Posted on 06/23/2024 8:47:56 PM PDT by ConservativeMind
Changing the way antibiotics are given to adult patients with sepsis will save thousands of lives a year globally, according to research.
A clinical trial and systematic review have shown that intravenously administering commonly used penicillin-like antibiotics via continuous infusion—instead of multiple short infusions—cures infections and saves lives.
The clinical trial of more than 7,000 patients tested findings from laboratory studies to deliver the best drug concentration for the bacteria causing the infection.
"We found by delivering these antibiotic doses as a continuous infusion we can maintain the concentration of the antibiotic in a patient's blood and tissue, and kill bacteria at a greater rate," Professor Roberts said.
"This simple intervention uses commonly available antibiotics, so even small hospitals in third-world countries can implement the dosing change."
"The trial was a massive undertaking involving 104 hospitals in 7 countries, more than 130,000 doses of medication and the analysis of 4 million data points," Dr. Dulhunty said.
Associate Professor Naomi Hammond said the clinical trial data was then used in a systematic review and meta-analysis, combining 18 studies and more than 9,000 patients.
"The combined data showed a very significant benefit with the use of a continuous infusion, saving one life for every 26 patients treated," Dr. Hammond said.
Professor Jeffrey Lipman said the next step for the research team would be to inform worldwide treatment protocols and guidelines.
"Physicians follow international guidelines when treating sepsis patients, and at the moment these guidelines have a very low certainty of evidence around how to best administer these drugs," Emeritus Professor Lipman said. "Thanks to our program of research, treatment protocols and guidelines will now have a very high certainty. Given the simple nature of the findings and the conversations we are having between hospitals, we expect most will adopt these changes immediately."
(Excerpt) Read more at medicalxpress.com ...
Treating the sepsis patient with vitamin C helps a lot.
what is the primary cause of sepsis?
Seems like Ivermectin would mitigate sepsis.
“Treating the sepsis patient with vitamin C helps a lot.”
More than a treatment, it seems it’s a cure. I had a Vitamin C drip before I underwent surgery. Post surgery the number one thing they’re concerned about is one’s body temperature, i.e., infection.
Maybe someone should start asking why so many people are contracting sepsis.
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That was my first thought...IVs of Vitamin C
https://my.clevelandclinic.org › health › diseases › 12361-sepsis
Sepsis: Symptoms, Causes, Treatment & Prevention - Cleveland Clinic
Jan 19, 2023Sepsis occurs when your immune system has a dangerous reaction to an infection. It causes extensive inflammation throughout your body that can lead to tissue damage, organ failure
“The trial was a massive undertaking involving 104 hospitals in 7 countries, more than 130,000 doses of medication and the analysis of 4 million data points,” Dr. Dulhunty said.
More testing/trials than they had for the clot shot. What a surprise! Not. :(
Had sepsis and pneumonia at Christmas. Almost kicked the 🪣.
Lost most of my hair and am still recovering.
I have Post Sepsis Syndrome.
The first time it was tried and subsequently made news it rather shocked the medical establishment.
What happens after the bacteria mutates?
There are multiple roads to Sepsis, usually an infection of some kind or another. For me it was gangrene.
Four year survivor, many post Sepsis issues but here I am.
👍
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