Posted on 05/23/2022 6:45:23 PM PDT by ConservativeMind
For patients receiving concurrent chemoradiotherapy for squamous cell carcinoma of the head and neck, higher doses of gabapentin are well tolerated and associated with delayed time to first opioid use for additional pain control during radiotherapy (RT), according to a research letter published online May 18 in JAMA Network Open.
Sung Jun Ma, M.D., from the Roswell Park Comprehensive Cancer Center in Buffalo, New York, and colleagues performed a secondary analysis of two clinical trials involving 92 patients receiving concurrent chemoradiotherapy for nonmetastatic squamous cell carcinoma of the head and neck and prophylactic oral gabapentin (titrated to 900 mg versus 2,700 mg daily in one study and 3,600 mg daily in the other study).
The researchers found that most patients tolerated gabapentin per protocol. The time to first opioid use for additional pain control was greatest in the 3,600-mg cohort in the multivariable competing risks model. The smallest proportion of patients requiring opioids during RT was seen in the 3,600-mg cohort compared with the 900-mg and 2,700-mg cohorts (37.5, 93.1, and 61.3 percent, respectively). Compared with the 3,600-mg cohort, the odds of feeding tube placement were significantly greater during RT in the 2,700-mg cohort; the odds were not significantly greater in the 900-mg cohort.
"Although gabapentin, 3,600 mg, daily has been adopted as the standard regimen of the Roswell Park Comprehensive Cancer Center, additional studies are warranted to further investigate its role in pain control," the authors write.
(Excerpt) Read more at medicalxpress.com ...
I take Gabapentin for hip pain and it’s very effective but makes me sleepy.
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I needed back surgery to trim the protrusion on a ruptured L4/L5 disc - which was impinging on a nerve bundle and giving me excruciating sciatica. I mean disabling pain. A neurological surgeon who ultimately fixed the problem recommended Gabapentin and it worked in the month before surgery, attenuating the pain by 95%. I think I was using 3 300mg capsules a day. I stopped the day before surgery and never used it again, as the surgery was the perfect solution. In my experience Gabapentin is an impressive and effective pharmaceutical.
Gabepentin gives quite a bit of brain fog.
I was on Gabapentin for a brief time, until the insurance finally approved Lyrica.
I was on Lyrica for a year and a half. Still have nerve problems.
Mucositis is a big problem as it is painful to eat. Super important to eat during cancer combat.
And mixing gabapentin and opioids is a thing:
Stunning. The 987,340th example of people abusing a product that is created for a legitimate purpose, and accomplishes that pretty well. I am sick of people who abuse drugs to get high and end up making life more difficult for people who have legitimate need for pharmaceuticals in their intended application.
Would like to read document.
“does not exist on this server”
https://www.sciencedirect.com/science/article/abs/pii/S0901502710003474
My neurologist told me to take it at night because of that side effect.
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