Mouse study finds increasing cardiac ketones may help treat heart failure

Medical Xpress / American Heart Association / Basic Cardiovascular Sciences Scientific Sessions 2024 ^ | July 24, 2024 | Qiuyu (Violet) Sun, B.Sc. et al

[ConservativeMind]

Increasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary research.

Heart failure with preserved ejection fraction, a common type of heart failure, occurs when there are signs and symptoms of heart failure with a high left ventricle filling pressure despite normal or a near-normal left ventricle ejection fraction of 50% or higher. Heart failure with reduced ejection fraction is when the heart's pumping power is 40% or less.

Healthy hearts require a high rate of adenosine triphosphate (ATP) production (provides the energy to drive and support the heart) to maintain their continuous pumping action.

"Humans normally rely on carbohydrates and fat for energy. However, when blood glucose levels fall, it poses a risk to our brain, which depends on glucose and cannot utilize fats for energy. To address this, our body has a built-in mechanism to produce this special energy substrate called ketones."

In this study, researchers assessed mice hearts' metabolism and found that hearts with HFpEF reconstructed their metabolic profiles. Specifically, the researchers found in HFpEF hearts, ketone use was impaired, as well was also an impaired glucose oxidation rate coupled with an increase in fatty acid oxidation.

When HFpEF hearts were given more ketones, this resulted in an increase in overall ATP production coming from ketones and glucose oxidation to ATP from 15% to 28% with preserved pumping ability. So, increasing ketone supply to the heart in HFpEF mice led to higher ATP production.

"This is crucial because this increase in ketone use by the heart did not cause any interference with glucose or fat use. As such, elevated ketone oxidation does not further aggravate the disrupted metabolic profile of the heart in HFpEF," Sun said. said.

[ConservativeMind]

Having more ketones helped heart failure with preserved ejection fraction because the metabolism of the affected cells changed to prefer ketones.

You can buy ketone supplements or consider a Ketogenic diet, to get more ketones.

[ConservativeMind]

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[AlmaKing]

Seems like yet another reason to cut sugar.

[DannyTN]

These creatures you call mice, you see, they are not quite as they appear. They are merely the protrusion into our dimension of vastly hyperintelligent pandimensional beings.

Douglas Adams

[redfreedom]

So mice have been studying thus, huh? Interesting.

[Coleus]

Thanks for posting 📫 ☺️