Posted on 12/04/2024 2:22:14 PM PST by ConservativeMind
Scientists have discovered a key biological reason why obesity increases the risk of type 2 diabetes, and it boils down to size—specifically the size of fat cells.
While researchers have known that obesity disrupts the body's ability to make new fat cells, they haven't been able to pin down why. The findings shed new light on this link, establishing for the first time that obesity limits the body's ability to produce crucial cellular building blocks called ribosomal factors.
Without sufficient ribosomal factors, fat stem cells lack the machinery to differentiate to produce functioning fat cells. Instead, energy gets trapped and they become enlarged.
Fat tissue stores energy from food, but when it's not functioning properly, the excess energy is then rerouted to be stored elsewhere in the body like in the liver, causing fatty liver disease, or in the heart, leading to cardiovascular diseases like atherosclerosis or stroke.
When obese, diabetic mice—whose fat cells were four to five times larger than those found in lean mice—were given a drug called rosiglitazone, their ribosomal factors increased to normal levels, which triggered their fat stem cells to differentiate to produce new, smaller fat cells. The fat tissue, in turn, was then able to function properly in storing energy and generating key hormones that regulate metabolism.
"What's fascinating is that when given the drug, the mice remained obese, but their type 2 diabetes essentially disappeared," said Villanueva.
The findings suggest that enlarged fat cells impair fat tissue function and play a crucial role in diabetes development.
Rosiglitazone is currently being used to treat type 2 diabetes, but what hasn't been clear, until now, is what the drug is doing on a molecular level to improve glucose metabolism.
(Excerpt) Read more at medicalxpress.com ...
One existing drug already used by some with Type 2 diabetes, Rosiglitazone (Avandia), gives your body the ability to make the extra fat cells to normalize the fat load, getting rid of the five-fold “overstuffed, chronically-inflammed” fat cells. It gets rid of Type 2 diabetes (“type 2 diabetes essentially disappeared”) very quickly, but it does not address the root cause. Only you can do that.
As in all cases, what are the side effects and contraindications?
I see some potentially serious adverse effects and there is a long list of drug interactions.
Do your own homework before “trusting the science”.
A good start would be eating a lower car, real food diet and getting more exercise.
This is interesting to me because we’ve been told fat cells retain epigenetic memory of their fattest state and want to return to it.
So if this drug helps your body make new fat cells are the new ones pre-programmed to be large or could this drug help reset the old set point by creating new fat cells with a lower set point resulting in more permanent weight loss with less suffering from “food noise”.
I have watched a few of those long videos by doctors with new ways to fix things wrong with the body. One had to do with taking various supplements along with your morning coffee. This video spoke of converting your white fat cells to brown, smaller fat cells, which result in weight loss. I became very concerned in 2022 when 3 loved ones had cancer, and I was doing too much nervous nibbling. My BMI went up to 27.5 and my annual physical showed my Vitamin D level was INSUFfICIENT. RIght after that I say an article posted by Conservative Mind that said with a BMI above 25, Vitamin D goes into the fat rather than circulating int he blood where it helps immunity. Then I got real sick for 3 1/2 months, severe coughing and bronchitis. I upped my vitamin D3 consumption, followed a healthy low carb diet, eventually got better, and the next year’s annual physical showed a BMI of 23, and a bit too much blood vitamin D. My next annual physical is soon so I will see how my D level is this year. At any rate rather than weight near 160 lbs, my weight has varied between 130 and 140 lbs this year, and no illnesses.
“Only you can do that.”
Avandia plus GLP-1 drug?
“less suffering from “food noise”.”
What is it with the term “food noise”. Think I’ve heard or read it 3 times today. You mean literally... Digestive noises?
What happens to the old fat fat cells?
Do they slink away in shame?
Lol, I wish.
Obese people age more rapidly. Possibly because fat cells are not replacing themselves properly.
Are other cells also being inhibited from replacing themselves properly by obesity?
That it’s not just the wear and tear of weight and gravity, but systemic metabolic disruptions at the cellular level.
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