Posted on 03/03/2022 9:43:07 PM PST by ConservativeMind
Many people have to take statins to lower their cholesterol levels. But statins may be able to do more: Researchers report that these drugs inhibit a gene that promotes cancer metastasis.
Cancer patients rarely die from the primary tumor but rather from the metastases.
Professor Ulrike Stein and her lab were able to discover an important driver of this process in human colorectal cancer: the metastasis-associated in colon cancer 1 (MACC1) gene.
When cancer cells express MACC1, their ability to proliferate, move around the body, and invade other tissues is enhanced. "Many types of cancers spread only in patients with high MACC1 expression," Stein explains. MACC1's role as a key factor and biomarker of tumor growth and metastasis -- not only in colorectal cancer, but in more than 20 solid tumors such as gastric, liver and breast cancer -- has since been studied by many other researchers. Stein has discovered what could disrupt metastatic progression in such cases: Statins, which are prescribed as cholesterol-lowering drugs, inhibit MACC1 expression in tumor cells.
In their search for MACC1 inhibitors, the researchers conducted high-throughput drug screening. They independently hit upon statins. They tested this discovery on various tumor cell lines, with favorable results: All seven drugs tested reduced MACC1 expression in the cells but to varying degrees. The scientists then administered the cholesterol inhibitors to genetically modified mice with increased MACC1 expression. This almost completely suppressed the formation of tumors and metastases in the animals. "What is particularly remarkable is that the benefits continued in the animals even after we reduced the dose relative to the amount that humans normally ingest," Stein says.
Robert Preißner examined 300,000 patients prescribed statins. This analysis found a correlation: "Patients taking statins had only half the incidence of cancer compared to the general population," Preißner explains.
(Excerpt) Read more at sciencedaily.com ...
Atorvastatin (Lipitor) was best, followed in no particular order by fluvastatin (Lescol), pravastatin (Pravachol), and rosuvastatin (Crestor). Simvastatin (Zocor) had the lowest benefit.
Notably, statin intake correlated with a significant reduction in cancer incidence (odds ratio [OR], .72; 95% confidence interval [CI], .70–.74). For statin-taking patients, we calculated a higher cancer survival probability versus subjects not taking any statins (Cox proportional-hazards model; hazards ratio [HR], .64; 95% CI, .48–.86). We found no difference for low-dose (20 mg: HR, 1.1; 95% CI, 0.89–1.37) versus high-dose (80 mg: HR, 1.11; 95% CI, .83–1.48) treatments; similarly, low-dose (10–20 mg: HR, .80; 95% CI, .59–1.09) and high-dose atorvastatin regimes (80 mg: HR, .72; 95% CI, .51–1.02) were comparable. When considering each statin separately, we found a strong cancer-preventive effect for atorvastatin (OR, .41; 95% CI, .38–.43) and significant effects for fluvastatin (OR, .7; 95% CI, .57–.85), pravastatin (OR, .63; 95% CI, .56–.71) and rosuvastatin (OR, .43; 95% CI, .36–.51); simvastatin showed only a weak cancer-preventive effect (OR, .9; 95% CI, .87–.94), and lovastatin effects were not readily assessed (relatively few patients; broad confidence intervals; Table S2).
We also considered the clinical data as a 1:1 matched-study design, using propensity score-matched sub-cohorts to better control for confounding associations that might stem from different distributions of age and gender between the whole dataset and the subset of cancer patients. We discovered further evidence supporting the cancer-preventive effect of statins (Figure 4 and Figure S4): (i) all statins considered together had an OR of .5 (95% CI, .48–.51), with (ii) atorvastatin .30 (95% CI, .28–.32), fluvastatin .65 (95% CI, .47–.88), lovastatin .51 (95% CI, .38–.7), pravastatin .47 (95% CI, .42–.54), rosuvastatin .32 (95% CI, .26–.38), and simvastatin .63 (95% CI, .61–.66).
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...except, of course, for the side-effects.
Statins do more harm than good.
For later
By design per Rockefeller. Took us off plant based drugs in the 1930 iirc and wreaked havoc on our health. But it did help protect the MDs source of money.
By any chance, do you have a book reference that discusses that change?
I’ve been thinking about it a little, and about the rather basic level of medicine that I received when I was a child. It wasn’t exactly “nature based herbal medicine” but it was clearly based on that sort of tradition. But today, it’s all fancy chemicals from enormous conglomerates and I suppose some would say it’s now “better” but I’m not sure that I agree it’s truly “better”. I’m trying to do a little research into how we got here.
Big mistake to be pursuing chemical modification of blood cholesterol on the basis of the fraudulent lipid hypothesis.
HUGE mistake, wrong direction.
Thanks for posting...
It’s the excuse to get something that blocks your active cancer from metastasizing.
I’d rather have the lowest daily dose of a statin than die in two years from the unchecked MACC1 gene.
Statins are the only thing known to block it.
One change in the American diet is the introduction of seed oils in the 20th century. The highest source of omega 6 fats are seed oils. The percentage of fat in people’s bodies that is omega 6 fats keeps increasing, so that change in diet is still having effects.
Many experiments found that omega 6 fats increase weight and cause cancer.
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Foods contain more vitamin a than we need.
Milk sellers threatened by the government add vitamin a to skim milk.
Yup. Yet another ‘treatment’. /s
...and failure to identify prevention.
I guarantee that most of those reading this will interpret that the taking of statins is equivalent to prophylaxis for not just CVD, but cancer, and merrily continue their lousy lifestyle.
Statins are poison.
Found this, tends to agree with prior FR research.
https://truth11.com/2020/11/23/the-rockefeller-drug-empire-since-1913/
Thanks!
Bigger problem, when rich arzholes have more money, power and influence than most countries how do you reign them in? Even if we can chop the roots won’t crony capitalism continue to do a hydra and just grow mo heads?
Wonder bread, floride in the water, vitamin D fortified whole milk, etc - a list much longer than any grocery list.
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