Posted on 05/17/2022 7:53:57 PM PDT by ConservativeMind
A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione—could improve many age-associated defects in older humans.
The results of this study show that older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. The benefits declined after stopping supplementation for 12 weeks. GlyNAC supplementation was well tolerated during the study period.
Animal studies conducted in the Sekhar lab have shown that restoring glutathione levels by providing GlyNAC reverses glutathione deficiency, reduces oxidative stress and fully restores mitochondrial function in aged mice.
"We worked with eight older adults 70 to 80 years of age, comparing them with gender-matched younger adults between 21 and 30 years old," Sekhar said. "We measured glutathione in red-blood cells, mitochondrial fuel-oxidation, plasma biomarkers of oxidative stress and oxidant damage, inflammation, endothelial function, glucose and insulin, gait-speed, muscle strength, exercise capacity, cognitive tests, gene-damage, glucose-production and muscle-protein breakdown rates and body composition. Before taking GlyNAC, all these measurements were abnormal in older adults when compared with those in younger people."
The older participants took GlyNAC for 24 weeks, and then stopped it for 12 weeks.
"We are very excited by the results," Sekhar said. "After taking GlyNAC for 24 weeks, all these defects in older adults improved and some reversed to the levels found in young adults." The researchers also determined that older adults tolerated GlyNAC well for 24 weeks. The benefits, however, declined after stopping GlyNAC supplementation for 12 weeks.
(Excerpt) Read more at medicalxpress.com ...
It looks like 1/8th of the atoms in the molecule are sulphur, if I read this correct:
https://en.m.wikipedia.org/wiki/Acetylcysteine
I also have some information on that study from my prior thread on it:
GlyNAC supplementation extends life span in mice (Equal parts glycine and NAC)
https://freerepublic.com/focus/f-chat/4044707/posts
yeah i,m not sure how much it woudl take to cause health issues,- i do know some folks are really allergic to sulfur though-
Thanks for the info. I’m going to give this a try.
think there is a precaution for one or the other of them if a person has allergies to sulfur-
I was wondering about that; I’m allergic to sulfa. Any chemistry experts out there know?
I’m no expert (on anything) but sometimes it’s the form of sulfur that is the problem. This explains it here.
I have heard that a diet of ruminant animal meat, such as beef, eggs, liver, bacon, grass fed butter and little else gives you similar benefits — weight loss, reduced insulin levels, reduced inflammation, cognitive improvements.
Those foods supply plenty of amino acids and if other foods aren’t consumed perhaps the body can concentrate its efforts on the production of glutathione.
In any case, I thought it was interesting that there seems to be a reason that this particular diet and these amino acid supplements give such a similar result.
Setria has been around a long time and is proven effective. More expensive though. I used to buy it from the guy who patented the formulation, Dr Harry Demopoulos.
Squat for knee pain, deadlift for back pain.
“but pure oral glutathione will be digested in the gut”
True. This has been known since the ‘30s.
Dr Harry Demopoulos patented a formulation that strategically added a sulfur molecule which enabled glutathione to be successfully absorbed. You can still get that formulation from the brand name Setria.
Thank you!
Yes, you did post it already, but it’s good enough to post again. I actually bookmarked your first posting of it just yesterday.
I’ve been raking NAC since the start of the pandemic when I learned about it from Dr. Roger Seheult’s “COVID Update” daily video series on YouTube.
I have noticed significantly reduced phlegm and clearer lungs as well as a complete avoidance of respiratory infections. I will have to add the glycine.
“I’d give it at least a half hour.”
I’m not sure what you are saying.
Bob was making a joke.
do you take NAC morning or evenings?
Is the sulpher in the NAC of the same type as sulpheraphane. That is, do they do the same thing. Such that if you take NAC you don’t need to take sulpheraphane?
The human liver absorbs oral glutathione before it gets to bloodstream.So they studied precursors which means metabolic manufacturing after liver passes.
tku-good report
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