Posted on 11/22/2022 10:50:41 AM PST by ConservativeMind
A dietary change could be a key to enhancing colon cancer treatment, a study finds.
Cancer cells need nutrients to survive and grow. One of the most important nutrient sensing molecules in a cell is called mTORC1. Often called a master regulator of cell growth, it allows cells to sense different nutrients and thereby grow and proliferate. When nutrients are limited, cells dial down nutrient sensing cascade and turn off mTORC1.
"In colon cancer, when you decrease the nutrients available in the tumors, the cells don't know what to do. Without the nutrients to grow, they undergo a kind of crisis, which leads to massive cell death," said Yatrik M. Shah, Ph.D.
Researchers found in cells and in mice that a low-protein diet blocked the nutrient signaling pathway that fires up a master regulator of cancer growth.
The regulator, mTORC1, controls how cells use nutritional signals to grow and multiply. It's highly active in cancers with certain mutations and is known to cause cancer to become resistant to standard treatments. A low-protein diet, and specifically a reduction in two key amino acids, changed the nutritional signals through a complex called GATOR.
Previous efforts to block mTORC have focused on inhibiting its cancer-causing signals. But these inhibitors cause significant side effects—and when patients stop taking it, the cancer comes back. The study suggests that blocking the nutrient pathway by limiting amino acids through a low-protein diet offers an alternative way to shut down mTORC.
"A low-protein diet won't be standalone treatment. It has to be combined with something else, such as chemotherapy," Solanki said.
The risk with a low-protein diet is that people with cancer often experience muscle weakness and weight loss, which limiting protein could exasperate.
"Putting cancer patients on a protein-deficient diet long-term is not ideal," Shah said.
(Excerpt) Read more at medicalxpress.com ...
Doc said that likely helped starve the cancer.
"Dietary change" went from a 'cup-of-soup'/day down to nothing/day for the last week. (so, the specific amino acids didn't matter)
“The risk with a low-protein diet is that people with cancer often experience muscle weakness and weight loss, which limiting protein could exasperate.”
Exacerbate.
bttt ob
Exasperate? Yes, I'm sure the mTORC cells are quite exasperated by a low protein diet.
Or, did the author mean "exacerbate" but failed his latest vocabulary test?
Well, each of the Three Stooges would order burnt toast and a rotten egg when he had a tapeworm.
I didn’t do it...
bone broth is a good nutritious thing when one can’t eat due to chemo or whatever- even good to have while fasting from solid foods-
lol
no matter what the issue is
less meat and less crude oil is always the default answer you can expect.
Read my tagline please. Regular aerobic Exercise is very beneficial in starving cancer cells since exercise lowers blood sugar and cancer cells like sugar better than anything else.
Before a PET scan, my spouse is given a sugary drink. Then the scan is done which lights up all the cancer locations.
LOLOL!
“Before a PET scan, my spouse is given a sugary drink. Then the scan is done which lights up all the cancer locations.”
I have been wondering how well a Keto diet would do.
Check out Dr. Berg, and others, on YouTube.
They all would say that,
1) Sugar is what feeds cancer
2) Keto is a very low-sugar diet
3) Therefore, a keto diet would benefit a patient diagnosed with cancer (or diabetes, or heart disease, etc.)
I missed your first post. This answered my question as to whether low protein would hurt patient.
I had colon cancer in 1996. My main side effect from chemo and radiation was severe diarrhea. The only food I could begin to hold in was rice soaked with chicken broth. I lost about 40 pounds over the 7 week period of diarrhea.
After the end of the diarrheal period, and after the internal radiation burns healed up, my doc said I needed to gain weight. That was not a problem at all, because I was always hungry and everything tasted wonderful. After 3 months I had gained all the weight back, and then some.
This has been known for a long, long time.
1. cut sugar
2. oxygenate the body
3. nutrify the body (selenium)
4. shove coffee up your butt (medium roast seems to work best for an enema)
The treatment was in the neck so my taste buds were racked and I couldn’t detect sweet for 3 months, which reduces the enthusiasm, but I managed to get back in shape and climbed a 14er several month latter.
Looks like leucine and arginine are the two AA’s.
I seem to recall something about something anabolic activated by arginine was reversed by lysine, can’t recall the details.
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-020-00679-2
Good catch on the likely amino acids!
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