Enzymes linked to high-fat diet's impact on multiple sclerosis offer potential way to protect neurons (Palm Oil / Palmitic Acid)

Medical Xpress / CUNY Advanced Science Research Center / Glia ^ | Nov. 1, 2024 | Patrizia Casaccia et al

[ConservativeMind]

Research has identified crucial links between dietary choices and the progression of multiple sclerosis (MS).

The study, led by Patrizia Casaccia, explored how enzymes called ceramide synthase 5 and 6 are responsible for the toxic effect of a palm oil-rich diet on neurons in the central nervous system, which causes a subsequent increase in the severity of MS symptoms.

MS is an inflammatory autoimmune disease marked by extensive damage to the insulating myelin sheath that protects nerves throughout the body.

Using the experimental autoimmune encephalomyelitis (EAE) model of inflammatory demyelination, the research team found that diets high in palm oil led to a more severe disease course in mice.

"We reasoned that inside neuronal cells, palm oil is converted into a toxic substance called C16 ceramide by specific enzymes called CerS5 and CerS6," said Casaccia.

"This ceramide is responsible for inflicting mitochondrial damage, which deprives neurons of the energy they need to counteract inflammation in the brain."

The paper's findings have significant implications for individuals diagnosed with MS as well as for clinicians treating patients and neuroscientists researching the disease. The work reinforces that lifestyle choices, such as diet, can have a profound impact on the course of the disease.

The study's results build on previous concepts about careful dietary choices in managing the symptoms of MS. The findings also identify potential molecules that could help slow diet-induced symptom severity.

"Our research provides a molecular explanation for how to protect neurons from the palm-oil-dependent creation of molecules that harm them," said Casaccia.

"We hope this information can empower patients to make informed dietary decisions that could positively impact the course of the disease, while identifying strategies to counteract the effect of cerS5 and CerS6 in a neuron-specific fashion."

[ConservativeMind]

Staying away from palm oil and palmitic acid is your best way to address this method of worsening MS. Canola oil has a very small amount (3.6%), with coconut oil having just a little bit more (8.4%).

Palm oil is 45% palmitic acid.

[ConservativeMind]

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[miniTAX]

Model, on mice, a propsosed mecanism that may...
Science! yeah sure.

[Blue Highway]

How about olive oil and avocado oil?

[Flaming Conservative]

Palm oil is in most breads, cakes, cookies and other baked goods.

[logi_cal869]

Palm oil is toxic and should be classed with seed oils (such as RAPEseed, brand name ‘canola’).

Good luck with that.

[AdmSmith]

Thanks, here is the article

Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis

https://pubmed.ncbi.nlm.nih.gov/39489703/

However, in biology it is both positive and negative:

Roles and therapeutic targeting of ceramide metabolism in cancer.

“Research on C16-Ceramide spans multiple cancer types, including cell line-based in vitro studies for androgen-sensitive prostate cancer, underscoring its potential efficacy for treating prostate cancer with implications for other cancer types”

https://pmc.ncbi.nlm.nih.gov/articles/PMC11031839/

[ptsal]

not mine....home baker