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One-off treatment shown to prevent long term side effects of cancer radiotherapies (Senolytics prevented long term issues by eliminating defective cells from treatment, preventing premature aging)
Medical Xpress / Newcastle University / eLife ^ | May 23, 2022 | Edward Fielder et al

Posted on 05/23/2022 7:01:08 PM PDT by ConservativeMind

A new study has found that a simple, one-off treatment was able to prevent long term side effects of cancer radiotherapies.

There are about 2 million cancer survivors in the UK, and many face premature memory loss and faster occurrence of various diseases resembling premature aging, to which sadly, there is no cure. This is thought to be caused by side effects of toxic cancer chemotherapies and radiotherapies, which aim to treat cancer cells but can also damage normal cells.

The researchers wanted to know whether they could prevent such devastating consequences of cancer therapies by a short treatment with senolytics, a class of drugs that specifically eliminate damaged cells due to cancer therapies and tested the idea in mice.

They found that the animals treated with senolytic drugs soon after radiotherapy did not develop premature aging, and the animals treated after they started suffering from premature aging also show improved health conditions subsequently.

Dr. Satomi Miwa, Lecturer says that "increasing numbers of people are now successfully treated from cancer, and the survival rates from many cancer types are high. The people who had beaten cancers can start looking forward to their new lives again—but only if the quality of life is not going to be affected. Our new research shows that there is a way to prevent any long-term side effects occurring, and to reduce risks of cancer relapse."

Senolytics are an exciting development in the biology of aging as the drugs kill senescent cells by targeting their survival mechanisms which are absent in normal cells. They have been shown to postpone or in some cases, heal age-associated disease or disability in mice.

Currently, a dozen clinical trials using different senolytic drugs in humans are underway against such conditions as pulmonary fibrosis (lung fibrosis), diabetic kidney disease and osteoarthritis.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS:
Over the counter senolytic supplements include quercetin, fisetin, Piperlongumine. I take, or have taken quercetin and fisetin. It is my understanding fisetin is a better choice.
1 posted on 05/23/2022 7:01:08 PM PDT by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Now keeping a new list (“Common/Top Issues”) for conditions expected to only concern at least 1% of the population. Ask to be on either the “Common/Top Issues” or “Everything” list.

Please email or private message me if you want on or off of a list and of which list you desire.

2 posted on 05/23/2022 7:02:07 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Life extension has senolytic activator


3 posted on 05/23/2022 7:08:18 PM PDT by RummyChick
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To: ConservativeMind

Quercetin.

I take.

Bromelain on empty stomach can do much the same as. Some people tolerate one better than the other. I can take either.

A good combo is NAC and Glycine.


4 posted on 05/23/2022 7:09:30 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: ConservativeMind

Ping


5 posted on 05/23/2022 7:44:34 PM PDT by WhattheDickens? (Funny, I didn’t think this was 1984…)
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To: Whenifhow; null and void; aragorn; EnigmaticAnomaly; kalee; Kale; AZ .44 MAG; Baynative; bgill; ...

p


6 posted on 05/23/2022 7:47:10 PM PDT by bitt ( <img src=' 'width=50%> )
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To: Secret Agent Man; ConservativeMind

>>A good combo is NAC and Glycine

There was an article posted on that by ConservateMind in the last week or so.

My order should show up any day now.


7 posted on 05/23/2022 7:48:57 PM PDT by FreedomPoster (Islam delenda est)
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To: ConservativeMind

One of the benefits of going to thorium liquid fueled breeder reactors is the ability to chemically extract the radioactive byproducts without shutting down the reactor. These elements are very short-lived alpha emitters that can be chemically bound to guide RNA capsids. The RNA is designed to only attach to specific structures presented on the outside of cancer cells and not normal cells.

The alpha emitters are very heavy (helium nuclei) and therefore only travel to the closest cancer cells before their energy is absorbed killing the cell. There are no side effects as there are with gamma radiation or chemotherapy.

Currently these isotopes are only made in one special target reactor in Denmark and flown around the world at great cost. Using a breeder reactor would make these therapies available for a fraction of the cost saving many more lives.

These reactors need U233 to get started until they create their own fissile thorium isotopes. The US has a stockpile of about 800 kg of U233 at the Oak Ridge National Laboratory that was refined for use in the nuclear weapons programs at a cost of billions. Stupidly, the stockpile is being destroyed by mixing it with U238 as part of a Russian disarmament treaty that the Russians are already violating.

We are literally destroying the seeds that could provide unlimited thorium nuclear energy for thousands of years and cure many tumor cancers in the bargain to satisfy a worthless treaty with Russia.


8 posted on 05/23/2022 8:29:13 PM PDT by Dave Wright
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To: bitt

What is bringing all this up of a sudden?


9 posted on 05/23/2022 8:32:07 PM PDT by Bob Ireland (The Democrap Party is the enemy of freedom.They use all the seductions and deceits of the Bolshevics)
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To: ConservativeMind

My beloved PTSD dog who has osteosarcoma had stereotactic radiation and I have Quercetin.
Should I start giving it to him?
Will that interfere with his chemo and zolendrate infusions?
I’ll do anything that has any chance of making him one of the Lucky Ones.


10 posted on 05/24/2022 12:59:14 AM PDT by Salamander (Please visit my profile page help save my beloved dog's life. https://www.givesendgo.com/G2FUF)
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To: ConservativeMind

?

https://www.greatpetcare.com/wellness/quercetin-for-dogs-uses-and-benefits/


11 posted on 05/24/2022 1:01:23 AM PDT by Salamander (Please visit my profile page help save my beloved dog's life. https://www.givesendgo.com/G2FUF)
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To: Salamander

Since your dog is on medicine, I would ask your vet.


12 posted on 05/24/2022 3:29:57 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Two of the senolytic supplements (not drugs) that I know of are apigenin and fisetin. Swanson has both cheap.


13 posted on 05/24/2022 8:34:32 AM PDT by matthew fuller (Donald J. Trump—the 45th, and last legitimate President of the United States.)
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