Study finds antioxidant dietary supplement may help counter systemic sclerosis

Medical Xpress / Louis Pasteur Ctr for Med Research / International Journal of Molecular Sciences ^ | May 17, 2024 | Fukka You et al

[ConservativeMind]

Autoimmune diseases occur when the body's immune system attacks healthy cells instead of protecting them. Systemic sclerosis (SSc) is one such autoimmune condition characterized by faulty circulatory and immune systems, leading to the occurrence of fibrosis (hardening and scarring of healthy tissue) of the skin and internal organs.

Countering oxidative stress using antioxidant compounds, is therefore, being increasingly explored as a therapeutic strategy.

To this end, a team of researchers has investigated the effectiveness of Twendee X (TwX)—a dietary supplement comprising of a combination of eight active antioxidants—in reducing oxidative stress in SSc mouse models.

Prof. Inufusa says, "Studies have shown that TwX reduces ROS, protects mitochondrial function, and improves cognition and memory."

The eight constituents of TwX include vitamin C, L-glutamine, niacin, L-cystine, coenzyme Q10, vitamin B2, succinic acid, and fumaric acid. The combined antioxidant effect is likely more potent than the activity of either compound alone. Previous studies have demonstrated improvement in cognition, memory, and motor coordination in mouse models of dementia, and reduction in affected region size, oxidative stress, and inflammation in mouse models of ischemic stroke following treatment with TwX.

Based on these findings, the researchers conducted this study to investigate the effects of TwX in a mouse model of SSc created using hypochlorous acid (HOCl).

HOCl induction led to a significant increase in the serum levels of advanced oxidation protein products (AOPP), mimicking SSc-like features.

Notably, the AOPP levels of mice treated with TwX were substantially lower than that of the healthy animals. Moreover, TwX treatment significantly reduced skin thickness, accumulation of the collagen protein, skin levels of hydroxyproline—an oxidative stress marker, and fibrosis of the skin and lungs.

Overall, these results suggest that TwX may treat SSc by regulating oxidative stress, and reducing skin and lung fibrosis.

[ConservativeMind]

Twendee X is a supplement that contains “Vitamin C, L-glutamine, niacin, L-cystine, coenzyme Q10, vitamin B2, succinic acid, and fumaric acid.” It is available at places like Amazon, but the constituents are easy to find and use.

This supplement has been found to be helpful for “ cognition, memory, and motor coordination in mouse models of dementia, and reduction in affected region size, oxidative stress, and inflammation in mouse models of ischemic stroke,” as well.

[ConservativeMind]

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[laplata]

Please add me to your ping list. Thank you.

[Oystir]

Is this Japanese? If so, I may have heard of it.

[misanthrope]

Bookmark

[Carriage Hill]

Just ordered 2 bottles from Amazon:

https://www.amazon.com/gp/product/B0B8MGH2S1/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1

[AuntB]

Aka scleroderma, which I have had 50 years.
Sorry, I don’t believe this. More false hope nonsense

[goodnesswins]

I wonder HOW MUCH of each supplement is in each tablet. Does not reveal ingredient list like most do.