genetic testing is far more advanced than the studies of the variants.
I have one gene (ANO5) that has so many variants red lighted (as opposed to variations that are colored as not known to be an issue) that I havent even started to study what problems it causes.
This table doesn’t list all the issues with HQC yet because it is emerging data. They need more studies on Humans.
If a person notices pain relievers don’t work on them or on the flip side work too much they may have a genetic problem.
One Doctor thinks Elvis had a genetic problem with meds.
Oxy doesn’t work on me. That is why I get treated like a drug seeker even though it is verified in my file that I have genetic issues. I am putting off several surgeries until this issue is rectified.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.