Malfunctioning mitochondria at the heart of many cardiovascular diseases

Medical Xpress / Sbarro Health Research Organization (SHRO) / Intl Journal of Molecular Sciences ^ | Jan. 24, 2023 | Giovanni Ciccarelli et al

[ConservativeMind]

Many cardiovascular diseases, such as atherosclerosis, or "hardening of the arteries," correlate to mitochondrial dysfunction and endothelial impairment in the tissues of the heart and blood vessels. Despite a significant improvement in therapies to treat cardiovascular disease, there is an unmet need to investigate mitochondria as a therapeutic target.

A review published recently in the International Journal of Molecular Sciences explores the existing literature on relevant studies and makes recommendations for further study.

The authors of the paper propose a closer examination of this relationship between mitochondrial dysfunction, endothelial impairment, and atherosclerosis is necessary in order to identify new precision medicine targets to better regulate mitochondrial functioning in patients with these conditions.

Malfunctioning mitochondria causes endothelial dysfunction due to a molecule called a reactive oxygen species (ROS), or "free radicals," which are produced by the dysfunctional mitochondria. The increase in ROS then leads to oxidative stress, inflammation, and a buildup of cholesterol and lipids, forming atherosclerotic plaque in the blood vessels.

The modulation of mitochondrial function through precision medicine could delay the development of this endothelial dysfunction.

Although mitochondria have been recognized as a new therapeutic target in different pathological contexts, no clinical or preclinical studies have been designed on atherosclerosis.

Both antioxidants and gene therapy are attractive approaches for the treatment of atherosclerosis, however, further studies are needed.

The authors hope to start new clinical or preclinical trials to explore the effect of mitochondrial modulation on development of atherosclerotic plaque, in order to evaluate if this kind of therapeutic intervention could lead to a significant reduction of residual risk related to ischemic cardiovascular disease.

[ConservativeMind]

The paper mentions nicotinamide riboside and MitoQ, but does not appear to mention other mitophagy activators like urolithin A, nor does it mention a better mitochondrial protector than MitoQ, ergotheineine, which comes from mushrooms. It also doesn’t mention GlyNAC or taurine, which help make glutathione and superoxide dismutase, which help protect mitochondria and the rest of the cells.

That said, knowing mitochondrial dysfunction is behind cardiovascular disease allows these therapeutic approaches to help heal a critical problem in a great many people.

Note that basically all of the substances mentioned above have been posted as prior study articles and are available via the search function.

[ConservativeMind]

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[Disambiguator]

Malfunctioning Mitochondria

🤔

Band name?

[EEGator]

Odd, my second Art DeVany reference in one evening.
I hadn’t referenced him in...I can’t remember when...

https://deuteroelastose16.rssing.com/chan-9065031/all_p2.html

[EEGator]

Maybe Cellular Apoptosis.

Adenosine Triphosphate & the Synapses...

[Secret Agent Man]

Co-q10 can help cellular mitochondria repair and work better. Most people, especially as they get older, hve less coq10 in their cells, but they need the most in their heart and cardio tissues. Its really vital for good heart/cardio health.

[Ezekiel]

Lol, you kids are on a roll.

[EEGator]

“A moment of clarity”.

[logi_cal869]

Malfunctioning mitochondria causes endothelial dysfunction due to a molecule called a reactive oxygen species (ROS), or "free radicals," which are produced by the dysfunctional mitochondria. The increase in ROS then leads to oxidative stress, inflammation, and a buildup of cholesterol and lipids, forming atherosclerotic plaque in the blood vessels.

Horse hockey. Unbelievable ignorance, but I'm sure it cements grants for the authors. I have a million dollar bet that they'll not figure out CVD in my lifetime: There's too much money in treatment to resolve the cause...besides the fact that a sick population is malleable (it will get much, much worse post-jabs).

[Ezekiel]

I wonder if Mitochondrion and the Organelles is already taken.

🤓

[EEGator]

I say you have a claim to it. :)

Tons of Biology band names to be had...

[Adder]

The Organelles was that 50’s girl group. “Johnnie Kiss Me Behind The Cell Walls”

Gave it a 73 because I could dance to it.

[Dave Wright]

One of the most exciting non-invasive, non-drug therapies that targets mitochondria function is photobiomodulation or PBM. Serveral peer reviewed studies have shown the using specific wavelengths of near-infra-red (NIR) light from LEDs held against the skin penetrate into tissues and reduce oxidative stress (ROS) in the mitochondria. This was used to treat hospitalized COVID patients and reduced their days in the hospital and serious effects including death over placebo treatments. It has also been used to slow cognitive decline in Alzheimer’s and Parkinson’s disease.

Here’s a video that discusses some of the science behind this.
https://youtu.be/a_8rE-71Y48?t=1046

[aMorePerfectUnion]

I’ll throw methylene blue into the mix

[Ezekiel]

“Johnnie Kiss Me Behind The Cell Walls”

You've got to move fast around here.

The hot songs are already hitting the charts.

Didn't the Osmotics do a cover of that one?

[RummyChick]

https://mitoredlight.com/collections

[brianr10]

Golgi Apparatus