Posted on 03/30/2024 7:24:56 AM PDT by ConservativeMind
Using patient data from six major U.S. cancer centers, researchers developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, first generalizable study of its kind
Cisplatin is a highly effective chemotherapy that has been used to treat cancer for decades, but it can cause kidney injury that can potentially lead to the discontinuation of life-saving cancer treatments. Investigators developed a comprehensive tool to predict which patients are at highest risk of moderate-to-severe kidney injury after cisplatin.
They found the highest-risk patients had as much as a 20-fold higher risk of developing kidney injury after cisplatin than those in the lowest-risk group.
The researchers examined data from over 24,000 patients across six major U.S. cancer centers and analyzed the risk of moderate-to-severe acute kidney injury within the first 14 days following a single, first IV dose of cisplatin.
The model developed by the research team included several important risk factors for kidney injury, including age, high blood pressure, diabetes, laboratory findings from routinely available bloodwork, and higher doses of cisplatin. They found that patients who developed kidney injury from cisplatin had a considerably higher risk of death compared to those who did not.
Another key finding was that lower levels of magnesium were an important risk factor for acute kidney injury. The researchers plan to use the same rich database to try to identify therapies that might prevent kidney injury, including magnesium.
Using the risk score, the research team created a simple online calculator that will be made available for use at MDCalc.com. A patient or physician can use this calculator to quantify the risk of kidney injury by inputting information, including whether the patient has high blood pressure, diabetes, or other diseases or medical conditions, along with results from their bloodwork.
(Excerpt) Read more at medicalxpress.com ...
The acute kidney injury risk was up to 20X worse with such factors.
The website the cisplatin kidney risk calculator will be available is MDCalc.com.
My kidneys are barely hanging on. I had cisplatin in 2013.
I too have permanent kidney damage from cisplatin. I lost about half my kidney function. Between 3 rounds of chemo and 35 radiation treatments, life was pretty miserable for about 6 months. But on the bright side, I’m alive and apparently cancer free after a year.
I start a new treatment on Monday. It involves a radioactive implant in my right lung. After that, if you stand next to me, you might feel the aura.
Very interesting and we didn’t know this - weren’t told this.
My husband had two rounds of cisplatin for bile duct cancer - not too much later, I rushed him to the ER where the doctors told me he was in complete kidney failure. Fortunately, his kidneys recovered (we were told) - but by then, the bile duct cancer was too far advanced and he succumbed.
Hang in there. The people I know who have done the radiation only did pretty well. They said after a week or two, they felt tired. But other then that they did alright and all are in remission. Barbaric as the treatments are, they seem to work amazingly well.
I went through six weeks of daily radiation and chemo last spring. They appeared to work, but it looks like the cancer came right back.
This is what happened to me. After my first round of chemo, I went into almost complete kidney failure and almost died. My wife got me right to ER and into ICU where they saved my life after a couple of rounds of dialysis. Now my kidney is completely functional, but it was pretty scary at the time, and I had to have rehab and PT just because of the extended hospital stay. My oncologist tells me the bad reaction I had was due to an uncommon genetic predisposition to react against that part of the treatment. I wonder if that is a factor in the above study.
You may want to just make sure you stay healthy now, as you can, and do get enough magnesium, which I’ve read 70% of Americans are deficient in.
Also, consider following up on a study from yesterday:
https://freerepublic.com/focus/f-chat/4227786/posts
Thanks
Good luck, I hope it works out for you.
You can increase your eGFR.
Look through these threads:
https://freerepublic.com/tag/egfr/index?tab=articles
Is there an immunotherapy available?
I tried immunotherapy last summer for three infusions. It didn’t mesh with my body chemistry. I had most of the known side effects.
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